Special Issue "Novel Electrochemical Biosensors for Clinical Assays"
Deadline for manuscript submissions: closed (31 March 2021).
Interests: amperometric biosensors; protein/ biomaterial interactions; enhanced sensing devices; enzyme immobilization; electrosynthesis of thin polymeric films; HPLC and FIA detection
Biosensors, i.e., devices where biological molecules or bio(mimetic)structures are intimately coupled to a chemo/physical transducer for converting a biorecognition event into a measurable signal, have recently gained a wide (if not huge) academic and practical interest for the multitude of their applications in analysis, especially in the field of bioanalysis, medical diagnostics, and clinical assays. Indeed, thanks to their very simple use (permitting sometimes their application at home), the minimal sample pretreatment requirement, the higher selectivity, and sensitivity, biosensors are an essential tool in the detection and monitoring of a wide range of medical conditions from glycemia to Alzheimer’s disease as well as in the monitoring of drug responses. Soon, we expect that their importance and use in clinical diagnostics will expand rapidly so as to be of critical importance to public health in the coming years.
In this context, electrochemical biosensors definitely play an innovative and quite promising role, particularly due to their clear advantages over, e.g., the spectroscopic methods, since they can be used even when the clinical samples are turbid or coloured. More important, electrochemical biosensors and the relevant instrumentations are cheap, easy to use, and usable in field analysis with a minimum or no sample pretreatment. Of course, to be effective in clinical assays, the biorecognition event of the desired analyte needs to be developed and optimized so further efforts are required in choosing/designing the required biomolecule/structure and its efficient coupling to the transducer; not less important, the flow of the bio/chemical information starting from the biorecognition event to the chemo/physical detection needs to be studied and optimized as well. On the other hand, electrochemical detection is not without its drawbacks since it is barely selective, so novel and more effective electrochemical detection approaches need to be studied and developed to assure an interferent-free detection of analytes in clinical samples without sample pretreatment.
This Special Issue focuses on research and development in the field of biosensors as analytical tools for clinical assays and medical diagnostics. It is a pleasure for me to invite you to participate to this Special Issue by submitting both original research papers and review articles.
Prof. Dr. Antonio Guerrieri
Manuscript Submission Information
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- Electrochemical biosensors
- Immobilized bioreceptors
- Biorecognition kinetics
- Modified electrodes
- Polymeric film
- Molecular imprinted polymer
- Sample interference
- Clinical analysis
- Medical diagnostics