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Open AccessLetter

Assessment of Gold Bio-Functionalization for Wide-Interface Biosensing Platforms

Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, 70125 Bari, Italy
CSGI (Centre for Colloid and Surface Science), Department of Chemistry, 70125 Bari, Italy
The Faculty of Science and Engineering, Åbo Akademi University, FI-20500 Turku, Finland
Author to whom correspondence should be addressed.
Sensors 2020, 20(13), 3678;
Received: 28 May 2020 / Revised: 19 June 2020 / Accepted: 28 June 2020 / Published: 30 June 2020
(This article belongs to the Special Issue Novel Electrochemical Biosensors for Clinical Assays)
The continuous improvement of the technical potential of bioelectronic devices for biosensing applications will provide clinicians with a reliable tool for biomarker quantification down to the single molecule. Eventually, physicians will be able to identify the very moment at which the illness state begins, with a terrific impact on the quality of life along with a reduction of health care expenses. However, in clinical practice, to gather enough information to formulate a diagnosis, multiple biomarkers are normally quantified from the same biological sample simultaneously. Therefore, it is critically important to translate lab-based bioelectronic devices based on electrolyte gated thin-film transistor technology into a cost-effective portable multiplexing array prototype. In this perspective, the assessment of cost-effective manufacturability represents a crucial step, with specific regard to the optimization of the bio-functionalization protocol of the transistor gate module. Hence, we have assessed, using surface plasmon resonance technique, a sustainable and reliable cost-effective process to successfully bio-functionalize a gold surface, suitable as gate electrode for wide-field bioelectronic sensors. The bio-functionalization process herein investigated allows to reduce the biorecognition element concentration to one-tenth, drastically impacting the manufacturing costs while retaining high analytical performance. View Full-Text
Keywords: surface plasmon resonance; biosensors; bio-functionalization optimization; cost-effective biosensors; lab-on-a-chip surface plasmon resonance; biosensors; bio-functionalization optimization; cost-effective biosensors; lab-on-a-chip
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Sarcina, L.; Torsi, L.; Picca, R.A.; Manoli, K.; Macchia, E. Assessment of Gold Bio-Functionalization for Wide-Interface Biosensing Platforms. Sensors 2020, 20, 3678.

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