Post-COVID Rheumatic and Immune-Mediated Diseases

A special issue of Rheumato (ISSN 2674-0621).

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 4255

Special Issue Editors


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Guest Editor
Medicine and Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
Interests: COVID; rheumatic manifestations; post-infectious autoimmune diseases; systemic sclerosis; gout; CPPD
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Guest Editor
Medicine and Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli (IOR), Bologna, Italy
Interests: COVID; rheumatic manifestations; post-infectious autoimmune diseases; autoinflammatory diseases; connective tissue diseases

Special Issue Information

Dear Colleagues,

The potential role of viruses in the development of rheumatic diseases is well recognized, either as causative agents or as antigenic triggers for the development of autoimmunity. Inflammatory musculoskeletal manifestations following COVID-19 have been described since the earliest phases of the pandemic. Since symptoms of potential rheumatologic interest have been frequently reported in COVID-19 patients, the new virus outbreak represents a previously unseen differential diagnosis to be henceforth taken into consideration, and a “post-COVID-19 syndrome” with rheumatological manifestations is increasingly recognized as a potential complication of SARS-CoV-2 infection. Furthermore, inflammatory musculoskeletal symptoms may occasionally develop in close temporal association with COVID-19 vaccine administration. Previous studies assumed a possible association between the onset of autoimmune inflammatory diseases and vaccinations. Adjuvants may be responsible for inducing post-vaccination adverse events, in the so-called ‘ASIA’ syndrome, which represents a spectrum of presumably immune-mediated diseases secondary to the exposure to an adjuvant, associated with individual genetic predisposition.

This Special Issue aims to provide an overview of the spectrum of post-COVID-19 or post-COVID-19 vaccination rheumatic and immune-mediated diseases.

Dr. Jacopo Ciaffi
Dr. Francesco Ursini
Guest Editors

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Keywords

  • COVID-19
  • post-infection
  • vaccination
  • inflammatory
  • immune-mediated
  • rheumatic

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Published Papers (1 paper)

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37 pages, 1795 KiB  
Systematic Review
Non-Multisystem Inflammatory Syndrome in Children—Postacute Sequelae of Paediatric COVID-19: Autoimmune or Autoinflammatory? A Systematic Review of the Reported Cases
by Antoine Fakhry AbdelMassih, Maram Hamed Hanafy, Maryam ElAhmady, Sylvia Kozman, Nourine Diab, Reem Husseiny, Ashrakat Deyab, Aalaa Mady, Alia Yasser, Amira R. AbdelHalim, Aya Mohyeldin, Aya Sayed Serour, Ayat AbdelGadir, Eslam Abdelaziz, Farida ElGhamry, Hana Amr, Karim Milad, Lamya Fouda, Mawada Hesham, Mina Adly Riad, Mohamed Aoun, Rana AbdelTawab, Rana Sayed, Salma ElSenbawy, Sara ElAhmady Abdelkhalek, Nada Gamal and Yasmin Omaradd Show full author list remove Hide full author list
Rheumato 2023, 3(2), 132-168; https://doi.org/10.3390/rheumato3020011 - 30 May 2023
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Abstract
Three years after its emergence, coronavirus disease 2019 (COVID-19) continues to be a leading cause of worldwide morbidity and mortality. This systematic review comprises relevant case reports that discuss non-multisystem inflammatory syndrome in children (non-MIS-C) and postacute sequalae of COVID-19 (PASC) in the [...] Read more.
Three years after its emergence, coronavirus disease 2019 (COVID-19) continues to be a leading cause of worldwide morbidity and mortality. This systematic review comprises relevant case reports that discuss non-multisystem inflammatory syndrome in children (non-MIS-C) and postacute sequalae of COVID-19 (PASC) in the paediatric population, also known as long COVID syndrome. The study aims to highlight the prevalent time interval between COVID-19 and the development of non-MIS-C post-infectious sequalae (PIS). Databases were searched for studies that met our inclusion and exclusion criteria. The final screening revealed an equal sex distribution where the commonest age intervals were school-age and adolescence, with 38% of the patients being older than six years. Interestingly, hospital admission during the course of COVID-19 was not a predictor of the subsequent PASC; forty-nine patients (44.9%) were hospitalized while sixty patients (55.1%) were not hospitalized. Moreover, the most predominant time interval between COVID-19 and the developing PASC was within 14 days from the start of COVID-19 infection (61%). These findings suggest a crucial link between COVID-19 and immune PIS in the paediatric population, especially those older than six years. Accordingly, follow-up and management are encouraged in case of unusual symptoms and signs following COVID-19 infection, regardless of the COVID-19 infection severity. Full article
(This article belongs to the Special Issue Post-COVID Rheumatic and Immune-Mediated Diseases)
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