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Rheumato, Volume 5, Issue 4

2025 December - 4 articles

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Articles (4)

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Feature Paper
Review

3 Citations

3,132 Views

46 Pages

Emerging AI- and Biomarker-Driven Precision Medicine in Autoimmune Rheumatic Diseases: From Diagnostics to Therapeutic Decision-Making

Ola A. Al-Ewaidat and
Moawiah M. Naffaa

Rheumato2025, 5(4), 17;https://doi.org/10.3390/rheumato5040017

17 November 2025

Background/Objectives: Autoimmune rheumatic diseases (AIRDs) are complex, heterogeneous, and relapsing–remitting conditions in which early diagnosis, flare prediction, and individualized therapy remain major unmet needs. This review aims to syn...

Full Article

Case Report

539 Views

6 Pages

Rare Case of Hemoglobin Lepore Trait in a Bangladeshi Patient with Polyarthritis and Fever: Case Description and Brief Literature Review

Nira Ferdous,
Md. Nazrul Islam,
Abu Talha Mustakim and
Johannes J. Rasker

Rheumato2025, 5(4), 16;https://doi.org/10.3390/rheumato5040016

10 November 2025

Introduction: In hemoglobinopathies, the amount of globin synthesis in hemoglobin (Hb) or its structure is altered. Clinical features are related to the rate and kind of structural aberrations. The heterozygous form of the Lepore syndrome resembles m...

Full Article

Review

4,013 Views

16 Pages

CAR-T Cell Therapy in Autoimmune Diseases: Promise, Progress, and Pitfalls

Alessandro Conforti,
Carlos Cifuentes-González,
Alarico Ariani,
Alberto Lo Gullo and
Rupesh Agrawal

Rheumato2025, 5(4), 15;https://doi.org/10.3390/rheumato5040015

31 October 2025

Background: Chimeric Antigen Receptor T-cell (CAR-T) cell therapy has revolutionized cancer treatment and is now being explored as a novel approach to treat refractory autoimmune diseases by targeting autoreactive immune components, especially B cell...

Full Article

Article

928 Views

15 Pages

Using Social Media Listening to Characterize the Flare Lexicon in Patients with Sjögren’s Disease

Chiara Baldini,
Maurice Flurie,
Zachary Cline,
Colton Flowers,
Coralie Peter Bouillot,
Linda J. Stone,
Lauren Dougherty,
Christopher DeFelice and
Maria Picone

Rheumato2025, 5(4), 14;https://doi.org/10.3390/rheumato5040014

26 September 2025

Background/Objectives: Sjögren’s disease (SjD) flares are incompletely understood. The patient perspective is critical to closing this gap. This retrospective social media listening (SML) study characterized the flare lexicon within the on...

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