Biological and Pharmacological Activity of Natural Products

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Pharmaceutical Processes".

Deadline for manuscript submissions: closed (20 June 2026) | Viewed by 2991

Editors


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Guest Editor
Department of Biology, Faculty of Sciences Dhar Mehraz, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco
Interests: functional foods; bioactive molecules; synergistic interaction; inflammation; oxidative stress; management; cardio-metabolic diseases

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Guest Editor
Department of Chemical Engineering, Faculty of Science, University of Vigo, Ourense, Spain
Interests: green chemistry; food science; pharmacology; organic chemistry; biotechnology; waste management
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of pharmacy, Faculty of Medicine, Phamacy, and Dental Medicine, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco
Interests: natural products; metabolic disorders; oxidative stress

Special Issue Information

Dear Colleagues,

Background

Natural products have long been valued for their diverse biological and pharmacological properties, presenting significant therapeutic potential for various health conditions. Furthermore, many in vitro and in vivo studies provide evidence that natural product-derived bio-compounds and functional dietary phytochemicals possess antioxidant, antimicrobial, anti-inflammatory, anticancer, neuroprotective, cardio-protective, and immunomodulatory effects. Their capacity to modulate key molecular targets and signaling pathways has positioned them as promising candidates for drug discovery and the development of functional health products. Consequently, extracts from natural products and/or agri-food waste represent a valuable source of phytochemical molecules with potential pharmaceutical and nutraceutical applications.

Scope of the Special Issue

This Special Issue seeks high-quality original research articles and comprehensive reviews, investigating novel, unconventional, and original properties of plant-derived compounds, with a particular focus on their biological and pharmacological activities using in vitro, in vivo, and ex vivo assays, exploring possible involved signaling pathways and underscored mechanisms of action.

For this collection, we invite contributions that explore the following topics:​

  • Application of novel green technologies for the extraction and recovery of bioactive molecules with potential therapeutic effects;
  • Biological and pharmacological efficacies of characterized extracts or purified biomolecules (antioxidant, antimicrobial, anticancer, antihypertensive, antidiabetic, and other activities);
  • Synergistic effects of combined natural products/extracts or their association with conventional therapies​;
  •  Impact of natural products on gut microbiota composition and its relationship with overall health and well-being;
  • Development of novel formulations and delivery systems to enhance the bioavailability and therapeutic efficacy of natural compounds​;
  • Development of high-value formulations derived from natural products and/or agri-food by-products for pharmaceutical applications.

These topics collectively contribute to a deeper understanding of how functional products/by-products and their active components influence health outcomes, offering insights into potential therapeutic applications in the context of global health disorders.

Dr. Hassan Laaroussi
Dr. Pedro Ferreira-Santos
Dr. Driss Ousaaid
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • functional foods
  • green extraction
  • bioactive molecules
  • bioavailability
  • medicinal chemistry
  • combinatorial medicine
  • pharmacological activities
  • health disorders

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Published Papers (2 papers)

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Research

12 pages, 2544 KB  
Article
Attenuation of Chemotherapy-Associated Immune Suppression Markers by Socheongryong-Tang via ROS/MAPK/NF-κB-Associated Macrophage Activation
by Youngsic Jeon, Hyukjoon Kwon, Hyeonseok Ko, Gyuwon Huh, Solmin Yong, Taejung Kim, Young-Tae Park, Su Nam Kim, Jin-hyoung Jeong, Jae-hyun Jo, Ki Sung Kang and Young-Joo Kim
Processes 2026, 14(5), 742; https://doi.org/10.3390/pr14050742 - 25 Feb 2026
Viewed by 599
Abstract
Socheongryong-tang (SCRT), traditionally used in East Asia for managing chills and fever, has recently gained attention for its immunomodulatory potential. This study aimed to elucidate the biological activity and signaling features associated with SCRT-mediated modulation of innate immune readouts in murine macrophages and [...] Read more.
Socheongryong-tang (SCRT), traditionally used in East Asia for managing chills and fever, has recently gained attention for its immunomodulatory potential. This study aimed to elucidate the biological activity and signaling features associated with SCRT-mediated modulation of innate immune readouts in murine macrophages and to evaluate its effects on selected markers in a 5-fluorouracil (5-FU)-associated immune suppression model. Our findings reveal that SCRT significantly enhances phagocytic activity, production of nitric oxide and prostaglandin E2, and the mRNA expression of cytokines, including tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6. These immunomodulatory effects are associated with activation of the reactive oxygen species/mitogen-activated protein kinases/nuclear factor-κB signaling axis. In vivo, SCRT administration in a 5-FU–treated mouse model attenuated immune suppression-associated changes, showing partial restoration of selected serum cytokine markers and immune response indices. Taken together, these results suggest that SCRT aqueous extract may attenuate chemotherapy-associated immune dysfunction; however, further studies incorporating immune cell profiling, functional immune assessments, and pathway- and contamination-control approaches are warranted to establish causality and translational relevance. Full article
(This article belongs to the Special Issue Biological and Pharmacological Activity of Natural Products)
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26 pages, 2555 KB  
Article
Bactericidal and Antineoplastic Properties of Phyto-Formulated Nano Gold Composite Using Dwarf Copperleaf Plant
by Gayathri Vijayakumar, Abhiraami Kavirajan, Keerthi Neminla and Senthil Kumaran Rangarajulu
Processes 2026, 14(1), 105; https://doi.org/10.3390/pr14010105 - 28 Dec 2025
Cited by 1 | Viewed by 850
Abstract
Biogenic synthesis of gold nanoparticles using plant extracts has been widely explored for biomedical applications due to its eco-friendly and cost-effective nature. In this study, gold nanoparticles were phytoformulated using an ethanolic extract of dwarf copper leaf. Their physicochemical properties, antineoplastic activity against [...] Read more.
Biogenic synthesis of gold nanoparticles using plant extracts has been widely explored for biomedical applications due to its eco-friendly and cost-effective nature. In this study, gold nanoparticles were phytoformulated using an ethanolic extract of dwarf copper leaf. Their physicochemical properties, antineoplastic activity against MCF-7 breast cancer cells, and bactericidal efficacy against selected pathogenic microorganisms were systematically evaluated. The phyto-synthesized AuNPs show potential as an antineoplastic agent, significantly dropping the viability of MCF-7 breast cancer cells when administered at higher concentrations. Comprehensive characterization revealed that the phyto-formulated AuNPs were predominantly spherical with sizes ranging from 15–38 nm as observed by TEM, while XRD analysis confirmed their crystalline nature. Furthermore, FT-IR analysis determined the plant extract’s functional groups, which served as both reducing and stabilizing agents during synthesis. Additionally, the phyto-formulated AuNPs showed bactericidal efficacy against several microorganisms, including Bacillus cereus, Salmonella typhimurium, Staphylococcus epidermidis, and Serratia species. Particularly, the phyto-formulated AuNPs were effective against B. cereus and Serratia species. The present results showed that the phyto-formulated AuNPs could be used in biomedical contexts for bactericidal action and medication delivery. By using this cost-effective and eco-friendly nanobiotechnology method, AuNPs can enhance drug delivery and efficacy with lower toxicity effects associated with conventional chemotherapies. Full article
(This article belongs to the Special Issue Biological and Pharmacological Activity of Natural Products)
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