Special Issue "Polymer Materials for Drug Delivery and Tissue Engineering"

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 31 May 2022.

Special Issue Editors

Dr. Ariana Hudita
E-Mail Website
Guest Editor
Department of Biochemistry and Molecular biology, Faculty of Biology, University of Bucharest, Bucharest 061071, Romania
Interests: nanoscaled drug delivery nanoscaled drug delivery systems; tumor-on-chip systems; colorectal cancer research; regenerative medicine; tissue engineering
Special Issues and Collections in MDPI journals
Dr. Bianca Gǎlǎţeanu
E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, Bucharest, Romania
Interests: colon cancer research; nanoscaled drug delivery systems; tumor-on-chip; liquid biopsy; pharmacogenomics; personalized medicine
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The recent years have witnessed an impressive development of modern therapies because of the appearance of numerous novel drug-delivery systems and biomaterials synthetized for tissue engineering purposes. The use of polymer-based biomaterials (natural, synthetic, or blends) has played a pivotal role in the tremendous advances reported in the biomedical field because of their tailorable designs, versatility, attractive physiochemical properties, and excellent biocompatibility. On the one hand, polymer-based materials are widely used in tissue engineering for the design and fabrication of biomimetic scaffolds that resemble the complex architecture of the defective tissues, which are easily engineered to exert distinct biological functions. On the other hand, polymers have been used for drug and gene delivery systems fabrication because of their ability to carry both hydrophilic and hydrophobic drugs or other molecules, with a controlled release of controllable doses, that can be biofunctionalized to ensure the efficient delivery of pharmacological cargo to the desired site. Moreover, functional polymer-based biomaterials with dual function, scaffolds, and delivery vehicles for therapeutic agents and biological cues are currently an attractive modern approach in regenerative medicine. Independent of the targeted application, smart polymers currently represent a popular choice in the biomedical field, as these stimuli-responsive materials can adapt to the biological environment, thus providing a real opportunity for designing personalized biomedical products.

This Special Issue titled “Polymer Materials for Drug Delivery and Tissue Engineering” will focus on the recent development of polymeric materials intended for tissue engineering or drug-delivery applications. In this regard, we warmly invite members of the academic and scientific communities to contribute original papers, short communications, or reviews on the development, characterization, and possible biological applications of polymer-based biomaterials, with applications in drug delivery and tissue engineering. The purpose of this Special Issue is to gather cutting-edge research and new insights into polymer-based biomaterial progress in terms of novel and innovative methods of synthesis and functionalization, as well as modern approaches for in vitro and in vivo biological effect investigations.

Dr. Ariana Hudita
Dr. Bianca Gǎlǎţeanu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Bioinspired implantable materials
  • Nanoshuttles
  • Polymeric drug delivery systems
  • Tissue engineering
  • Regenerative medicine
  • Non-viral vectors
  • Modern biomedicine

Published Papers (3 papers)

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Research

Article
Ethyl Cellulose and Hydroxypropyl Methyl Cellulose Blended Methotrexate-Loaded Transdermal Patches: In Vitro and Ex Vivo
Polymers 2021, 13(20), 3455; https://doi.org/10.3390/polym13203455 - 09 Oct 2021
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Abstract
Transdermal drug delivery systems (TDDSs) have become innovative, fascinating drug delivery methods intended for skin application to achieve systemic effects. TDDSs overcome the drawbacks associated with oral and parenteral routes of drug administration. The current investigation aimed to design, evaluate and optimize methotrexate [...] Read more.
Transdermal drug delivery systems (TDDSs) have become innovative, fascinating drug delivery methods intended for skin application to achieve systemic effects. TDDSs overcome the drawbacks associated with oral and parenteral routes of drug administration. The current investigation aimed to design, evaluate and optimize methotrexate (MTX)-loaded transdermal-type patches having ethyl cellulose (EC) and hydroxypropyl methyl cellulose (HPMC) at different concentrations for the local management of psoriasis. In vitro release and ex vivo permeation studies were carried out for the formulated patches. Various formulations (F1–F9) were developed using different concentrations of HPMC and EC. The F1 formulation having a 1:1 polymer concentration ratio served as the control formulation. ATR–FTIR analysis was performed to study drug–polymer interactions, and it was found that the drug and polymers were compatible with each other. The formulated patches were further investigated for their physicochemical parameters, in vitro release and ex vivo diffusion characteristics. Different parameters, such as surface pH, physical appearance, thickness, weight uniformity, percent moisture absorption, percent moisture loss, folding endurance, skin irritation, stability and drug content uniformity, were studied. From the hydrophilic mixture, it was observed that viscosity has a direct influence on drug release. Among all formulated patches, the F5 formulation exhibited 82.71% drug release in a sustained-release fashion and followed an anomalous non-Fickian diffusion. The permeation data of the F5 formulation exhibited about a 36.55% cumulative amount of percent drug permeated. The skin showed high retention for the F5 formulation (15.1%). The stability study indicated that all prepared formulations had very good stability for a period of 180 days. Therefore, it was concluded from the present study that methotrexate-loaded transdermal patches with EC and HPMC as polymers at different concentrations suit TDDSs ideally and improve patient compliance for the local management of psoriasis. Full article
(This article belongs to the Special Issue Polymer Materials for Drug Delivery and Tissue Engineering)
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Article
Surface Characterization and Physiochemical Evaluation of P(3HB-co-4HB)-Collagen Peptide Scaffolds with Silver Sulfadiazine as Antimicrobial Agent for Potential Infection-Resistance Biomaterial
Polymers 2021, 13(15), 2454; https://doi.org/10.3390/polym13152454 - 26 Jul 2021
Viewed by 442
Abstract
Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] is a bacterial derived biopolymer widely known for its unique physical and mechanical properties to be used in biomedical application. In this study, antimicrobial agent silver sulfadiazine (SSD) coat/collagen peptide coat-P(3HB-co-4HB) (SCCC) and SSD blend/collagen [...] Read more.
Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] is a bacterial derived biopolymer widely known for its unique physical and mechanical properties to be used in biomedical application. In this study, antimicrobial agent silver sulfadiazine (SSD) coat/collagen peptide coat-P(3HB-co-4HB) (SCCC) and SSD blend/collagen peptide coat-P(3HB-co-4HB) scaffolds (SBCC) were fabricated using a green salt leaching technique combined with freeze-drying. This was then followed by the incorporation of collagen peptides at various concentrations (2.5–12.5 wt.%) to P(3HB-co-4HB) using collagen-coating. As a result, two types of P(3HB-co-4HB) scaffolds were fabricated, including SCCC and SBCC scaffolds. The increasing concentrations of collagen peptides from 2.5 wt.% to 12.5 wt.% exhibited a decline in their porosity. The wettability and hydrophilicity increased as the concentration of collagen peptides in the scaffolds increased. In terms of the cytotoxic results, MTS assay demonstrated the L929 fibroblast scaffolds adhered well to the fabricated scaffolds. The 10 wt.% collagen peptides coated SCCC and SBCC scaffolds displayed highest cell proliferation rate. The antimicrobial analysis of the fabricated scaffolds exhibited 100% inhibition towards various pathogenic microorganisms. However, the SCCC scaffold exhibited 100% inhibition between 12 and 24 h, but the SBCC scaffolds with SSD impregnated in the scaffold had controlled release of the antimicrobial agent. Thus, this study will elucidate the surface interface-cell interactions of the SSD-P(3HB-co-4HB)-collagen peptide scaffolds and controlled release of SSD, antimicrobial agent. Full article
(This article belongs to the Special Issue Polymer Materials for Drug Delivery and Tissue Engineering)
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Article
In Vitro Interaction of Doxorubicin-Loaded Silk Sericin Nanocarriers with MCF-7 Breast Cancer Cells Leads to DNA Damage
Polymers 2021, 13(13), 2047; https://doi.org/10.3390/polym13132047 - 22 Jun 2021
Viewed by 767
Abstract
In this paper, Bombyx mori silk sericin nanocarriers with a very low size range were obtained by nanoprecipitation. Sericin nanoparticles were loaded with doxorubicin, and they were considered a promising tool for breast cancer therapy. The chemistry, structure, morphology, and size distribution of [...] Read more.
In this paper, Bombyx mori silk sericin nanocarriers with a very low size range were obtained by nanoprecipitation. Sericin nanoparticles were loaded with doxorubicin, and they were considered a promising tool for breast cancer therapy. The chemistry, structure, morphology, and size distribution of nanocarriers were investigated by Fourier transformed infrared spectroscopy (FTIR–ATR), scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and dynamic light scattering (DLS). Morphological investigation and DLS showed the formation of sericin nanoparticles in the 25–40 nm range. FTIR chemical characterization showed specific interactions of protein–doxorubicin–enzymes with a high influence on the drug delivery process and release behavior. The biological investigation via breast cancer cell line revealed a high activity of nanocarriers in cancer cells by inducing significant DNA damage. Full article
(This article belongs to the Special Issue Polymer Materials for Drug Delivery and Tissue Engineering)
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