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Polymers toward Mechanobiology

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 4266

Special Issue Editor


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Guest Editor
Department of Life Sciences, University of Trieste, 34127 Trieste, Italy
Interests: polysaccharides; chitosans; fabrication of innovative hydrogels; hydrogel-to-cell interplay; mechanobiology; regenerative medicine

Special Issue Information

Dear Colleagues,

Mounting evidence has recognized that mechanical cues linked to extracellular milieus represent potent modulators in directing cell behavior, tissue development or eliciting onset of pathologies. Recapitulating spatial and temporal living tissue architecture is essential to comprehend, and eventually predict, cell fate decisions. Enormous efforts are currently being undertaken to assemble 2D and 3D networks exhibiting desired mechanics as a model to study cell response. Hence, bottom–up approaches encompassing the selection (and eventual chemical modification) of innovative polymers up to the assembly thereof are sought to unveil unprecedented materials.

The aim of this Special Issue of Polymers is to bring together researchers at the edge of polymer chemistry, materials assembly, and related applications in the mechanobiology field. A cadre of themes of large interest are welcomed, including—but not limited to—polymer chemical modifications to modulate resulting material mechanics and/or direct cell fate decisions, stimuli-responsive polymers, substrate-to-cell interplay (mechanotransmission/transduction), and recent developments in smart polymers in relation to mechanobiology, to mention just a few examples.

Dr. Pasquale Sacco
Guest Editor

Keywords

  • polymer chemistry
  • polymer application
  • macromolecular assembly
  • fabrication of innovative biomaterials
  • mechanical investigation
  • biomaterial-to-cell interplay
  • mechanobiology

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Published Papers (1 paper)

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15 pages, 12840 KiB  
Article
Mechanical Stress Inhibits Early Stages of Endogenous Cell Migration: A Pilot Study in an Ex Vivo Osteochondral Model
by Maria L. Vainieri, Mauro Alini, Avner Yayon, Gerjo J. V. M. van Osch and Sibylle Grad
Polymers 2020, 12(8), 1754; https://doi.org/10.3390/polym12081754 - 6 Aug 2020
Cited by 6 | Viewed by 3547
Abstract
Cell migration has a central role in osteochondral defect repair initiation and biomaterial-mediated regeneration. New advancements to reestablish tissue function include biomaterials and factors promoting cell recruitment, differentiation and tissue integration, but little is known about responses to mechanical stimuli. In the present [...] Read more.
Cell migration has a central role in osteochondral defect repair initiation and biomaterial-mediated regeneration. New advancements to reestablish tissue function include biomaterials and factors promoting cell recruitment, differentiation and tissue integration, but little is known about responses to mechanical stimuli. In the present pilot study, we tested the influence of extrinsic forces in combination with biomaterials releasing chemoattractant signals on cell migration. We used an ex vivo mechanically stimulated osteochondral defect explant filled with fibrin/hyaluronan hydrogel, in presence or absence of platelet-derived growth factor-BB or stromal cell-derived factor 1, to assess endogenous cell recruitment into the wound site. Periodic mechanical stress at early time point negatively influenced cell infiltration compared to unloaded samples, and the implementation of chemokines to increase cell migration was not efficient to overcome this negative effect. The gene expression at 15 days of culture indicated a marked downregulation of matrix metalloproteinase (MMP)13 and MMP3, a decrease of β1 integrin and increased mRNA levels of actin in osteochondral samples exposed to complex load. This work using an ex vivo osteochondral mechanically stimulated advanced platform demonstrated that recurrent mechanical stress at early time points impeded cell migration into the hydrogel, providing a unique opportunity to improve our understanding on management of joint injury. Full article
(This article belongs to the Special Issue Polymers toward Mechanobiology)
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