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Polymers
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Nanomaterials Template for Organic or Composite Polymers in Biomedical Application...
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Nanomaterials Template for Organic or Composite Polymers in Biomedical Application III

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (25 April 2024) | Viewed by 2976

Special Issue Editor

Prof. Dr. Wen-Cheng Chen

E-Mail Website
Guest Editor
Department of Fiber and Composite Materials, Feng Chia University, Taichung 407, Taiwan
Interests: biomaterials; material analysis; polymer chemistry; medical engineering; functional fiber composites; nanomaterials; tissue engineering; hydrogels
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Very recently, nanomaterials have attracted a lot of attention in multidisciplinary academic fields, including engineering, chemistry, solid-state physics, biotechnology, and biomedicine. The most important features of these nanomaterials are their polarity, modification capability, and diverse properties. Therefore, the application of nanomaterials in the clinical field revokes many revolutionary solutions in tissue reconstruction when the tissue is defective. In addition, nanomaterials are also useful in developing multi-functionalized drugs, antibacterial products, etc. The nanoparticle platforms that have been extensively explored for biomedical applications are predominantly either purely inorganic or organic materials. Hybrid nanoparticles or organic composites with inorganics can not only retain the beneficial features of both inorganic and organic nanomaterials, but they can also possess unique advantages over the other two types. The changeable material design can derive a variety of clinical treatment strategies.

This Special Issue focuses on the use of organic/inorganic or hybrid nanomaterials for biomedical applications. We invite full papers, communications, and reviews. We would like to invite you to contribute to this Special Issue. Research topics of interest cover one or several of the topics included in (or related to) the keywords below.

Prof. Dr. Wen-Cheng Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • composites
  • nanomaterials
  • micelles
  • hydrogels
  • biodegradable
  • apatite
  • drug delivery
  • slow release
  • scaffold
  • tissue regeneration
  • biocompatibility
  • delivery
  • antibacterial
  • therapy
  • nanoparticle manufacture and processing

Related Special Issues

Published Papers (3 papers)

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Research

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23 pages, 13698 KiB  
Article
Investigation of the Effectiveness of Silicon Nitride as a Reinforcement Agent for Polyethylene Terephthalate Glycol in Material Extrusion 3D Printing
by Nikolaos Michailidis, Markos Petousis, Vassilis Saltas, Vassilis Papadakis, Mariza Spiridaki, Nikolaos Mountakis, Apostolos Argyros, John Valsamos, Nektarios K. Nasikas and Nectarios Vidakis
Polymers 2024, 16(8), 1043; https://doi.org/10.3390/polym16081043 - 10 Apr 2024
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Abstract
Polyethylene terephthalate glycol (PETG) and silicon nitride (Si3N4) were combined to create five composite materials with Si3N4 loadings ranging from 2.0 wt.% to 10.0 wt.%. The goal was to improve the mechanical properties of PETG in [...] Read more.
Polyethylene terephthalate glycol (PETG) and silicon nitride (Si3N4) were combined to create five composite materials with Si3N4 loadings ranging from 2.0 wt.% to 10.0 wt.%. The goal was to improve the mechanical properties of PETG in material extrusion (MEX) additive manufacturing (AM) and assess the effectiveness of Si3N4 as a reinforcing agent for this particular polymer. The process began with the production of filaments, which were subsequently fed into a 3D printer to create various specimens. The specimens were manufactured according to international standards to ensure their suitability for various tests. The thermal, rheological, mechanical, electrical, and morphological properties of the prepared samples were evaluated. The mechanical performance investigations performed included tensile, flexural, Charpy impact, and microhardness tests. Scanning electron microscopy and energy-dispersive X-ray spectroscopy mapping were performed to investigate the structures and morphologies of the samples, respectively. Among all the composites tested, the PETG/6.0 wt.% Si3N4 showed the greatest improvement in mechanical properties (with a 24.5% increase in tensile strength compared to unfilled PETG polymer), indicating its potential for use in MEX 3D printing when enhanced mechanical performance is required from the PETG polymer. Full article
(This article belongs to the Special Issue Nanomaterials Template for Organic or Composite Polymers in Biomedical Application III)
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18 pages, 77289 KiB  
Article
Hybrid-Aligned Fibers of Electrospun Gelatin with Antibiotic and Polycaprolactone Composite Membranes as an In Vitro Drug Delivery System to Assess the Potential Repair Capacity of Damaged Cornea
by Yi-Hsin Shao, Ssu-Meng Huang, Shih-Ming Liu, Jian-Chih Chen and Wen-Cheng Chen
Polymers 2024, 16(4), 448; https://doi.org/10.3390/polym16040448 - 06 Feb 2024
Viewed by 774
Abstract
The cornea lacks the ability to repair itself and must rely on transplantation to repair damaged tissue. Therefore, creating alternative therapies using dressing membranes based on tissue engineering concepts to repair corneal damage before failure has become a major research goal. Themost outstanding [...] Read more.
The cornea lacks the ability to repair itself and must rely on transplantation to repair damaged tissue. Therefore, creating alternative therapies using dressing membranes based on tissue engineering concepts to repair corneal damage before failure has become a major research goal. Themost outstanding features that are important in reconstructing a damaged cornea are the mechanical strength and transparency of the membrane, which are the most important standard considerations. In addition, preventing infection is an important issue, especially in corneal endothelial healing processes. The purpose of this study was to produce aligned fibers via electrospinning technology using gelatin (Gel) composite polycaprolactone (PCL) as an optimal transport and antibiotic release membrane. The aim of the composite membrane is to achieve good tenacity, transparency, antibacterial properties, and in vitro biocompatibility. Results showed that the Gel and PCL composite membranes with the same electrospinning flow rate had the best transparency. The Gel impregnated with gentamicin antibiotic in composite membranes subsequently exhibited transparency and enhanced mechanical properties provided by PCL and could sustainably release the antibiotic for 48 h, achieving good antibacterial effects without causing cytotoxicity. This newly developed membrane has the advantage of preventing epidermal tissue infection during clinical operations and is expected to be used in the reconstruction of damaged cornea in the future. Full article
(This article belongs to the Special Issue Nanomaterials Template for Organic or Composite Polymers in Biomedical Application III)
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Review

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23 pages, 4739 KiB  
Review
Poly(methyl methacrylate) in Orthopedics: Strategies, Challenges, and Prospects in Bone Tissue Engineering
by Susaritha Ramanathan, Yu-Chien Lin, Senthilkumar Thirumurugan, Chih-Chien Hu, Yeh-Fang Duann and Ren-Jei Chung
Polymers 2024, 16(3), 367; https://doi.org/10.3390/polym16030367 - 29 Jan 2024
Viewed by 1290
Abstract
Poly(methyl methacrylate) (PMMA) is widely used in orthopedic applications, including bone cement in total joint replacement surgery, bone fillers, and bone substitutes due to its affordability, biocompatibility, and processability. However, the bone regeneration efficiency of PMMA is limited because of its lack of [...] Read more.
Poly(methyl methacrylate) (PMMA) is widely used in orthopedic applications, including bone cement in total joint replacement surgery, bone fillers, and bone substitutes due to its affordability, biocompatibility, and processability. However, the bone regeneration efficiency of PMMA is limited because of its lack of bioactivity, poor osseointegration, and non-degradability. The use of bone cement also has disadvantages such as methyl methacrylate (MMA) release and high exothermic temperature during the polymerization of PMMA, which can cause thermal necrosis. To address these problems, various strategies have been adopted, such as surface modification techniques and the incorporation of various bioactive agents and biopolymers into PMMA. In this review, the physicochemical properties and synthesis methods of PMMA are discussed, with a special focus on the utilization of various PMMA composites in bone tissue engineering. Additionally, the challenges involved in incorporating PMMA into regenerative medicine are discussed with suitable research findings with the intention of providing insightful advice to support its successful clinical applications. Full article
(This article belongs to the Special Issue Nanomaterials Template for Organic or Composite Polymers in Biomedical Application III)
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