Plants and Natural Products: Phytochemistry, Pharmacological, Nutritional, and Cosmetic Applications

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 552

Editors


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Guest Editor
1. Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
2. Institute of Chemistry and Drug Metabolism of (IQUIMEFA), University of Buenos Aires–National Scientific and Technical Research Council, Buenos Aires, Argentina
Interests: neglected diseases; antimicrobial activity; antitumor activity; natural compounds; plant extracts; terpenoids; flavonoids; Asteraceae
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
2. Institute of Chemistry and Drug Metabolism of (IQUIMEFA), University of Buenos Aires–National Scientific and Technical Research Council, Buenos Aires, Argentina
Interests: neglected diseases; antimicrobial activity; antitumor activity; natural compounds; plant extracts; terpenoids; flavonoids; Asteraceae
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
AsterBioChem Research Team, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), Av. Professor Doutor Zeferino Vaz s/n, Ribeirão Preto 14040-903, SP, Brazil
Interests: plant metabolomics; chemoinformatics tools; plant chemistry

Special Issue Information

Dear Colleagues,

This Special Issue aims to highlight the multidisciplinary relevance of plants and plant-derived compounds, as well as their growing impacts on health, nutrition, and industry. Plants remain an invaluable source of molecules, having diverse chemical structures and biological properties. Their phytochemical diversity continues to inspire the development of new therapeutic agents, nutraceuticals, and cosmetic formulations. This Special Issue welcomes original research and reviews focusing on the study of plants and secondary metabolites with pharmacological potential, as well as functional foods and dietary supplements based on botanical ingredients and the use of plant extracts or purified compounds in cosmetic and dermatological applications. Additionally, contributions exploring biotechnological aspects and innovative analytical or computational approaches for the identification of natural bioactive compounds are encouraged. By integrating phytochemistry, pharmacology, nutrition, and cosmetic science, this Special Issue aims to provide a comprehensive overview of recent advances in plant-based natural products research.

Studies involving complex mixtures or extracts must be chemically characterized using appropriate methods.

Dr. Valeria P. Sülsen
Guest Editor

Dr. Laura C. Laurella
Prof. Dr. Fernando Batista Da Costa
Co-Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • medicinal plants
  • edible plants
  • natural products
  • bioactive compounds
  • pharmacological activity
  • nutraceuticals
  • cosmetics

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Published Papers (1 paper)

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Research

17 pages, 2118 KB  
Article
Isothiocyanate-Rich Essential Oil of Morisonia flexuosa L. Exhibits Anxiolytic-like Effects That May Involve Serotonergic Pathways in Zebrafish
by Fázia Fernandes Galvão Rodrigues, Natalia Kelly Gomes de Carvalho, Geane Gabriele de Oliveira Souza, Hélcio Silva dos Santos, Irwin Rose Alencar de Menezes, Amanda Maria Barros Alves, Jane Eire Silva Alencar de Menezes, Fabiola Fernandes Galvão Rodrigues and José Galberto Martins da Costa
Plants 2026, 15(12), 1812; https://doi.org/10.3390/plants15121812 - 12 Jun 2026
Viewed by 186
Abstract
Anxiety disorders are characterized by dysregulation of monoaminergic signaling and remain a significant therapeutic challenge due to limitations associated with current pharmacological treatments. In this context, the essential oil of Morisonia flexuosa (Capparaceae) seeds was chemically characterized and evaluated for anxiolytic-like activity in [...] Read more.
Anxiety disorders are characterized by dysregulation of monoaminergic signaling and remain a significant therapeutic challenge due to limitations associated with current pharmacological treatments. In this context, the essential oil of Morisonia flexuosa (Capparaceae) seeds was chemically characterized and evaluated for anxiolytic-like activity in adult zebrafish. Chemical profiling by GC–MS and GC–FID revealed a predominance of isothiocyanates, particularly butyl isothiocyanate (42.60%) and isobutyl isothiocyanate (42.28%). Acute toxicity assessment demonstrated no lethality at the tested doses. Behavioral analyses showed a significant increase in light preference in the light/dark paradigm, with moderate locomotor reduction insufficient to account for the behavioral shift solely by sedation. Pharmacological antagonism assays indicated that the anxiolytic-like effect was predominantly mediated by 5-HT1 and 5-HT2A/2C receptors. Chemometric analyses (PCA, HCA, and heatmap) revealed statistical association between compound abundance and behavioral endpoints, supporting the contribution of major isothiocyanates within the tested model. Notably, the strongest behavioral response was observed at the lowest concentration, suggesting an ideal effective concentration range. Collectively, these findings provide the first evidence that an isothiocyanate-rich essential oil from M. flexuosa exerts serotonergic-involved anxiolytic-like effects in zebrafish and supports further mechanistic investigation of its neuropharmacological potential. Full article
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