Bioactive Phytochemicals for Blood Glucose Regulation
A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 1797
Special Issue Editors
Interests: bioactive metabolites discovery; phytochemicals of secondary metabolites; structure elucidation; ethnopharmacology and pharmacology of natural products; molecular modeling and computational drug discovery; plant-derived therapeutics for diabetes and metabolic disorders
Interests: bioactive metabolites discovery; glycolipids from Convolvulaceae; structure elucidation; enzyme–ligand interactions and affinity-based assays; molecular modeling and computational drug design; diabetes and cancer
Interests: protein structure elucidation and function; marine and terrestrial toxins; protein structures and conformational changes in solution; hypoglycemic, antimicrobial, anticancer, antifungal, and neurotoxic compounds; drug discovery and industrial biotechnology
Special Issue Information
Dear Colleagues,
The rising global incidence of diabetes and related metabolic disorders underscores the urgent need for innovative therapeutic strategies to regulate blood glucose levels. Plants are a rich source of structurally diverse bioactive phytochemicals that have historically provided leads for modern drug development. Compounds such as alkaloids, flavonoids, terpenoids, and saponins have demonstrated significant hypoglycemic activity through diverse mechanisms, including modulation of insulin secretion, enhancement of insulin sensitivity, inhibition of carbohydrate-digesting enzymes, and regulation of glucose transporters and signaling pathways.
This Special Issue, “Bioactive Phytochemicals for Blood Glucose Regulation”, focuses on the discovery and development of plant-derived compounds with potential as in the treatment of diabetes. We invite original research and comprehensive reviews addressing the isolation, structural characterization, and mechanistic studies of novel phytochemicals, as well as their preclinical evaluation and optimization for therapeutic use. Topics of interest include bioassay-guided fractionation, structure–activity relationship (SAR) studies, molecular docking and modeling approaches, and advances in translating traditional medicinal knowledge into modern drug discovery pipelines.
By compiling cutting-edge research, this Special Issue aims to advance our understanding of natural products as sources of new drugs and to foster the development of innovative, plant-based strategies for the prevention and treatment of hyperglycemia and diabetes.
Dr. Sonia Escandón-Rivera
Dr. Daniel Rosas-Ramírez
Dr. Roberto Arreguín Espinosa de los Monteros
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- diabetes
- medicinal plants
- natural product chemistry
- phytochemicals
- traditional medicine
- ethnopharmacology
- natural product drug discovery
- compound isolation
- structure elucidation
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