Antioxidant and Anti-Inflammatory Activities of Plant Extracts and Phytochemicals—2nd Edition

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 951

Special Issue Editor

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to a Special Issue of the journal Plants focused on “Antioxidant and Anti-Inflammatory Activities of Plant Extracts and Phytochemicals.” Oxidation and inflammation are critical processes for normal cellular function and immune responses. Moreover, oxidative stress can trigger inflammation, and vice versa, creating a positive feedback loop. Consequently, an imbalance or dysregulation of these processes can contribute to the development and progression of various chronic diseases, including allergies, diabetes, cardiovascular disease, neurodegenerative diseases, and cancer. Therefore, understanding the interconnected nature of oxidation and inflammation is essential for the development of effective strategies for disease prevention and treatment. Targeting both processes represents a promising therapeutic approach for managing these pathological conditions.

Plants serve as a rich source of complex and highly structurally diverse chemical compounds. These compounds often serve as the starting point for drug discovery and development, having provided us with a plethora of clinically useful drugs, including paclitaxel, artemisinin, galantamine, and morphine. Notably, acetylsalicylic acid (aspirin), a nonsteroidal anti-inflammatory drug derived from salicylic acid found in willow and other salicylate-rich plants, has been employed to treat fever and pain for thousands of years. However, many natural compounds beneficial for human health remain undiscovered, particularly with regard to addressing oxidative stress and inflammation-associated diseases. In this context, this Special Issue aims to provide a comprehensive platform for researchers, scientists, and practitioners to share their latest research findings and insights related to the crucial role that plant extracts and phytochemicals play in combating oxidative stress and inflammation. We welcome submissions of original research articles, reviews, and short communications that explore plant extracts and phytochemicals, their antioxidant and/or anti-inflammatory activities, and their pharmacological potential in addressing oxidative stress- and inflammation-associated diseases. 

Prof. Dr. Seok-Geun Lee
Guest Editor

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Keywords

  • plants
  • phytochemicals
  • drug discovery
  • bioactive compounds
  • biochemometrics
  • metabolomics
  • molecular network analysis
  • oxidative stress
  • inflammation
  • oxidative stress

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Published Papers (1 paper)

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Research

23 pages, 939 KB  
Article
Polyphenolic Profile, Antioxidant, Antibacterial and Antidiabetic Activities of Acorns from Three Tunisian Quercus L. Species
by Abir Haddada, Aicha Laouani, Mohamed Iheb Ben Tekfa, Wissal Saadellaoui, Yassine M’rabet, Mariem Zakraoui, Christian Zidorn, Riccardo Trentin, Thomas Stegemann, Karim Hosni, Naouel Klibi, Hédia Hannachi, Igor Pasković, Marija Polić Pasković, Tomislav Kos, Dalibor Broznić, Maria João Rodrigues and Sondes Stambouli-Essassi
Plants 2026, 15(5), 762; https://doi.org/10.3390/plants15050762 - 1 Mar 2026
Cited by 2 | Viewed by 702
Abstract
This study aims to evaluate the interspecific variation in polyphenolic profiles and biological activities of acorn flours from three native Tunisian Quercus L. species (Q. ilex L., Q. suber L., and Q. canariensis Willd.). Q. canariensis extracts are the richest in total [...] Read more.
This study aims to evaluate the interspecific variation in polyphenolic profiles and biological activities of acorn flours from three native Tunisian Quercus L. species (Q. ilex L., Q. suber L., and Q. canariensis Willd.). Q. canariensis extracts are the richest in total phenolic, flavonoid and hydrolysable tannin contents. Six phenolic compounds were identified by HPLC-DAD analysis. Chlorogenic acid was the dominant compound in Q. canariensis and Q. ilex acorns. Whereas in Q. suber, caffeic acid was the main component and, along with trans-ferulic acid, was exclusive to this species. Hyperoside was notably identified in Q. canariensis. The UHPLC-DAD-MS analysis of hydrolysable tannins revealed twelve compounds. Acorns of Q. canariensis and Q. suber were dominated by ellagitannins, whereas Q. ilex contained mainly gallotannins. To our knowledge, these compounds are identified for the first time in Tunisian acorns. Q. canariensis exhibited the strongest antioxidant potential with DPPH, ABTS and FRAP assays, as well as the highest antibiofilm and anti-α-amylase activities. All extracts inhibited ATCC pathogenic bacterial strains while largely sparing the beneficial probiotic Limosilactobacillus fermentum. This result indicates a selective antibacterial effect not previously reported for Quercus acorns. Q. canariensis may represent a potential source of functional food ingredient, nutraceuticals, and pharmaceuticals, which remains to be confirmed through in vivo investigations. Full article
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