Medicinal Plants and Their Marker Compounds—Second Edition

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 20 June 2024 | Viewed by 2417

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Research Institute for Medicines (iMed.ULisboa), Department of Pharmacy, Pharmacology and Health Technologies, Faculty of Pharmacy. Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003 Lisbon, Portugal.
Interests: pharmacognosy; medicinal plants; herbal medicines quality, efficacy, and safety; ethnopharmacology; ethnopharmacy; rational phytotherapy; natural products
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Special Issue Information

Dear Colleagues,

In our first volume dealing with the role of medicinal plants and their marker compounds in clinical practice, we pointed out that herbal medicines and herbal medicines continue to be an integral part of the various healthcare systems. Scientific knowledge on the quality, safety and effectiveness of these herbal medicines and traditional herbal preparations is fundamental and should be deepened to enable more rational use of these medicines. Articles (original research papers, perspectives, reviews, modeling approaches and methods) focusing on quality control, pharmacological, clinical pharmacokinetics, toxicological and pharmacovigilance studies of medicinal plants, herbal preparations, and their key marker compounds as multitarget therapeutical agents are welcome for this Special Issue.

Dr. Olga Maria Duarte Silva
Guest Editor

Manuscript Submission Information

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Keywords

  • mode of action
  • herbal medicines
  • multitarget natural products
  • safety
  • biological activity

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Published Papers (2 papers)

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18 pages, 1375 KiB  
Article
An Integrated Approach to the Anti-Inflammatory, Antioxidant, and Genotoxic Potential of Portuguese Traditional Preparations from the Bark of Anacardium occidentale L.
by Sofia Encarnação, Katelene Lima, Quintino Malú, Gonçalo I. Caldeira, Maria Paula Duarte, João Rocha, Beatriz Silva Lima and Olga Silva
Plants 2024, 13(3), 420; https://doi.org/10.3390/plants13030420 - 31 Jan 2024
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Abstract
Anacardium occidentale L. stem bark Traditional Herbal Preparations (AoBTHPs) are widely used in traditional medicine to treat inflammatory conditions, such as diabetes. The present study aims to evaluate the anti-inflammatory, antioxidant, and genotoxic potential of red and white Portuguese AoBTHPs. Using a carrageenan-induced [...] Read more.
Anacardium occidentale L. stem bark Traditional Herbal Preparations (AoBTHPs) are widely used in traditional medicine to treat inflammatory conditions, such as diabetes. The present study aims to evaluate the anti-inflammatory, antioxidant, and genotoxic potential of red and white Portuguese AoBTHPs. Using a carrageenan-induced rat paw edema model, a significant anti-edema effect was observed for all tested doses of white AoBTHP (40.2, 71.5, and 127.0 mg/kg) and the two highest doses of red AoB THP (71.5 and 127.0 mg/kg). The anti-edema effect of red AoBTHP’s highest dose was much more effective than indomethacin 10 mg/kg, Trolox 30 mg/kg, and Tempol 30 mg/kg. In DPPH, FRAP, and TAC using the phosphomolybdenum method, both types of AoBTHPs showed similar antioxidant activity and no genotoxicity up to 5000 µg/plate in the Ames test. The LC-UV/DAD-ESI/MS fingerprint allowed the identification of gallic and protocatechuic acids as the two main marker compounds and the presence of catechin, epicatechin, epigallocatechin gallate, and ellagic acid in both AoBTHPs. The obtained results support the validation of red and white AoB and their THPs as anti-inflammatory agents and contribute to the possible development of promising new therapeutic options to treat inflammatory conditions. Full article
(This article belongs to the Special Issue Medicinal Plants and Their Marker Compounds—Second Edition)
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76 pages, 2178 KiB  
Systematic Review
Vitex Genus as a Source of Antimicrobial Agents
by Zohorul Islam, Gonçalo I. Caldeira, Manuela Caniça, Nurul Islam and Olga Silva
Plants 2024, 13(3), 401; https://doi.org/10.3390/plants13030401 - 29 Jan 2024
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Abstract
Vitex L. is the largest genus of the Lamiaceae family, and most of its species are used in the traditional medicinal systems of different countries. A systematic review was conducted, according to the PRISMA methodology, to determine the potential of Vitex plants as [...] Read more.
Vitex L. is the largest genus of the Lamiaceae family, and most of its species are used in the traditional medicinal systems of different countries. A systematic review was conducted, according to the PRISMA methodology, to determine the potential of Vitex plants as sources of antimicrobial agents, resulting in 2610 scientific publications from which 141 articles were selected. Data analysis confirmed that Vitex species are used in traditional medicine for symptoms of possible infectious diseases. Conducted studies showed that these medicinal plants exhibited in vitro antimicrobial activity against Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus. Vitex agnus-castus L. and Vitex negundo L. have been the most studied species, not only against bacterial strains but also against fungi such as Aspergillus niger and Candida albicans, viruses such as HIV-1, and parasites such as Plasmodium falciparum. Natural products like agnucastoside, negundol, negundoside, and vitegnoside have been identified in Vitex extracts and their antimicrobial activity against a wide range of microbial strains has been determined. Negundoside showed significant antimicrobial activity against Staphylococcus aureus (MIC 12.5 µg/mL). Our results show that Vitex species are potential sources of new natural antimicrobial agents. However, further experimental studies need to be conducted. Full article
(This article belongs to the Special Issue Medicinal Plants and Their Marker Compounds—Second Edition)
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