Synthesis and Regulation of Active Compounds in Medicinal Plants

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2855

Special Issue Editors


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Guest Editor
College of Forestry and Biotechnology, Zhejiang A&F University, Hangzhou 311300, China
Interests: orchid biotechnology; molecular biology

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Guest Editor
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China
Interests: orchid biotechnology; molecular biology

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Guest Editor
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China
Interests: regulation of bioactive metabolites in ornamental/medicinal plants
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Guest Editor
School of Life Sciences, Anhui Agricultural University, Hefei 230036, China
Interests: orchid biotechnology; molecular biology

Special Issue Information

Dear Colleagues,

Active compounds are plant-specialized metabolites, providing the basic nutritional constituents beyond the unique health benefits. They exhibit specific pharmacological activities against anti-tumor, anti-aging, anti-inflammatory, and anti-cardiovascular and cerebrovascular diseases. Additionally, they may also play a critical role in the adaptation of medicinal plants to biotic and abiotic stresses.

The present Special Issue encourages original research articles and reviews that that aim to decipher biosynthesis and regulation of active compounds in medicinal plants and their potential applications.

In particular, we invite discussions on elucidating metabolism pathways, on the application of metabolic engineering for biosynthesis of active compounds, and on metabolic networks and the regulation roles of active compounds. Studies on how active compounds are regulated by abiotic and biotic factors, exogenous elicitors or different treatments through high-throughput strategies (not limited to genomic, transcriptomic, proteomic, metabolomic, biochemical, molecular, and omics-based techniques) are also welcome. 

Dr. Jinping Si
Dr. Shunxing Guo
Dr. Zhenming Yu
Dr. Yongping Cai
Guest Editors

Manuscript Submission Information

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Keywords

  • bioinformatics
  • biosynthesis and transporter
  • gene expression and regulation
  • medicinal biotechnology
  • multi-omics analysis

Published Papers (3 papers)

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Research

17 pages, 2149 KiB  
Article
Transcriptome Analysis of Salvia miltiorrhiza under Drought Stress
by Siwei Zhang, Xinlan Qi, Ruiyan Zhu, Dongdong Ye, Minyu Shou, Lulu Peng, Minghua Qiu, Min Shi and Guoyin Kai
Plants 2024, 13(2), 161; https://doi.org/10.3390/plants13020161 - 06 Jan 2024
Cited by 1 | Viewed by 843
Abstract
Phenolic acids are one of the major secondary metabolites accumulated in Salvia miltiorrhiza with various pharmacological activities. Moderate drought stress can promote the accumulation of phenolic acids in S. miltiorrhiza, while the mechanism remains unclear. Therefore, we performed transcriptome sequencing of S. [...] Read more.
Phenolic acids are one of the major secondary metabolites accumulated in Salvia miltiorrhiza with various pharmacological activities. Moderate drought stress can promote the accumulation of phenolic acids in S. miltiorrhiza, while the mechanism remains unclear. Therefore, we performed transcriptome sequencing of S. miltiorrhiza under drought treatment. A total of 47,169 unigenes were successfully annotated in at least one of the six major databases. Key enzyme genes involved in the phenolic acid biosynthetic pathway, including SmPAL, SmC4H, Sm4CL, SmTAT, SmHPPR, SmRAS and SmCYP98A14, were induced. Unigenes annotated as laccase correlated with SmRAS and SmCYP98A14 were analyzed, and seven candidates that may be involved in the key step of SalB biosynthesis by RA were obtained. A total of 15 transcription factors significantly up-regulated at 2 h and 4 h potentially regulating phenolic acid biosynthesis were screened out. TRINITY_DN14213_c0_g1 (AP2/ERF) significantly transactivated the expression of SmC4H and SmRAS, suggesting its role in the regulation of phenolic acid biosynthesis. GO and KEGG enrichment analysis of differential expression genes showed that phenylpropanoid biosynthesis and plant hormone signal transduction were significantly higher. The ABA-dependent pathway is essential for resistance to drought and phenolic acid accumulation. Expression patterns in drought and ABA databases showed that four PYLs respond to both drought and ABA, and three potential SnRK2 family members were annotated and analyzed. The present study presented a comprehensive transcriptome analysis of S. miltiorrhiza affected by drought, which provides a rich source for understanding the molecular mechanism facing abiotic stress in S. miltiorrhiza. Full article
(This article belongs to the Special Issue Synthesis and Regulation of Active Compounds in Medicinal Plants)
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16 pages, 4614 KiB  
Article
Multivariate Analysis among Marker Compounds, Environmental Factors, and Fruit Quality of Schisandra chinensis at Different Locations in South Korea
by Dong Hwan Lee, Young-Ki Kim, Yonghwan Son, Gwang Hun Park, Hae-Yun Kwon, Youngki Park, Eung-Jun Park, Sun-Young Lee and Hyun-Jun Kim
Plants 2023, 12(22), 3877; https://doi.org/10.3390/plants12223877 - 16 Nov 2023
Viewed by 607
Abstract
This study aimed to investigate the correlation among the contents of marker compounds, growth characteristics, and environmental factors of Schisandra chinensis fruits across South Korea. The fruits were collected from 36 cultivation sites in 28 regions across the country. We investigated nine growth [...] Read more.
This study aimed to investigate the correlation among the contents of marker compounds, growth characteristics, and environmental factors of Schisandra chinensis fruits across South Korea. The fruits were collected from 36 cultivation sites in 28 regions across the country. We investigated nine growth characteristics, twelve soil physicochemical properties, eight meteorological data, and three marker compounds in this study. We optimized and validated an optimized method for quantifying marker compounds using UPLC and performed correlation analysis among the contents of marker compounds, growth characteristics, and environmental factors. The UPLC-UV method for analyzing marker compounds was validated by measuring linearity, LOD, LOQ, precision, and accuracy. The marker compounds were negatively correlated with the fruit size and sugar contents, and growth characteristics were negatively correlated with some physicochemical properties of the soil. The results of this study can be used as basic data for the standard cultural practices and quality control of S. chinensis fruits. Full article
(This article belongs to the Special Issue Synthesis and Regulation of Active Compounds in Medicinal Plants)
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11 pages, 1501 KiB  
Article
Inhibitory Activity of Natural cis-Khellactone on Soluble Epoxide Hydrolase and Proinflammatory Cytokine Production in Lipopolysaccharides-Stimulated RAW264.7 Cells
by Jang Hoon Kim, Ji Hyeon Park, Sung Cheol Koo, Yun-Chan Huh, Mok Hur, Woo Tae Park, Youn-Ho Moon, Tae Il Kim and Byoung Ok Cho
Plants 2023, 12(20), 3656; https://doi.org/10.3390/plants12203656 - 23 Oct 2023
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Abstract
The pursuit of anti-inflammatory agents has led to intensive research on the inhibition of soluble epoxide hydrolase (sEH) and cytokine production using medicinal plants. In this study, we evaluated the efficacy of cis-khellactone, a compound isolated for the first time from the [...] Read more.
The pursuit of anti-inflammatory agents has led to intensive research on the inhibition of soluble epoxide hydrolase (sEH) and cytokine production using medicinal plants. In this study, we evaluated the efficacy of cis-khellactone, a compound isolated for the first time from the roots of Peucedanum japonicum. The compound was found to be a competitive inhibitor of sEH, exhibiting an IC50 value of 3.1 ± 2.5 µM and ki value of 3.5 µM. Molecular docking and dynamics simulations illustrated the binding pose of (−)cis-khellactone within the active site of sEH. The results suggest that binding of the inhibitor to the enzyme is largely dependent on the Trp336–Gln384 loop within the active site. Further, cis-khellactone was found to inhibit pro-inflammatory cytokines, including NO, iNOS, IL-1β, and IL-4. These findings affirm that cis-khellactone could serve as a natural therapeutic candidate for the treatment of inflammation. Full article
(This article belongs to the Special Issue Synthesis and Regulation of Active Compounds in Medicinal Plants)
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