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Pharmaceutics
Special Issues
Advances and Challenges in Nasal Formulation Developments, 2nd Edition
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Advances and Challenges in Nasal Formulation Developments, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: 25 April 2024 | Viewed by 4480

Special Issue Editor

Dr. Daisuke Inoue

E-Mail Website
Guest Editor
Department of Medical Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan
Interests: nasal formulation; nasal drug delivery; mucosal absorption; CNS drug delivery; brain drug targeting; neuroinflammation; neuropathic pain; neurodegenerative diseases; sleep cycle; chronopharmacology; circadian rhythm
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Intranasal administration has the potential as a targeting system for various tissues (e.g., brain targeting, lymphatic delivery, mucosal vaccination and transmucosal absorption). The development of nasal formulations is difficult due to factors such as the retention time in the nasal cavity, dose restriction, animal species difference and individual variation in nasal drug absorption. This Special Issue will address the advances in various forms of nasal formulations, including in vivo and in vitro evaluations of drug permeation and disposition, drug dissolution from formulations, the development of novel dosage forms and excipients for nasal applications. Additionally, it will include studies on drug targeting from nose to brain/lymphatic tissue, nasal vaccination and mucosal absorption. Original research papers and review articles are welcomed.

Dr. Daisuke Inoue
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nasal formulations
  • intranasal dissolution and permeation
  • mucosal absorption
  • excipients for nasal formulations
  • in vitro dissolution system
  • in vivo nasal dissolution and absorption

Related Special Issue

Published Papers (3 papers)

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Review

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16 pages, 2240 KiB  
Review
Maltodextrin-Nanoparticles as a Delivery System for Nasal Vaccines: A Review Article
by François Fasquelle, Angelo Scuotto, Michael Howsam and Didier Betbeder
Pharmaceutics 2024, 16(2), 247; https://doi.org/10.3390/pharmaceutics16020247 - 07 Feb 2024
Viewed by 828
Abstract
Nanoparticles are increasingly being studied as antigen delivery systems for immunization with nasal vaccines. The addition of adjuvants is still generally required in many nanoparticle formulations, which can induce potential side effects owing to mucosal reactogenicity. In contrast, maltodextrin nanoparticles do not require [...] Read more.
Nanoparticles are increasingly being studied as antigen delivery systems for immunization with nasal vaccines. The addition of adjuvants is still generally required in many nanoparticle formulations, which can induce potential side effects owing to mucosal reactogenicity. In contrast, maltodextrin nanoparticles do not require additional immunomodulators, and have been shown to be efficient vaccine delivery systems. In this review, the development of maltodextrin nanoparticles is presented, specifically their physico-chemical properties, their ability to load antigens and deliver them into airway mucosal cells, and the extent to which they trigger protective immune responses against bacterial, viral, and parasitic infections. We demonstrate that the addition of lipids to maltodextrin nanoparticles increases their potency as a vaccine delivery system for nasal administration. Full article
(This article belongs to the Special Issue Advances and Challenges in Nasal Formulation Developments, 2nd Edition)
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43 pages, 2077 KiB  
Review
Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer’s Disease Management
by Sayali Dighe, Sunil Jog, Munira Momin, Sujata Sawarkar and Abdelwahab Omri
Pharmaceutics 2024, 16(1), 58; https://doi.org/10.3390/pharmaceutics16010058 - 29 Dec 2023
Cited by 2 | Viewed by 1928
Abstract
Alzheimer’s disease, a progressive neurodegenerative condition, is characterized by a gradual decline in cognitive functions. Current treatment approaches primarily involve the administration of medications through oral, parenteral, and transdermal routes, aiming to improve cognitive function and alleviate symptoms. However, these treatments face limitations, [...] Read more.
Alzheimer’s disease, a progressive neurodegenerative condition, is characterized by a gradual decline in cognitive functions. Current treatment approaches primarily involve the administration of medications through oral, parenteral, and transdermal routes, aiming to improve cognitive function and alleviate symptoms. However, these treatments face limitations, such as low bioavailability and inadequate permeation. Alternative invasive methods, while explored, often entail discomfort and require specialized assistance. Therefore, the development of a non-invasive and efficient delivery system is crucial. Intranasal delivery has emerged as a potential solution, although it is constrained by the unique conditions of the nasal cavity. An innovative approach involves the use of nano-carriers based on nanotechnology for intranasal delivery. This strategy has the potential to overcome current limitations by providing enhanced bioavailability, improved permeation, effective traversal of the blood–brain barrier, extended retention within the body, and precise targeting of the brain. The comprehensive review focuses on the advancements in designing various types of nano-carriers, including polymeric nanoparticles, metal nanoparticles, lipid nanoparticles, liposomes, nanoemulsions, Quantum dots, and dendrimers. These nano-carriers are specifically tailored for the intranasal delivery of therapeutic agents aimed at combatting Alzheimer’s disease. In summary, the development and utilization of intranasal delivery systems based on nanotechnology show significant potential in surmounting the constraints of current Alzheimer’s disease treatment strategies. Nevertheless, it is essential to acknowledge regulatory as well as toxicity concerns associated with this route; meticulous consideration is required when engineering a carrier. This comprehensive review underscores the potential to revolutionize Alzheimer’s disease management and highlights the importance of addressing regulatory considerations for safe and effective implementations. Embracing this strategy could lead to substantial advancements in the field of Alzheimer’s disease treatment. Full article
(This article belongs to the Special Issue Advances and Challenges in Nasal Formulation Developments, 2nd Edition)
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Other

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17 pages, 795 KiB  
Systematic Review
The Efficacy and Safety of Intranasal Formulations of Ketamine and Esketamine for the Treatment of Major Depressive Disorder: A Systematic Review
by Ludivine Boudieu, Myriam Mennetrier, Pierre-Michel Llorca and Ludovic Samalin
Pharmaceutics 2023, 15(12), 2773; https://doi.org/10.3390/pharmaceutics15122773 - 13 Dec 2023
Cited by 1 | Viewed by 1185
Abstract
Ketamine and its enantiomers represent an innovative glutamatergic agent as a treatment for individuals with treatment-resistant depression (TRD) and major depressive disorder (MDD) with suicidal ideation and behavior. Intranasal (IN) formulations could allow for quick onset of action on depressive symptoms as well [...] Read more.
Ketamine and its enantiomers represent an innovative glutamatergic agent as a treatment for individuals with treatment-resistant depression (TRD) and major depressive disorder (MDD) with suicidal ideation and behavior. Intranasal (IN) formulations could allow for quick onset of action on depressive symptoms as well as a reduction in side effects by bypassing the blood–brain barrier compared with administration via the intravenous route. The aim of this review was to provide an up-to-date analysis of the data on the efficacy and safety of IN ketamine and IN esketamine for the treatment of MDD. A systematic review following PRISMA guidelines was conducted. Databases (PubMed, Embase, MEDLINE, PsycINFO, and Google Scholar) were searched to capture articles about IN ketamine or IN esketamine for MDD. This systematic review highlighted the interest in IN routes of ketamine and esketamine for MDD patients with TRD or active suicidal ideation. They provide a rapid onset of antidepressant action within the first hours after administration. Nevertheless, the evidence of efficacy is stronger for IN esketamine than for IN ketamine in MDD patients. The safety profile appears to be acceptable for IN esketamine but requires further studies, and a more accurate IN delivery device is required for ketamine. Full article
(This article belongs to the Special Issue Advances and Challenges in Nasal Formulation Developments, 2nd Edition)
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