Mass Spectrometry Imaging in Pharmaceutical Research

Dear Colleagues,

Mass spectrometry imaging (MSI) enables the spatially resolved analysis of drugs, drug metabolites, metabolic pathways, proteins, lipids and glycans in human and animal tissues and in 3D cell culture model of disease. Since MSI is unique in that it neither requires reagents nor labels but relies primarily on accurate measurement of molecular masses instead, it has recently become a mainstay in pharmaceutical research and drug development.

This special issue of “Pharmaceuticals” highlights cutting-edge developments in MSI instrumentation, in information technology and data science as well as in experimental MSI workflows for pharmaceutical research. It also features innovative applications of MSI in drug metabolism and pharmacokinetics (DMPK), in pharmaceutical veterinary pathology, in validation and experimental investigation of animal and tissue culture models of disease, and in toxicology and drug safety assessment. Finally, this special issue points to the discovery, interpretation and use of complex molecular signatures as future pharmacodynamic or efficacy biomarkers in preclinical pharmaceutical research and in clinical drug development.

Prof. Dr. Carsten Hopf
Dr. Stefania-Alexandra Iakab
Dr. Michael Becker
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.