Dear colleagues,

Rheumatoid arthritis (RA) is a multifactorial disease that involves both genetic predisposition and environmental components. In 2019, there were 18 million RA patients worldwide. Aproximately 70% of RA patients are women, and 55% are older than 55 years. Thirteen million people with rheumatoid arthritis experience severity levels (moderate or severe) that could benefit from rehabilitation. RA is characterized by chronic inflammation of the synovial membrane that lines the joints, damage to the cartilage, and erosion of the bone. Bioactive compounds are dietary ingredients that provide beneficial health effects to functional foods and nutraceuticals. These compounds exhibit antioxidant and anti-inflammatory activities, as well as additional preventative properties. Bioactive compounds found in natural food products can control arthritic inflammation through multiple pathways, for example the inhibition of effector molecules (e.g., cytokines and chemokines), induction of anti-inflammatory mediators (e.g., IL-4, IL-10), regulation of the Th17/Treg balance, and modulation of osteo-immune cross-talk.

Dr. Luís Manuel Lopes Rodrigues Da Silva
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• bioactive compounds
• functional foods
• nutraceuticals
• rheumatoid arthritis
• anti-inflamatory activity
• anti-inflammatory mediators