Pharmacological Innovations for Healthy Ageing Throughout Life
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 119
Special Issue Editor
Interests: pharmacoepidemiology; biostatistics; geriatric syndromes; multimorbidity; frailty; chronic kidney disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleague,
The age of the global population is accelerating at an unprecedented pace, profoundly reshaping healthcare systems and placing increasing demands on pharmaceutical research and therapeutic innovation. Ageing is accompanied by progressive biological, physiological, and functional changes that modify disease presentation, drug metabolism, pharmacokinetics, and pharmacodynamics, while multimorbidity and polypharmacy substantially increase the risk of adverse drug events. Despite these challenges, older adults remain underrepresented in clinical trials, and age-specific therapeutic strategies are still insufficiently integrated into drug development pipelines. This Special Issue focuses on pharmacological innovations for healthy ageing across the lifespan, aiming to bridge fundamental ageing biology with translational research and clinical pharmacotherapy. We invite contributions that explore molecular and cellular mechanisms of ageing, identification of druggable ageing pathways, and development of novel or repurposed compounds targeting age-related diseases and multimorbidity. Particular emphasis is placed on precision and geriatric pharmacology, pharmacogenomics, medication optimization, deprescribing strategies, and real-world evidence supporting safer and more effective treatment in ageing populations. In addition, this Special Issue welcomes studies leveraging emerging methodologies such as artificial intelligence, machine learning, digital biomarkers, and advanced pharmacoepidemiological approaches to inform drug discovery, evaluation, and post-marketing surveillance in older adults. By integrating mechanistic insights, clinical evidence, and innovative analytical tools, this collection aims to promote a paradigm shift toward personalized, safe, and sustainable pharmacological interventions that enhance functional ability, resilience, and quality of life throughout ageing.
Dr. Luca Soraci
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
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Keywords
- age-related diseases
- pharmacological innovations
- adverse drug events
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