Applications of EPR Spectroscopy in Pharmaceutical Research
A Special Issue of Pharmaceuticals (ISSN 1424-8247) belonging to the section "Pharmacology".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 190
Editors
Interests: EPR spectroscopy; free radicals; spin trapping; single-crystal EPR spectroscopy; biostatistics
Special Issue Information
Dear Colleagues,
Electron paramagnetic resonance (EPR) spectroscopy is a highly specific analytical technique that enables the direct detection and characterization of paramagnetic species, including free radicals, transition metal complexes, spin labels, and spin probes. In pharmaceutical research, these species are relevant to oxidative stress, drug metabolism, antioxidant activity, drug-induced toxicity, photodegradation, sterilization-induced radical formation, and the stability of pharmaceutical formulations.
EPR spectroscopy can support multiple stages of drug discovery, development, and quality assessment. It is used to evaluate radical-scavenging activity, identify reactive intermediates involved in drug action, investigate drug-membrane interactions, monitor oxidative degradation pathways, and characterize paramagnetic metallodrugs. Spin probes and spin labels further enable the study of drug delivery systems, including liposomes, polymeric carriers, micro- and nanoparticles.
Recent advances in benchtop instrumentation, spectral simulation tools, spin-trapping methods, and in vivo EPR approaches have expanded the accessibility and relevance of this technique in pharmaceutical sciences.
In this Special Issue, we welcome original research articles and reviews addressing current applications and future directions of EPR spectroscopy in pharmaceutical research.
Dr. Erim Bešić
Dr. Davor Šakić
Guest Editors
Manuscript Submission Information
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Keywords
- EPR spectroscopy
- pharmaceutical research
- free radicals
- spin trapping
- spin labels
- oxidative stress
- antioxidant activity
- drug stability
- drug delivery
- metallodrugs
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