Pharmacotherapy of Neurodegeneration Disorders

Dear Colleagues,

A significant increase in the ageing of populations worldwide is especially prevalent in recent decades, with age-related rates steadily increasing. The progressive degeneration and/or death of neuronal cells, resulting in the manifestation of motor (ataxia) and mental disorders (dementia), is linked to a number of neurodegenerative diseases, characterized by the loss of neurons in certain areas of the brain. The current therapeutic strategies in neurodegenerative diseases are mainly aimed at influencing various symptoms, where increasing interest is paid to the key role of oxidative stress and inflammatory processes in the pathogenesis of neurodegenerative diseases. In this relationship, the isolation or synthesis of various biologically active molecules with potential anti-inflammatory and antioxidant effects would expand approaches for the therapy of these diseases beyond conventional treatment, which is accompanied by the manifestation of a number of adverse drug reactions. In addition, the search and the design of new chemically available multitarget agents will add to the search for contemporaneous strategies in neurodegenerative tratment.

Prof. Dr. Magdalena Kondeva-Burdina
Prof. Dr. Maya Georgieva
Guest Editors

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