Discovery and Evaluation of Essential Oils with Pharmaceutical Potentials

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 257

Editors


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Guest Editor
Department of Chemistry, Federal Institute of Education, Sciences and Technology Goiano, Urutaí 75790-000, GO, Brazil
Interests: chemistry of natural products; essential oils; gas-phase ion chemistry; structural elucidation

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Guest Editor

Special Issue Information

Dear Colleagues,

Natural product chemistry is an abundant source of biologically active compounds applied in various industries, particularly in the development of medicines, drug discovery, pharmacological products, the food industry, polymers, and more. Natural products contain unique metabolites like essential oils, alkaloids, saponins, neolignane, lignans, flavonoids, etc., which are produced by plants or marine organisms as part of their secondary metabolism. Throughout history, humans have utilized these compounds in traditional culinary and folk medicine practices, recognizing them as sources of beneficial substances that have a wide range of biological effects, such as antibiotic, anti-inflammatory, and immune-boosting effects as well as antifungal properties, ultimate improving the quality of life for consumers. However, the rise resistance to commercial drugs has led to an increase in focus on discovering novel substances, particularly from natural products, that can aid in the treatment of traditional, neglected, and multi-resistant diseases. One of the classes of bioactive compounds that can be highlighted that may be used as an alternative to treat such diseases is essential oils. This class of substances have a wide range of pharmacological properties, including antiviral, antifungal, and immunomodulatory effects, which contribute to their therapeutic potential. Moreover, their ability to act synergistically with conventional drugs can enhance treatment efficacy while reducing side effects.

This Special Issue aims to gather original articles that highlight new methods, approaches, or trends, as well as the multiple applications of essential oils. Review articles are also encouraged, particularly those that address trends and challenges in analytical chemistry applied to natural products.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • New trends in the extraction, purification, isolation, and characterization of essential oils.
  • Applications of essential oils as potential antimicrobial agents.
  • Applications of essential oils as potential antifungal drugs.
  • Applications of essential oils against tropical neglected diseases.
  • The use of mass spectrometry as a tool for bioprospecting essential oils.
  • Emerging trends in spectroscopic methods applied to dereplication of essential oils.
  • Physicochemical analysis of essential oils as a tool for elucidating compounds in complex mixtures.
  • Validating of analytical techniques used in the pharmaceutic industry.

We look forward to receiving your contributions.

Prof. Dr. Herbert Júnior Dias
Dr. Noelia Duarte
Guest Editors

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Keywords

  • natural products
  • spectroscopic methods
  • spectrometric methods
  • bioprospection
  • structural characterization
  • secondary metabolism
  • volatile compounds

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Published Papers (1 paper)

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Research

26 pages, 3060 KB  
Article
Chemical Composition and Antibacterial Activity Against Food-Borne Pathogens of Six Essential Oils from Plants in Northeastern Peru
by Laydy Mitsu Mena-Chacon, Krizia Pretell, Angel F. Huaman-Pilco, Yuriko Saavedra, Aline Camila Caetano, Diner Mori-Mestanza, Robin Oblitas-Delgado, Carlos A. Amasifuen-Guerra, Rocio Jara-Vilca, Roberth Esteve Iliquin-Fernandez and Segundo Chávez-Quintana
Pharmaceuticals 2026, 19(6), 951; https://doi.org/10.3390/ph19060951 (registering DOI) - 18 Jun 2026
Abstract
Background: Essential oils (EOs) are promising natural antimicrobials against food-borne pathogens, yet their efficacy depends on complex chemical profiles that vary by species and origin. The evaluation of underexplored aromatic plants from the Peruvian Amazon may reveal novel bioactive agents. Methods: We chemically [...] Read more.
Background: Essential oils (EOs) are promising natural antimicrobials against food-borne pathogens, yet their efficacy depends on complex chemical profiles that vary by species and origin. The evaluation of underexplored aromatic plants from the Peruvian Amazon may reveal novel bioactive agents. Methods: We chemically characterized six EOs from Aloysia citrodora, Arracacia xanthorrhiza (two cultivars), Baccharis genistelloides, Piper acutifolium, and Piper lanceifolium using GC-MS and assessed their antibacterial activity against Escherichia coli (ATCC 25922), Salmonella enterica (ATCC 14028), Enterococcus faecalis (ATCC 29212), and Staphylococcus aureus (ATCC 49476). Results: EOs of Aloysia citrodora and Arracacia xanthorrhiza cv. Yellow exhibited the strongest inhibition, effective against both Gram-positive and Gram-negative bacteria, potentially associated with higher relative abundances of oxygenated monoterpenes and aliphatic aldehydes. Dose–response analysis supported their superior antibacterial potency, with the lowest LD50 values observed for these oils. Oils rich in sesquiterpenes showed lower activity. Conclusions: These findings underscore the importance of EO chemical composition for antibacterial potency and suggest that select Amazonian EOs have potential as natural preservatives for food safety applications. Full article
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