Advances in Pediatric Drug Formulations

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".

Deadline for manuscript submissions: 25 February 2025 | Viewed by 1322

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 41 V. Babes Street, 400012 Cluj-Napoca, Romania
Interests: orodispersible dosage forms; pediatric dosage forms; freeze-drying; quality by design drug development; product/process optimization; design of experiments; texture analysis in pharmaceutical product characterization
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E-Mail Website
Guest Editor
Department of Pharmaceutical Technology and Biopharmacy, University of Medicine and Pharmacy “Iuliu Hațieganu”, 41 Victor Babeș Street, 400012 Cluj-Napoca, Romania
Interests: innovative dosage forms; drug delivery systems; quality by design (QbD); process analytical technology (PAT); multivariate data analysis (MVDA); 3D printing in pharmaceutics; novel methods of drugs manufacturing; pharmaceutical process optimization
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Dermopharmacy and Cosmetics, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 12 I. Creanga Street, 400010 Cluj-Napoca, Romania
Interests: development and characterization of solid and semisolid dosage forms; texture analysis; development and optimization of cosmetic products based on nanocarriers or herbal extracts
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The low availability of appropriate pediatric medications remains a focal point for researchers and pharmaceutical manufacturing companies. Although efforts have been made to stimulate the authorization of pediatric medications, the needs of patients are still far away from being fulfilled. Lately, new solid dosage forms, such as orodispersibles, minitablets, thin films, and 3D-printed dosage forms, have been proposed as alternatives to liquids for different age groups, along with novel devices that ease pediatric drug administration. However, this field requires further research and innovation in terms of the appropriate excipients, product and process development, taste masking, and quality assessment methods. Also, understanding end-user perception and acceptability is needed to guide product formulation and grant treatment adherence. While pediatric drug availability, as well as details on preparation, manipulation, administration practices, and preferences, have long been documented in developed countries, data coming from developing regions are scarce.

We extend an invitation to all stakeholders, including academia, pharmaceutical companies, hospital/community pharmacies, patient associations, and regulatory authorities, to share their results in the aforementioned matters and bridge the knowledge gaps that currently limit the development of pediatric drugs.

Dr. Sonia M. Iurian
Prof. Dr. Ioan Tomuță
Dr. Catalina Bogdan
Guest Editors

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Keywords

  • pediatric dosage forms
  • child-friendly dosage forms
  • age-appropriate dosage forms
  • acceptability
  • administration devices
  • taste-masking
  • compounded pediatric formulations

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Published Papers (1 paper)

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Research

20 pages, 8678 KiB  
Article
Exploring Vacuum Compression Molding as a Preparation Method for Flexible-Dose Pediatric Orodispersible Films
by Dana Hales, Cătălina Bogdan, Lucia Ruxandra Tefas, Andreea Cornilă, Maria-Andreea Chiver, Ioan Tomuță, Tibor Casian, Rareș Iovanov, Gábor Katona, Rita Ambrus and Sonia Iurian
Pharmaceuticals 2024, 17(7), 934; https://doi.org/10.3390/ph17070934 - 12 Jul 2024
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Abstract
In recent years, solid dosage forms have gained interest in pediatric therapy because they can provide valuable benefits in terms of dose accuracy and stability. Particularly for orodispersible films (ODFs), the literature evidences increased acceptability and dose flexibility. Among the various available technologies [...] Read more.
In recent years, solid dosage forms have gained interest in pediatric therapy because they can provide valuable benefits in terms of dose accuracy and stability. Particularly for orodispersible films (ODFs), the literature evidences increased acceptability and dose flexibility. Among the various available technologies for obtaining ODFs, such as solvent casting, hot-melt extrusion, and ink printing technologies, the solvent-free preparation methods exhibit significant advantages. This study investigated Vacuum Compression Molding (VCM) as a solvent-free manufacturing method for the preparation of flexible-dose pediatric orodispersible films. The experimental approach focused on selecting the appropriate plasticizer and ratios of the active pharmaceutical ingredient, diclofenac sodium, followed by the study of their impacts on the mechanical properties, disintegration time, and drug release profile of the ODFs. Additional investigations were performed to obtain insights regarding the solid-state properties. The ODFs obtained by VCM displayed adequate quality in terms of their critical characteristics. Therefore, this proof-of-concept study shows how VCM could be utilized as a standalone method for the production of small-scale ODFs, enabling the customization of doses to meet the individual needs of pediatric patients. Full article
(This article belongs to the Special Issue Advances in Pediatric Drug Formulations)
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