Recent Advances in Pharmaceutical Formulation

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 481

Special Issue Editors


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Guest Editor
Drug Industry and Pharmaceutical Biotechnology Department, Faculty of Pharmacy, “Grigore T. Popa”, University of Medicine and Pharmacy from Iași, 700115 Iasi, Romania
Interests: pharmaceutical formulation

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Guest Editor
Pharmaceutical Technology and Cosmetology Department, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania
Interests: hydrogels; oleogels; bigels; pharmaceutical formulation; orodispersible tablets
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Guest Editor
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Interests: pharmaceutical development; innovative dosage forms; 3D printing in pharmaceutics; quality by design (QbD); process analytical technology (PAT); multivariate data analysis (MVDA); pharmaceutical product/process optimization
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pharmaceutical formulation is a critical stage in the development of any medicinal product, as the accuracy and scientific rigor applied at this step largely determine the success of subsequent research and clinical phases. The growing need for personalized therapies has highlighted the limitations of standardized industrial products, as patient-specific factors, such as genetic testing results, intolerances, or therapeutic inefficacy, often require individualized approaches. In this context, magistral and compounded preparations are gaining renewed attention as flexible solutions adapted to unique patient needs. Examples include the preparation of capsules with diverse active substances for patients with specific intolerances, topical formulations in dermatology using transdermal bases, or ovules containing thermolabile compounds that cannot be manufactured on an industrial scale. These practices are fostering the development of a distinctive niche for pharmacists engaged in laboratory compounding, a domain that stands at the intersection of art and science.

This Special Issue aims to gather innovative research contributions and critical reviews on the formulation of personalized and compounded preparations. Topics of interest include sustainable excipients, preformulated bases, advanced drug delivery platforms, and efficient strategies for adapting formulations to individual therapeutic requirements. By bridging traditional practices with modern technologies, this volume seeks to advance the field of pharmaceutical formulation in both academic and clinical settings.

Dr. Magdalena Bîrsan
Dr. Robert-Alexandru Vlad
Prof. Dr. Ioan Tomuta
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sustainable excipients
  • preformulated bases
  • drug delivery platforms
  • pharmaceutical formulation
  • personalized therapies

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Published Papers (1 paper)

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Research

23 pages, 1481 KB  
Article
Formulation and Analytical Evaluation of Liquid Cannabidiol Preparations: Comparative Study of Oil-Based Solutions and Emulsions
by Robert-Alexandru Vlad, Lénárd Farczádi, Denisa Paliștan, Cezara Pintea, Paula Antonoaea, Emöke-Margit Rédai, Andrada Pintea, Cornelia-Titiana Cotoi, Adriana Ciurba, Magdalena Bîrsan and Ruxandra-Emilia Ștefănescu
Pharmaceutics 2025, 17(12), 1533; https://doi.org/10.3390/pharmaceutics17121533 - 28 Nov 2025
Viewed by 298
Abstract
Background/Objectives: Cannabidiol (CBD) is a non-psychoactive compound found in the Cannabis sativa plant. Due to its broad therapeutic potential, CBD is often incorporated into various pharmaceutical formulations. This study aimed to evaluate homogenous (oil-based) and heterogeneous (emulsion-based) liquid preparations of CBD using [...] Read more.
Background/Objectives: Cannabidiol (CBD) is a non-psychoactive compound found in the Cannabis sativa plant. Due to its broad therapeutic potential, CBD is often incorporated into various pharmaceutical formulations. This study aimed to evaluate homogenous (oil-based) and heterogeneous (emulsion-based) liquid preparations of CBD using different fatty oils and provide a comprehensive comparative framework for the development of stable liquid dosage forms of cannabidiol (CBD), with direct applications in pharmaceutical formulations. Methods: The oils and emulsions were qualitatively analysed to assess their stability and suitability as CBD carriers. Ultraviolet (UV) spectrophotometry and High-Performance Liquid Chromatography (HPLC) were employed for quantifying CBD in the formulations and also characterising them in terms of product quality. Results: The results indicated that sunflower oil is the most stable and analytically compatible matrix, with CBD recovery close to 100% and minimal degradation over time. Conversely, linseed and pumpkin seed oils exhibited significant analytical interference and oxidative instability. Oil-in-water emulsions prepared with a 4% Tween 80/Span 80 mixture demonstrated optimal physical stability and droplet size distribution. Conclusions: Overall, both formulations can be regarded as suitable pharmaceutical carriers for CBD delivery. Full article
(This article belongs to the Special Issue Recent Advances in Pharmaceutical Formulation)
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