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Article

The Role of Interleukine-10 and Interferon-γ as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar

1
VISAVET Health Surveillance Center, Complutense University of Madrid, 28040 Madrid, Spain
2
Department of Animal Health, Faculty of Veterinary, Complutense University of Madrid, 28040 Madrid, Spain
*
Author to whom correspondence should be addressed.
These authors have contributed equally to this work.
Academic Editor: Pedro J. Sánchez-Cordón
Pathogens 2021, 10(6), 757; https://doi.org/10.3390/pathogens10060757
Received: 17 May 2021 / Revised: 3 June 2021 / Accepted: 11 June 2021 / Published: 15 June 2021
(This article belongs to the Special Issue African Swine Fever Virus Infection)
African swine fever virus (ASFv) is one of the most challenging pathogens to affect both domestic and wild pigs. The disease has now spread to Europe and Asia, causing great damage to the pig industry. Although no commercial vaccine with which to control the disease is, as yet, available, some potential vaccine candidates have shown good results in terms of protection. However, little is known about the host immune mechanisms underlying that protection, especially in wild boar, which is the main reservoir of the disease in Europe. Here, we study the role played by two cytokines (IL-10 and IFN-γ) in wild boar orally inoculated with the attenuated vaccine candidate Lv17/WB/Rie1 and challenged with a virulent ASFv genotype II isolate. A group of naïve wild boar challenged with the latter isolate was also established as a control group. Our results showed that both cytokines play a key role in protecting the host against the challenge virus. While high levels of IL-10 in serum may trigger an immune system malfunctioning in challenged animals, the provision of stable levels of this cytokine over time may help to control the disease. This, together with high and timely induction of IFN-γ by the vaccine candidate, could help protect animals from fatal outcomes. Further studies should be conducted in order to support these preliminary results and confirm the role of these two cytokines as potential markers of the evolution of ASFV infection. View Full-Text
Keywords: ASF; cytokines; IL-10; IFN-γ; wild boar; vaccine candidate ASF; cytokines; IL-10; IFN-γ; wild boar; vaccine candidate
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MDPI and ACS Style

Barroso-Arévalo, S.; Barasona, J.A.; Cadenas-Fernández, E.; Sánchez-Vizcaíno, J.M. The Role of Interleukine-10 and Interferon-γ as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar. Pathogens 2021, 10, 757. https://doi.org/10.3390/pathogens10060757

AMA Style

Barroso-Arévalo S, Barasona JA, Cadenas-Fernández E, Sánchez-Vizcaíno JM. The Role of Interleukine-10 and Interferon-γ as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar. Pathogens. 2021; 10(6):757. https://doi.org/10.3390/pathogens10060757

Chicago/Turabian Style

Barroso-Arévalo, Sandra, Jose A. Barasona, Estefanía Cadenas-Fernández, and Jose M. Sánchez-Vizcaíno 2021. "The Role of Interleukine-10 and Interferon-γ as Potential Markers of the Evolution of African Swine Fever Virus Infection in Wild Boar" Pathogens 10, no. 6: 757. https://doi.org/10.3390/pathogens10060757

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