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Molecular Characterization of African Swine Fever Virus Isolates in Estonia in 2014–2019
Article

Comparative Pathology of Domestic Pigs and Wild Boar Infected with the Moderately Virulent African Swine Fever Virus Strain “Estonia 2014”

Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany
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Pathogens 2020, 9(8), 662; https://doi.org/10.3390/pathogens9080662
Received: 29 July 2020 / Revised: 12 August 2020 / Accepted: 13 August 2020 / Published: 16 August 2020
(This article belongs to the Special Issue African Swine Fever Virus Infection)
Endemically infected European wild boar are considered a major reservoir of African swine fever virus in Europe. While high lethality was observed in the majority of field cases, strains of moderate virulence occurred in the Baltic States. One of these, “Estonia 2014”, led to a higher number of clinically healthy, antibody-positive animals in the hunting bag of North-Eastern Estonia. Experimental characterization showed high virulence in wild boar but moderate virulence in domestic pigs. Putative pathogenic differences between wild boar and domestic pigs are unresolved and comparative pathological studies are limited. We here report on a kinetic experiment in both subspecies. Three animals each were euthanized at 4, 7, and 10 days post infection (dpi). Clinical data confirmed higher virulence in wild boar although macroscopy and viral genome load in blood and tissues were comparable in both subspecies. The percentage of viral antigen positive myeloid cells tested by flow cytometry did not differ significantly in most tissues. Only immunohistochemistry revealed consistently higher viral antigen loads in wild boar tissues in particular 7 dpi, whereas domestic pigs already eliminated the virus. The moderate virulence in domestic pigs could be explained by a more effective viral clearance. View Full-Text
Keywords: African swine fever virus; virulence; pathology; wild boar; domestic pig; macroscopy; histopathology; immunology African swine fever virus; virulence; pathology; wild boar; domestic pig; macroscopy; histopathology; immunology
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MDPI and ACS Style

Sehl, J.; Pikalo, J.; Schäfer, A.; Franzke, K.; Pannhorst, K.; Elnagar, A.; Blohm, U.; Blome, S.; Breithaupt, A. Comparative Pathology of Domestic Pigs and Wild Boar Infected with the Moderately Virulent African Swine Fever Virus Strain “Estonia 2014”. Pathogens 2020, 9, 662. https://doi.org/10.3390/pathogens9080662

AMA Style

Sehl J, Pikalo J, Schäfer A, Franzke K, Pannhorst K, Elnagar A, Blohm U, Blome S, Breithaupt A. Comparative Pathology of Domestic Pigs and Wild Boar Infected with the Moderately Virulent African Swine Fever Virus Strain “Estonia 2014”. Pathogens. 2020; 9(8):662. https://doi.org/10.3390/pathogens9080662

Chicago/Turabian Style

Sehl, Julia, Jutta Pikalo, Alexander Schäfer, Kati Franzke, Katrin Pannhorst, Ahmed Elnagar, Ulrike Blohm, Sandra Blome, and Angele Breithaupt. 2020. "Comparative Pathology of Domestic Pigs and Wild Boar Infected with the Moderately Virulent African Swine Fever Virus Strain “Estonia 2014”" Pathogens 9, no. 8: 662. https://doi.org/10.3390/pathogens9080662

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