Medication-Related Osteonecrosis of the Jaw (MRONJ): Current Practice, New Tools and Future Trends

Dear Colleagues,

Medication-related osteonecrosis of the Jaw (MRONJ) is an adverse drug reaction described as the progressive destruction and death of bone that affects the mandible and maxilla of patients exposed to the treatment with medications known to increase the risk of disease, in the absence of a previous radiation treatment.

Osteonecrosis of the jaw has been described for the first time more than 15 years ago; since that time, thousands of paper have been published on the topic, showing the progress of research in this area. What we know is that MRONJ may lead to a reduced quality of life due to jaw bone infections, chronic pain, tooth loss, impaired function, and disfigurement. However, despite significant advancement in our comprehension of the disease, there remain several controversial issues.

Indeed, one of the most recurrent question is “Which is the correct treatment strategy for patients affected by MRONJ?”

Simultaneously, surgical techniques have advanced considerably and several new tools have been proposed, such as lasers or piezoelectric devices. Additionally, team-based multidisciplinary patient management has been applied in MRONJ prevention and treatment, improving patient outcomes beyond traditional operative strategies.

This Topical Collection is focused on, but not limited to, advances and innovations in MRONJ treatment highlighting novel surgical approaches or devices and outcomes of clinical management protocols.

We invite you to submit high-quality original research articles or reviews that provide new findings on MRONJ extending the current state of knowledge. All manuscripts will be peer-reviewed by experts in the field.

Prof. Dr. Giacomo Oteri
Prof. Dr. Umberto Romeo
Dr. Rodolfo Mauceri
Prof. Dr. Alberto Bedogni
Dr. Vittorio Fusco
Collection Editors

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