Targeting Abnormal Cell Cycle in Cancer
A special issue of Onco (ISSN 2673-7523).
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 5527
Special Issue Editors
Interests: oncogene; tumor suppressor; tumor metabolism; RB; Ras; RECK
Special Issues, Collections and Topics in MDPI journals
Interests: cell cycle; G1 progression; tumorigenesis; cancer metabolism; ROS regulation; leukemogenesis; lipid metabolism
Special Issue Information
Dear Colleagues,
A variety of oncogenic signals merge on the upregulation of D-type cyclins and, thus, many of the molecular targeting drugs attenuate abnormal cell proliferation by suppressing kinases whose function is dependent on cyclins. Synthetic CDK4/6 inhibitors exert antitumor effects by maintaining RB1 in an unphosphorylated state, causing cell cycle arrest in G1 phase, cellular senescence, apoptosis and increased immunogenicity. The successful result of breast cancer treatment by CDK4/6 inhibitors in combination with endocrine therapy has demonstrated that targeting the key machinery of cell cycle control bears significant clinical benefits. This Special Issue will highlight basic and clinical studies that aim to develop novel or improved therapeutic strategies targeting abnormal cell cycle in cancer.
Prof. Dr. Chiaki Takahashi
Prof. Dr. Jun-ya Kato
Guest Editors
Manuscript Submission Information
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Keywords
- RB
- CDK
- cancer therapy
- resistance
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