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Onco
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The Evolving Landscape of Contemporary Cancer Therapies
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The Evolving Landscape of Contemporary Cancer Therapies

A special issue of Onco (ISSN 2673-7523).

Deadline for manuscript submissions: 31 May 2025 | Viewed by 2881

Special Issue Editor

Dr. Constantin N. Baxevanis

E-Mail Website
Guest Editor
Cancer Immunology and Immunotherapy Center, Cancer Research Center, Saint Savas Cancer Hospital, 171 Alexandras Av., 11522 Athens, Greece
Interests: cancer immunology; cancer immunotherapy; biomarkers; precision oncology; immune resistance; cancer vaccines; immune escape; immune checkpoint inhibitors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A new era of cancer therapeutic modalities, including immunotherapies and targeted therapies, has led to a paradigm shift in cancer treatment, inducing effective and durable clinical responses for a significant number of patients suffering from various types of malignancy. Combinatorial treatments, including immune checkpoint inhibitors, adoptive cellular therapies, molecular targeted therapies, and cancer vaccines, have helped in overcoming cancer heterogeneity, inducing resistance mechanisms, and thus reinforce the impact of these novel cancer therapeutic approaches. However, despite this success, a substantial number of patients do not respond to these therapeutic regimens, which underlines the necessity of determining ways to predict the clinical responses to treatment. We are delighted to invite you to contribute to this Special Issue, which will spotlight advancements in clinical and translational research within cancer immunotherapy. We welcome both original research articles and comprehensive reviews. The scientific areas to be covered include, but are not limited to, the following: (a) predictive biomarkers for cancer immunotherapies and targeted therapies; (b) mechanisms of action that are implicated in the immunotherapeutic and targeted modalities associated with the treatment of malignancy; (c) clinical trials investigating the efficacy and safety of cancer immunotherapy and targeted therapy regimens; (d) strategies for immunomodulation, counteracting resistance, and mitigating adverse events; and (e) the emerging role of the microbiome as a regulator of immunotherapies. Submissions addressing novel approaches to adapting clinical trial designs for the advancement of immunotherapy are also encouraged. We strongly believe that our Special Issue will enhance our understanding of tumor evolution and promote the design and application of more effective treatment strategies.

Dr. Constantin N. Baxevanis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Onco is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer immunotherapy
  • targeted cancer therapies
  • immune resistance
  • immunomodulation
  • cancer biomarkers

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Published Papers (2 papers)

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10 pages, 752 KiB  
Article
Impact of Physical Exercise on Quality of Life, Self-Esteem, and Depression in Breast Cancer Survivors: A Pilot Study
by Eduarda Maria Rocha Teles de Castro Coelho, Helena Isabel Azevedo Mendes, Carla Afonso Varajidás and Sandra Celina Fernandes Fonseca
Onco 2024, 4(3), 207-216; https://doi.org/10.3390/onco4030015 - 22 Aug 2024
Viewed by 1298
Abstract
Controlled study designs usually report that physical exercise improves the health of women living with breast cancer. However, many of these women are not sufficiently active to experience the benefits of exercise. The main objective was to analyze the effect of a physical [...] Read more.
Controlled study designs usually report that physical exercise improves the health of women living with breast cancer. However, many of these women are not sufficiently active to experience the benefits of exercise. The main objective was to analyze the effect of a physical exercise program on quality of life, self-esteem, and depression in breast cancer survivors. Thirteen participants (46.54 ± 6.31 years old) completed the exercise intervention. Three patient-reported questionnaires were used: Supplementary Questionnaire Breast Cancer Module (QLQ-BR23), Beck Depression Inventory (BDI), and Rosenberg Self-Esteem Scale (RSES). All participants had significantly improved self-esteem (p = 0.004). Although there were no statistically significant changes in depression, there was a notable decrease in scores (6.39 ± 4.75 vs. 5.00 ± 4.75; p = 0.080). Regarding quality of life, significant improvements were observed in “future perspectives” (p = 0.047) and “arm symptoms” (p = 0.015). No significant changes were noted in the other variables. Our results suggest that physical exercise is an effective strategy that positively affects breast cancer survivors’ quality of life and self-esteem. The results reinforce the need for community-based exercise programs for breast cancer survivors. Healthcare professionals should promote physical exercise to improve health outcomes before, during, and after treatment. Full article
(This article belongs to the Special Issue The Evolving Landscape of Contemporary Cancer Therapies)
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Review

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14 pages, 848 KiB  
Review
The Emerging Applications of Raman Spectroscopy in Clinical Oncology: A Narrative Review Focused on Circulating Tumor DNA Detection and Therapeutic Drug Monitoring
by Sathya Narayanan, Yuling Wang and Howard Gurney
Onco 2024, 4(4), 335-348; https://doi.org/10.3390/onco4040023 - 16 Oct 2024
Viewed by 810
Abstract
Raman spectroscopy is a technique which involves quantitative and qualitative molecular analysis based on the interaction between incident light and isolation of scattered wavelengths in generating a molecular fingerprint. It has a broad array of potential scientific applications, encompassing areas as diverse as [...] Read more.
Raman spectroscopy is a technique which involves quantitative and qualitative molecular analysis based on the interaction between incident light and isolation of scattered wavelengths in generating a molecular fingerprint. It has a broad array of potential scientific applications, encompassing areas as diverse as food science and forensics. However, it may also be highly useful in clinical oncology. A recent focus of research in oncology has been in achieving the individualisation of care. Two important strategies to achieve a so-called “precision oncology” approach may include the detection of circulating tumour DNA (ctDNA) in more objectively evaluating treatment response and guiding de-escalation and intensification approaches in systemic therapy and therapeutic drug monitoring (TDM). Therapeutic drug monitoring involves the quantitation of plasma drug levels in order to tailor medication dosing in optimizing outcomes. The existing approaches to characterize small molecules, such as fluorescence-based and chromatographic strategies, may be limited by high costs, long turnaround times, and bulky equipment. Surface-enhanced Raman spectroscopy (SERS) may be deployed by utilizing a handheld device, with the potential for point of care, rapid turnaround, low-cost assessment of clinically relevant parameters, and prompt implementation of attendant changes in treatment. Although there is a growing body of data supporting the implementation of TDM and evaluation of ctDNA in achieving precision medicine, the uptake of such approaches remains relatively limited outside of clinical trials. As stated, the nature of existing analytical methodologies may prove to be a significant barrier to the routine clinic-based implementation of such approaches. Therefore, we provide the existing evidence for SERS in alleviating these barriers. We also provide insights into how SERS could contribute to clinical oncology. Full article
(This article belongs to the Special Issue The Evolving Landscape of Contemporary Cancer Therapies)
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