How to Prevent Obesity and Inflammatory Disease 2025

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Guest Editor
Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche, Università degli Studi di Palermo, 90133 Palermo, Italy
Interests: human nutrition; micronutrients; biofortified food; physical activity; gut peptides; bone remodeling and metabolism; glucose homeostasis; lipid homeostasis; systemic homeostasis; human physiology
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Special Issue Information

Dear Colleagues,

Obesity's complex inflammatory landscape requires a multidisciplinary approach. This Special Issue seeks to publish cutting-edge original research and insightful reviews that explore the cellular and systemic mechanisms by which lifestyle, dietary modifications, and mindset interventions can prevent or treat obesity-related inflammatory diseases. We welcome contributions that illuminate the intricate crosstalk between diverse physiological systems, including the gastrointestinal tract, brain, liver, adipose tissue, and bone.  

Dr. Sara Baldassano
Guest Editor

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Keywords

  • gastrointestinal tract
  • central nervous system
  • physical activity
  • bone
  • adipose tissue
  • insulin
  • liver
  • mental health
  • eating disorders
  • muscle
  • endocrine system
  • lifestyle intervention

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Published Papers (1 paper)

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Research

13 pages, 1381 KB  
Article
Anti-Inflammatory Effects of L-Fucose in 3T3-L1 Adipocytes
by Tomoya Nakamura, Tomohiko Nakao, Kazuyuki Ohara, Yuri Kominami, Miho Ito, Kazuki Mochizuki, Teruki Aizawa, Yusuke Akahori, Tomoya Ueno and Hideki Ushio
Obesities 2025, 5(4), 74; https://doi.org/10.3390/obesities5040074 - 11 Oct 2025
Viewed by 231
Abstract
L-fucose is a monosaccharide derived from brown algae and has potential applications as a functional food ingredient. Previous studies have reported that L-fucose reduces lipid accumulation in murine adipose tissue. Adipose tissue not only regulates energy metabolism but also functions as an endocrine [...] Read more.
L-fucose is a monosaccharide derived from brown algae and has potential applications as a functional food ingredient. Previous studies have reported that L-fucose reduces lipid accumulation in murine adipose tissue. Adipose tissue not only regulates energy metabolism but also functions as an endocrine organ involved in inflammation through the production and secretion of various adipokines. L-fucose is expected to exert anti-inflammatory effects and modulate adipokine secretion in adipocytes. In the present study, we investigated the anti-inflammatory effects of L-fucose in adipocytes. L-fucose significantly suppressed the expression of pro-inflammatory mediators and reduced the production of reactive oxygen species induced by inflammatory stimulation with a combination of lipopolysaccharide (LPS), tumor necrosis factor-⍺ (TNF-⍺), and interferon-γ (IFN-γ). These effects are likely mediated through the inhibition of key signaling pathways, including mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) pathways. Additionally, we found that L-fucose promoted the multimerization and secretion of high molecular weight (HMW) adiponectin, even under inflammatory conditions. Our results suggest that although L-fucose downregulates adiponectin expression, it contributes to the formation and/or stabilization of HMW adiponectin, which is functionally more relevant in anti-inflammatory and metabolic regulation. L-fucose thus holds promise as a functional food ingredient for mitigating inflammation in adipocytes. Full article
(This article belongs to the Special Issue How to Prevent Obesity and Inflammatory Disease 2025)
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