Special Issue "Renal Nutrition and Metabolism"
Deadline for manuscript submissions: 30 November 2020.
Interests: chronic kidney disease; renal transplantation; nutrition; low protein diet; micronutrients
Medical literature offers strong evidence that dietary habits are associated with the development and possibly the progression of chronic kidney disease (CKD). Therefore, the guidelines of many scientific societies suggest prescribing a low-protein diet to avoid the metabolic consequences of advanced CKD and to slow its progression to end-stage renal disease.
However, there are still some uncertainties regarding the stage of CKD at which starting to restrict protein consumption and whether it is worth-prescribing a progressive restriction that parallels the reduction of the glomerular filtration rate.
Consequently, there are no clear indications about the degree of restriction to adopt in the various stages of CKD (low- vs very-low-protein diet) as well as about possible differences in the quality of protein intake (vegetal or animal origin).
Furthermore, although a hypoproteic diet should not be prescribed in malnourished individuals, there is a substantial lack of information regarding the effect of protein restriction with respect to the onset of malnutrition and sarcopenia in selected categories of patients at risk of malnutrition (i.e., older and frailer individuals). In fact, these individuals have been excluded by most interventional and observational trials. However, since the frail phenotype is present in almost half of elderly CKD patients, the indication for an appropriate dietary prescription in this cohort is a matter of utmost importance.
Another topic that deserves to be explored is the lack of a unanimous definition of malnutrition in the CKD population. In fact, the coexistence of different definitions and clinical scores, validated for the different stages of CKD, is preventing the collection of accurate information on the epidemiology of this phenomenon and generates confusion respect to the nutritional outcomes of patients enrolled in clinical and observational trials.
Another source of confusion derives from the numerous areas of overlap between the current definitions of sarcopenia, malnutrition, and protein-energy wasting syndrome among CKD patients. Although the guidelines strongly indicate to prescribe a low-protein diet in well-nourished patients with advanced CKD, the same guidelines give limited relevance to the intake of the various micronutrients. In fact, although they report the suggested daily intake of microelements, there are no indications about the opportunity of their periodical monitoring and about the necessity of supplementing these nutrients at the different stages of CKD.
Finally, there are a number of unanswered issues in the field of dietary prescription in renal transplanted patients. In fact, it would be very relevant to have an accurate estimation of their nutritional status as well as to explore which nutritional intervention could help to maintain an optimal nutritional status and possibly to prevent or delay the metabolic complications of immunosuppressive therapy.
This Special Issue of Nutrients will address topics, including those mentioned here, that are of the utmost relevance for nutritional evaluation and dietary prescription in patients with various stages of CKD.
Prof. Piergiorgio Messa
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Chronic kidney disease
- Renal transplantation
- Low-protein diet
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Plant-Dominant Low-Protein Diet for Conservative Management of Chronic Kidney Disease
Professor Kamyar Kalantar-Zadeh
University of California Irvine (UCI), Department of Medicine, Division of Nephrology Hypertension and Kidney Transplantation, Orange, CA, USA