Submit to Nutrients Review for Nutrients Propose a Special Issue

Journal Browser

► Journal Browser

Challenges of Milk, Egg and Food Allergy in Early Age

Print Special Issue Flyer
Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: closed (20 May 2023) | Viewed by 8924

Share This Special Issue

Special Issue Editors

Prof. Dr. Antonella Muraro

E-Mail Website
Guest Editor

Food Allergy Referral Centre, Padua University Hospital, 35128 Padua, Italy
Interests: food allergy; food immunotherapy; anaphyaxis; atopic dermatitis; allergies in pediatric age
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Giovanni Battista Pajno

*
E-Mail Website
Guest Editor

Dept Human Pathol Adulthood & Childhood, University of Messina, Messina, Italy
Interests: Immunotherapy; food allergies; oral immunotherapy; allergic diseases; asthma; allergic rhinitis; atopic dermatitis; allergies in pediatric age
* Unexpectedly passed away on 11 April 2022

Dr. Cesar Martin Bozzola

E-Mail Website
Guest Editor

Department of Pediatrics, British Hospital-Perdriel, Buenos Aires, Argentina
Interests: allergy; clinical immunology; food allergy; drug allergy; rhinitis; asthma; atopic dermatitis; cows milk allergy; administration in allergy and clinical immunology; primary immunodeficiencies; secondary immunodeficiencies

Special Issue Information

Dear Colleagues,

Food allergy (FA) is a significant health issue that affects up to 6–8% of children worldwide. It presents as a heterogeneous clinical spectrum, ranging from mild reactions to severe anaphylaxis, and is often burdened by a significant reduction in the quality of life of both children and their parents. Historically, food allergy has often been characterized by presentation in the early stages of atopic march and the achievement of spontaneous tolerance by early school age for food allergens such as cow's milk and hen’s eggs. However, in some cases, food allergy persists over time, leading to an increased risk of life-threatening reactions. Aside from the traditional approach, which involves avoiding the offending foods, a novel paradigm shift is currently under way, with the spread of oral tolerance induction as a concept in allergy therapy. Thus, in recent years, the dietary management of allergic diseases has shifted from a passive approach, consisting of an elimination diet to relieve symptoms, to a “proactive” approach, introducing the possibility of also actively modulating the immune system by dietary interventions. The objective of this proposed Special Issue on “Challenges of Milk, Egg and Food Allergy in Early Age Heath” is to publish an overview of the current body of evidence on the latest nutritional epidemiological, pathogenetic, and diagnostic findings on food allergies, and the role of nutrition in this disease, particularly in early age children

Prof. Dr. Antonella Muraro
Prof. Dr. Giovanni Battista Pajno
Dr. Cesar Martin Bozzola
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

milk allergy
egg allergy
food allergy
diagnosis
oral immunotherapy
nutrition and diet intervention
food choice
quality of early life

Published Papers (4 papers)

Download All Papers

Research

Jump to: Review

13 pages, 770 KiB

Open AccessArticle

Assessment of Selected Intestinal Permeability Markers in Children with Food Allergy Depending on the Type and Severity of Clinical Symptoms

by Monika Niewiem and Urszula Grzybowska-Chlebowczyk

Nutrients 2022, 14(20), 4385; https://doi.org/10.3390/nu14204385 - 19 Oct 2022

Cited by 3 | Viewed by 1513

Abstract

Background: Food allergy (FA) has a broad range of symptoms, and clinical manifestations may concern several reactions from one system or organ. Aim: The aim of the study was to assess intestinal permeability (IP) based on the analysis of serum zonulin and bacterial lipopolysaccharides (LPS) levels in children with FA, taking into account the pathomechanism of immune reaction, clinical symptoms of FA and their severity. Material and methods: The study comprised 103 patients aged 7–60 months (median 34); 49 children with IgE-mediated allergy and 25 children with non-IgE-mediated allergy; the reference group comprised 29 children with functional gastrointestinal disorders. IP markers were determined using ELISA. Results: There was no correlation between the severity of clinical symptoms and the level of IP markers in children with FA. Zonulin and LPS levels were significantly higher in children with FA and gastrointestinal symptoms. Zonulin levels in the subgroup of children with non-IgE-mediated FA and gastrointestinal symptoms were significantly higher than in the subgroup of children with IgE-mediated FA and these symptoms. The level of LPS was significantly higher in the subgroup with IgE-mediated FA and atopic dermatitis. Conclusions: Zonulin and LPS levels were significantly higher in children with FA compared to children from the reference group. Zonulin levels were significantly higher in children with non-IgE-mediated FA than in children with IgE-mediated FA. Full article

(This article belongs to the Special Issue Challenges of Milk, Egg and Food Allergy in Early Age)

► Show Figures

Figure 1

11 pages, 845 KiB

Open AccessArticle

Prevalence of Food Allergy in France up to 5.5 Years of Age: Results from the ELFE Cohort

by Sarah Tamazouzt, Karine Adel-Patient, Antoine Deschildre, Caroline Roduit, Marie Aline Charles, Blandine de Lauzon-Guillain and Amandine Divaret-Chauveau

Nutrients 2022, 14(17), 3624; https://doi.org/10.3390/nu14173624 - 02 Sep 2022

Cited by 10 | Viewed by 2131

Abstract

Background: In France, updated data on food allergies (FAs) are lacking, despite the need for efficient FA management and prevention. This study aimed to evaluate the prevalence of FAs in children in France, describe the most common allergens and determine the prevalence of atopic diseases in children with FAs. Methods: The ELFE study comprises a French nationwide birth cohort, including 18,329 children born in 2011. FAs were assessed by parental reports of food avoidance based on medical advice related to FAs, provided at 2 months and 2, 3.5 and 5.5 years of age. Data regarding FAs were available for 16,400 children. Data were weighted to account for selection and attrition bias. Results: From birth to 5.5 years of age, FAs were reported for 5.94% (95% CI: 5.54–6.34) children. Milk was the most common allergen, followed by egg, peanut, exotic fruits, tree nuts, gluten and fish. Among children with FAs, 20.5% had an allergy to at least two different groups of allergens; 71% reported eczema at least once before 5.5 years of age; 24.4% reported incidence of asthma; and 42.3% reported incidence of allergic rhinitis or conjunctivitis. Conclusion: In France, the prevalence of FAs in children up to 5.5 years of age is approximately 6%. It was demonstrated that 1 in 5 children with allergies had multiple FAs. Full article

(This article belongs to the Special Issue Challenges of Milk, Egg and Food Allergy in Early Age)

► Show Figures

Graphical abstract

Review

Jump to: Research

22 pages, 883 KiB

Open AccessReview

IgE-Mediated Shellfish Allergy in Children

by Mattia Giovannini, Burcin Beken, Betul Buyuktiryaki, Simona Barni, Giulia Liccioli, Lucrezia Sarti, Lorenzo Lodi, Matteo Pontone, Irene Bartha, Francesca Mori, Cansin Sackesen, George du Toit, Andreas L. Lopata and Antonella Muraro

Nutrients 2023, 15(12), 2714; https://doi.org/10.3390/nu15122714 - 11 Jun 2023

Cited by 6 | Viewed by 2568

Abstract

Shellfish, including various species of mollusks (e.g., mussels, clams, and oysters) and crustaceans (e.g., shrimp, prawn, lobster, and crab), have been a keystone of healthy dietary recommendations due to their valuable protein content. In parallel with their consumption, allergic reactions related to shellfish may be increasing. Adverse reactions to shellfish are classified into different groups: (1) Immunological reactions, including IgE and non-IgE allergic reactions; (2) non-immunological reactions, including toxic reactions and food intolerance. The IgE-mediated reactions occur within about two hours after ingestion of the shellfish and range from urticaria, angioedema, nausea, and vomiting to respiratory signs and symptoms such as bronchospasm, laryngeal oedema, and anaphylaxis. The most common allergenic proteins involved in IgE-mediated allergic reactions to shellfish include tropomyosin, arginine kinase, myosin light chain, sarcoplasmic calcium-binding protein, troponin c, and triosephosphate isomerase. Over the past decades, the knowledge gained on the identification of the molecular features of different shellfish allergens improved the diagnosis and the potential design of allergen immunotherapy for shellfish allergy. Unfortunately, immunotherapeutic studies and some diagnostic tools are still restricted in a research context and need to be validated before being implemented into clinical practice. However, they seem promising for improving management strategies for shellfish allergy. In this review, epidemiology, pathogenesis, clinical features, diagnosis, and management of shellfish allergies in children are presented. The cross-reactivity among different forms of shellfish and immunotherapeutic approaches, including unmodified allergens, hypoallergens, peptide-based, and DNA-based vaccines, are also addressed. Full article

(This article belongs to the Special Issue Challenges of Milk, Egg and Food Allergy in Early Age)

► Show Figures

Figure 1

15 pages, 401 KiB

Open AccessReview

Hidden and Rare Food Allergens in Pediatric Age

by Leonardo Tomei, Antonella Muraro, Mattia Giovannini, Simona Barni, Giulia Liccioli, Erika Paladini, Lucrezia Sarti, Benedetta Pessina, Isabel Skypala, Elio Novembre and Francesca Mori

Nutrients 2023, 15(6), 1386; https://doi.org/10.3390/nu15061386 - 13 Mar 2023

Cited by 1 | Viewed by 2126

Abstract

In food allergy management, the avoidance of the allergen that caused the reaction plays a fundamental role. Nevertheless, that can be thwarted in case of accidental exposure to a rare or hidden allergen, causing the adoption of a monotonous diet and a consequent reduction in the quality of life of the patient and their family. The identification of a rare and hidden allergen is an important diagnostic challenge, taking into account that a significant proportion of all food reactions is in reality due to them. The aim of the present review is to provide the pediatric allergist an overview of the possible sources of rare and hidden food allergens, taking into consideration the routes of exposure to these potential allergens with the main examples published in the scientific literature and the distinction between types of direct or cross-contamination. The identification of the allergen responsible for the reaction and the provision of a dietary advice customized for the specific individual’s dietary habits is essential to improve quality of life of the familiar nucleus and to reduce the risk of further allergic reactions. Full article

(This article belongs to the Special Issue Challenges of Milk, Egg and Food Allergy in Early Age)

► Show Figures