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Nutrients
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Epidemiological Study of Fatty Acids for Healthy Ageing
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Epidemiological Study of Fatty Acids for Healthy Ageing

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 8009

Special Issue Editor

Dr. Yasutake Tomata

E-Mail Website
Guest Editor
School of Nutrition and Dietetics, Faculty of Health and Social Services, Kanagawa University of Human Services, Yokosuka, Japan
Interests: epidemiology; nutrition; gerontology; healthy aging; diet
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

With the aging of the population in recent decades, promoting healthy aging is a great concern worldwide. As modifiable nutritional factors on healthy aging, fatty acids are examined. For example, n-3 and n-6 polyunsaturated fatty acids (PUFAs) are expected to serve as preventive factors that support healthy aging due to their multiple roles, such as reducing chronic inflammatory or oxidative stress, presenting neuroprotection or cardiovascular protection.

This Special Issue will feature articles regarding epidemiological studies (prospective studies, systematic reviews of prospective studies, or Mendelian randomization) on the impact of fatty acids on healthy aging. As these are the outcome about healthy aging, this Special Issue is also interested in functional disability, physical function, frailty, dementia, cognitive impairment, or survival without major chronic diseases.

Dr. Yasutake Tomata
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Fatty acid intake
  • Circulating fatty acids
  • Functional disability
  • Physical function
  • Frailty
  • Dementia
  • Cognitive impairment
  • Healthy aging

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Published Papers (2 papers)

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Research

9 pages, 272 KiB  
Article
Fatty Acids and Frailty: A Mendelian Randomization Study
by Yasutake Tomata, Yunzhang Wang, Sara Hägg and Juulia Jylhävä
Nutrients 2021, 13(10), 3539; https://doi.org/10.3390/nu13103539 - 9 Oct 2021
Cited by 13 | Viewed by 4591
Abstract
Background: Observational studies have suggested that fatty acids such as higher levels of n-3 polyunsaturated fatty acids (PUFAs) may prevent frailty. By using Mendelian randomization analysis, we examined the relationship between fatty acids and frailty. Methods: We used summary statistics data for single-nucleotide [...] Read more.
Background: Observational studies have suggested that fatty acids such as higher levels of n-3 polyunsaturated fatty acids (PUFAs) may prevent frailty. By using Mendelian randomization analysis, we examined the relationship between fatty acids and frailty. Methods: We used summary statistics data for single-nucleotide polymorphisms associated with plasma levels of saturated fatty acids (palmitic acid, stearic acid), mono-unsaturated fatty acids (MUFAs) (palmitoleic acid, oleic acid), n-6 PUFAs (linoleic acid, arachidonic acid), and n-3 PUFAs (alpha-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid), and the corresponding data for frailty index (FI) in 356,432 individuals in the UK Biobank. Results: Although there were no robust associations on the MUFAs or the PUFAs, genetically predicted higher plasma stearic acid level (one of saturated fatty acids) was statistically significantly associated with higher FI (β = 0.178; 95% confidence interval = −0.050 to 0.307; p = 0.007). Such a relationship was also observed in a multivariate MR (β = 0.361; 95% confidence interval = 0.155 to 0.567; p = 0.001). Genetically predicted higher palmitic acid was also significantly associated with higher FI (β = 0.288; 95% confidence interval = 0.128 to 0.447; p < 0.001) in the multivariate MR analysis. Conclusions: The present MR study implies that saturated fatty acids, especially stearic acid, is a risk factor of frailty. Full article
(This article belongs to the Special Issue Epidemiological Study of Fatty Acids for Healthy Ageing)
14 pages, 569 KiB  
Article
Low Circulating Concentrations of Very Long Chain Saturated Fatty Acids Are Associated with High Risk of Mortality in Kidney Transplant Recipients
by Fabian A. Vogelpohl, António W. Gomes-Neto, Ingrid A. Martini, Camilo G. Sotomayor, Dion Groothof, Maryse C. J. Osté, Margaretha Rebecca Heiner-Fokkema, Frits A. J. Muskiet, Stefan P. Berger, Gerjan Navis, Ido P. Kema and Stephan J. L. Bakker
Nutrients 2021, 13(10), 3383; https://doi.org/10.3390/nu13103383 - 26 Sep 2021
Cited by 1 | Viewed by 2629
Abstract
Kidney transplant recipients (KTR) are at increased risk of mortality, particularly from infectious diseases, due to lifelong immunosuppression. Although very long chain saturated fatty acids (VLSFA) have been identified as crucial for phagocytosis and clearance of infections, their association with mortality in immunocompromised [...] Read more.
Kidney transplant recipients (KTR) are at increased risk of mortality, particularly from infectious diseases, due to lifelong immunosuppression. Although very long chain saturated fatty acids (VLSFA) have been identified as crucial for phagocytosis and clearance of infections, their association with mortality in immunocompromised patient groups has not been studied. In this prospective cohort study we included 680 outpatient KTR with a functional graft ≥1 year and 193 healthy controls. Plasma VLSFA (arachidonic acid (C20:0), behenic acid (C22:0) and lignoceric acid (C24:0)) were measured by gas chromatography coupled with a flame ionization detector. Cox regression analyses was used to prospectively study the associations of VLSFA with all-cause and cause-specific mortality. All studied VLSFA were significantly lower in KTR compared to healthy controls (all p < 0.001). During a median (interquartile range) follow-up of 5.6 (5.2–6.3) years, 146 (21%) KTR died, of which 41 (28%) died due to infectious diseases. In KTR, C22:0 was inversely associated with risk of all-cause mortality, with a HR (95% CI) per 1-SD-increment of 0.79 (0.64–0.99), independent of adjustment for potential confounders. All studied VLSFA were particularly strongly associated with mortality from infectious causes, with respective HRs for C20:0, C22:0 and C24:0 of 0.53 (0.35–0.82), 0.48 (0.30–0.75), and 0.51 (0.33–0.80), independent of potential confounders. VLSFA are inversely associated with infectious disease mortality in KTR after adjustment, including HDL-cholesterol. Further studies are needed to assess the effect of VLSFA-containing foods on the risk of infectious diseases in immunocompromised patient groups. Full article
(This article belongs to the Special Issue Epidemiological Study of Fatty Acids for Healthy Ageing)
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