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Nutrients
Special Issues
Mechanisms of Beneficial Action of Phytochemicals in Alzheimer’s Disease
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Mechanisms of Beneficial Action of Phytochemicals in Alzheimer’s Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 1349

Special Issue Editor

Prof. Dr. Akira Nakajima

E-Mail Website
Guest Editor
Applied Biology and Food Sciences, Faculty of Agriculture and Life Science, Hirosaki University, 3 Bunkyo-cho, Hirosaki, Aomori 036-8561, Japan
Interests: Alzheimer's disease; aging; memory; behavior; polyphenols

Special Issue Information

Dear Colleagues,

Alzheimer’s disease (AD), which is characterized by the presence of amyloid plaques and neurofibrillary tangles accompanied by neurodegeneration, is the most common form of dementia among the elderly. It is widely accepted that phytochemicals exert a wide range of beneficial effects against the pathological features of AD, such as amyloid beta pathology, hyperphosphorylation of tau, and oxidative stress. The objective of this Special Issue is to collect recent findings regarding the mechanisms of beneficial action of phytochemicals and phytochemical-rich plant extracts against AD. We encourage the submission of original research studies in in vitro cell culture models and in vivo animal models of AD. Review articles are also welcome.

Prof. Dr. Akira Nakajima
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Alzheimer’s disease
  • amyloid beta
  • phytochemicals
  • hyperphosphorylation of tau
  • oxidative stress
  • neuroinflammation
  • neurodegeneration
  • memory impairment

Published Papers (1 paper)

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Research

13 pages, 2064 KiB  
Article
Apple Pomace Extract Improves MK-801-Induced Memory Impairment in Mice
by Ayako Watanabe, Minori Shimada, Hayato Maeda, Tsuyoshi Narumi, Junji Ichita, Koh Itoku and Akira Nakajima
Nutrients 2024, 16(2), 194; https://doi.org/10.3390/nu16020194 - 6 Jan 2024
Viewed by 1142
Abstract
Alzheimer’s disease (AD) is a neurodegenerative disease that involves progressive cognitive decline accompanied by synaptic degeneration and impaired neurotransmission. Recent studies revealed that apple pomace, a waste byproduct of the apple processing industry, has beneficial health properties, but its potential to prevent and [...] Read more.
Alzheimer’s disease (AD) is a neurodegenerative disease that involves progressive cognitive decline accompanied by synaptic degeneration and impaired neurotransmission. Recent studies revealed that apple pomace, a waste byproduct of the apple processing industry, has beneficial health properties, but its potential to prevent and treat AD has not been determined. Herein, we examined the effects of apple pomace extract on N-methyl-D-aspartate receptor antagonist MK-801-induced memory impairment in mice. Repeated treatment with apple pomace extract for 7 days reversed the MK-801-induced impairment of associative memory and recognition memory. RNA sequencing revealed that repeated treatment with apple pomace extract altered the gene expression profile in the hippocampus of mice. Real-time PCR showed that apple pomace extract induced upregulation of the mRNA expression for Zfp125 and Gstp1. Furthermore, gene sets related to synapse and neurotransmission were upregulated by apple pomace extract. These findings indicate that apple pomace extract may be useful for the prevention and treatment of AD. Full article
(This article belongs to the Special Issue Mechanisms of Beneficial Action of Phytochemicals in Alzheimer’s Disease)
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