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Nutrients
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Pediatric Diabetes, Obesity and Metabolic Health: The Role of Nutrition...
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Pediatric Diabetes, Obesity and Metabolic Health: The Role of Nutrition and Beyond

A Special Issue of Nutrients (ISSN 2072-6643) belonging to the section "Pediatric Nutrition".

Deadline for manuscript submissions: 25 December 2026 | Viewed by 882

Editors

Dr. Tatjana Ábel

E-Mail Website
Guest Editor
Department of Dietetics and Nutritional Sciences, Faculty of Health Sciences, Semmelweis University, 1088 Budapest, Hungary
Interests: diet; type 2 diabetes mellitus; hyperlipidemia; cardiovascular disease; MASLD
Dr. Péter Tõth-Heyn

E-Mail Website
Guest Editor
Pediatric Center, Semmelweis University, 1083 Budapest, Hungary
Interests: type 1 diabetes mellitus; technology; AID; diabetic ketoacidosis

Special Issue Information

Dear Colleagues,

The rising prevalence of pediatric diabetes, obesity, and related metabolic disorders represents a major global health challenge. This Special Issue aims to provide a comprehensive overview of the current advances in prevention, pathophysiology, and management, with a particular focus on the role of nutrition alongside emerging therapeutic strategies.

Nutritional factors play a central role in both the development and treatment of metabolic diseases in children. At the same time, technological innovations—such as automated insulin delivery (AID) systems—are transforming diabetes care, enabling improved glycemic outcomes and more flexible dietary patterns. Understanding how nutrition interacts with these novel therapies is essential for optimizing individualized treatment approaches.

We invite the submission of original research, reviews, and clinical studies addressing pediatric diabetes (type 1 and type 2), obesity, insulin resistance, metabolic syndrome, and related conditions. Topics of interest include dietary interventions, early-life nutrition, behavioral and environmental influences, digital health solutions, and multidisciplinary care models.

With this Special Issue, we aim to advance the current knowledge and support evidence-based strategies to improve metabolic health in children and adolescents.

Dr. Tatjana Ábel
Dr. Péter Tõth-Heyn
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • type 1 diabetes
  • type 2 diabetes
  • childhood obesity
  • metabolic health
  • nutrition
  • dietary interventions
  • automated insulin delivery (AID)
  • glycemic control
  • insulin resistance
  • pediatric endocrinology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

15 pages, 493 KB  
Article
Neonatal Total Parenteral Nutrition and Long-Term Metabolic Outcomes: An 18-Year Nationwide Cohort Study of 2.3 Million Infants
by Tak Kyu Oh and In-Ae Song
Nutrients 2026, 18(15), 2406; https://doi.org/10.3390/nu18152406 - 23 Jul 2026
Viewed by 533
Abstract
Background/Objectives: Total parenteral nutrition (TPN) is essential for neonates unable to receive adequate enteral feeding, but its long-term metabolic effects remain uncertain. This study evaluated associations between neonatal TPN exposure, exposure duration, and later endocrinologic or metabolic disorders. Methods: This nationwide [...] Read more.
Background/Objectives: Total parenteral nutrition (TPN) is essential for neonates unable to receive adequate enteral feeding, but its long-term metabolic effects remain uncertain. This study evaluated associations between neonatal TPN exposure, exposure duration, and later endocrinologic or metabolic disorders. Methods: This nationwide cohort included 2,424,716 infants born in South Korea between 2005 and 2010. TPN exposure was identified during the first 28 days of life. The primary outcome was the first occurrence of type 2 diabetes mellitus (T2DM), essential hypertension, dyslipidemia, or obesity during follow-up of up to 18 years. The primary analysis used inverse probability of treatment-weighted (IPTW) Cox models, whereas duration-based associations were evaluated using secondary exploratory multivariable Cox regression. Results: The final cohort included 2,303,567 infants, of whom 7656 received TPN. In the primary IPTW analysis, any neonatal TPN exposure was not associated with either the primary composite outcome (HR 1.01, 95% CI 0.94–1.09; p = 0.801) or T2DM (HR 1.12, 95% CI 0.93–1.35; p = 0.215). In secondary exploratory multivariable analyses, TPN exposure for ≥3 days was associated with T2DM (adjusted HR 2.14, 95% CI 1.34–3.41; p = 0.001), whereas exposure for 1–2 days was not. Conclusions: The primary IPTW analysis showed no significant association between any neonatal TPN exposure and the primary composite outcome or T2DM. The association observed for ≥3 days in secondary exploratory analyses should be regarded as hypothesis-generating. Full article
(This article belongs to the Special Issue Pediatric Diabetes, Obesity and Metabolic Health: The Role of Nutrition and Beyond)
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