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Nutrition Management for Pediatric Gastrointestinal Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Pediatric Nutrition".

Deadline for manuscript submissions: 5 August 2025 | Viewed by 2160

Special Issue Editor


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Guest Editor
1. Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, FL 33602, USA
2. Pediatric Gastroenterology, Hepatology, and Nutrition of Florida, St. Petersburg, FL 33701, USA
Interests: pediatric gastroenterology; allergic disease; infant nutrition; eosinophilic gastrointestinal disorders; nutritional interventions; clinical nutrition; pediatric endoscopy

Special Issue Information

Dear Colleagues,

Pediatric gastrointestinal (GI) diseases pose unique nutritional challenges, requiring tailored approaches to support optimal growth, development, and quality of life. The Special Issue “Nutrition Management for Pediatric Gastrointestinal Disease” will address these challenges through cutting-edge research, clinical insights, and practical strategies.

Children with GI disorders, including inflammatory bowel disease (IBD), celiac disease, gastroesophageal reflux disease (GERD), eosinophilic disorders (EGIDs), and functional gastrointestinal disorders, face significant nutritional hurdles. These conditions disrupt digestion and absorption, necessitating specialized dietary interventions to manage symptoms, prevent malnutrition, and ensure adequate nutrient intake. For those with eosinophilic GI disorders, dietary modification and allergen avoidance are especially critical.

This Special Issue aims to provide a comprehensive overview of current practices and emerging research in pediatric GI nutrition. By integrating diverse perspectives and recent advancements, we seek to enhance understanding and improve clinical practices, ultimately contributing to better health outcomes and quality of life for affected children.

Dr. Michael John Wilsey
Guest Editor

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pediatric gastrointestinal diseases
  • nutritional management
  • inflammatory bowel disease (IBD)
  • celiac disease
  • gastroesophageal reflux disease (GERD)
  • eosinophilic gastrointestinal disorders (EGIDs)
  • dietary interventions
  • nutrient absorption
  • allergen avoidance
  • pediatric nutrition

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Published Papers (2 papers)

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Research

9 pages, 1022 KiB  
Article
Infant Colic Symptoms and Amino Acid Formula: Insights from a Prospective Cohort Study
by Jerry M. Brown, Jessica V. Baran, Luke Lamos, Jesse Beacker, Jared Florio, Lea V. Oliveros, Abigail L. Fabbrini, Andrew A. Farrar and Michael J. Wilsey
Nutrients 2025, 17(8), 1302; https://doi.org/10.3390/nu17081302 - 9 Apr 2025
Viewed by 535
Abstract
Background/Objectives: Infant functional disorders, including colic, irritability, and sleep disturbances, often overlap with symptoms of cow’s milk protein allergy (CMPA). While extensively hydrolyzed formulas are commonly used to address these issues, the short-term efficacy of amino acid formulas (AAF) for managing colic remains [...] Read more.
Background/Objectives: Infant functional disorders, including colic, irritability, and sleep disturbances, often overlap with symptoms of cow’s milk protein allergy (CMPA). While extensively hydrolyzed formulas are commonly used to address these issues, the short-term efficacy of amino acid formulas (AAF) for managing colic remains understudied. This secondary analysis of a previously published prospective cohort, the largest of its kind in the United States, evaluated the short-term impact of AAF in improving colic and associated symptoms in infants under six months of age with suspected CMPA. Methods: This real-world prospective cohort study analyzed data from 138 infants with suspected CMPA initiated on AAF at Visit 1. After excluding 34 infants due to incomplete data or treatment changes, 104 infants were included in the final analysis. Symptom severity and resolution were assessed through outcomes across two visits, with care provided by general pediatricians (82%) and pediatric gastroenterologists (18%). Results: At baseline, the most common symptoms were colic (n = 83), gassiness (n = 72), fussiness (n = 66), and sleep disturbances (n = 58). By the next follow-up visit (Visit 2), parents reported symptom improvements in colic (94%), gassiness (81%), fussiness (83%), and sleep disturbances (86%). Complete symptom resolution was observed in 73% of infants with colic, 68% with gassiness, 65% with fussiness, and 81% with sleep difficulties. By Visit 2, no infants had severe symptoms, with only mild residual symptoms reported. Conclusions: AAF was associated with significant short-term improvements in colic and related symptoms in infants with suspected CMPA. These preliminary findings highlight AAF as a promising dietary intervention during early infancy. Larger controlled studies are necessary to confirm these results and explore long-term outcomes. Full article
(This article belongs to the Special Issue Nutrition Management for Pediatric Gastrointestinal Disease)
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12 pages, 306 KiB  
Article
Dietary Challenges in Children with Gluten-Related Disorders: A Study on Food Neophobia
by Julyana Nogueira Firme, Emanuele Batistela dos Santos, Renata Puppin Zandonadi, Eduardo Yoshio Nakano and Raquel Braz Assunção Botelho
Nutrients 2024, 16(22), 3924; https://doi.org/10.3390/nu16223924 - 17 Nov 2024
Cited by 3 | Viewed by 1247
Abstract
Background/Objectives: Food neophobia (FN) in childhood is characterized by resistance to new foods, potentially impairing health and diet quality and impacting physical and mental development. Adequate nutrition in early childhood is crucial to preventing future problems. FN demands special attention, especially in cases [...] Read more.
Background/Objectives: Food neophobia (FN) in childhood is characterized by resistance to new foods, potentially impairing health and diet quality and impacting physical and mental development. Adequate nutrition in early childhood is crucial to preventing future problems. FN demands special attention, especially in cases of gluten-related disorders (GRD), due to the risks associated with restrictive diets and food allergies. The objective of this study was to investigate and classify the prevalence of FN among Brazilian children aged 4 to 11 years with GRD. Methods: For this cross-sectional study, a questionnaire validated in Portuguese, with 25 items, assessed FN in three domains: general FN, FN of fruits, and FN of vegetables. Data were collected via Google Forms. Results: Of 209 children with GRD, the majority were female, 83.7% were diagnosed with celiac conditions, 81.3% followed a diet, and 43.1% had moderate total food neophobia. Brazilian children with GRD have a moderate prevalence of food neophobia. General and vegetable neophobia predominate, while fruit FN is lower. Girls exhibit greater neophobia towards vegetables. Conclusions: Neophobia does not vary with age, suggesting the persistence of the behavior and potential nutritional challenges in adult life. Differentiated attention to this population is essential to minimize long-term impacts. Full article
(This article belongs to the Special Issue Nutrition Management for Pediatric Gastrointestinal Disease)
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