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Nutrients
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Nutritional Monitoring and Intervention in Inflammatory Bowel Diseases
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Nutritional Monitoring and Intervention in Inflammatory Bowel Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 25 June 2026 | Viewed by 1666

Special Issue Editor

Prof. Dr. Paolo Gionchetti

E-Mail Website
Guest Editor
1. Department of Medical and Surgical and Sciences, University of Bologna, 40138 Bologna, Italy
2. IBD Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy
Interests: inflammatory bowel disease; Crohn’s disease; ulcerative colitis; nutrition; diagnosis; nutrition management
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Diet plays a central role in the pathogenesis, clinical course, and management of Inflammatory Bowel Diseases (IBD), including Crohn’s disease and ulcerative colitis. Over recent years, increasing evidence has highlighted how specific dietary components and patterns can influence intestinal inflammation, microbiota composition, and therapeutic response. Nutritional management has therefore emerged as a cornerstone in both the prevention of disease relapse and the improvement of patients’ quality of life.

We are pleased to invite you to submit your research to this Special Issue of Nutrients, which aims to provide an updated and multidisciplinary perspective on the interaction between diet, nutrition, and IBD pathophysiology.

In this Special Issue, we welcome original research articles and reviews. Research areas may include (but are not limited to) the following: dietary interventions, exclusion and enteral diets, nutritional deficiencies, microbiota modulation, personalized nutrition, nutraceuticals and innovative digital tools for dietary monitoring in IBD.

We look forward to receiving your valuable contributions.

Prof. Dr. Paolo Gionchetti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammatory bowel disease
  • Crohn’s disease
  • ulcerative colitis
  • nutrition
  • dietary intervention
  • microbiota
  • malnutrition
  • nutraceuticals
  • enteral nutrition

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Published Papers (2 papers)

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Research

17 pages, 1014 KB  
Article
Long-Term Outcomes of Mediterranean-Adapted Crohn’s Disease Exclusion Diet in Mild Pediatric Crohn’s Disease: A Real-Life Study from a Referral IBD Center
by Patrizia Alvisi, Maria Chiara Valerii, Enrico Perre, Gilda Barbieri, Fernando Rizzello, Marco Congiu, Arianna Pranzetti, Nikolas Kostantine Dussias, Francesca Sbravati, Veronica Imbesi, Enzo Spisni and Flavio Labriola
Nutrients 2026, 18(8), 1290; https://doi.org/10.3390/nu18081290 - 20 Apr 2026
Viewed by 646
Abstract
Background: Exclusive enteral nutrition (EEN) is the recommended first-line therapy for induction of remission in pediatric mild-to-moderate Crohn’s disease (CD), but its restrictive nature often limits adherence and long-term sustainability. A modified version of the Crohn’s Disease Exclusion Diet (CDED), integrating Mediterranean [...] Read more.
Background: Exclusive enteral nutrition (EEN) is the recommended first-line therapy for induction of remission in pediatric mild-to-moderate Crohn’s disease (CD), but its restrictive nature often limits adherence and long-term sustainability. A modified version of the Crohn’s Disease Exclusion Diet (CDED), integrating Mediterranean dietary principles, was developed to offer a more acceptable alternative while preserving therapeutic efficacy. Methods: We conducted a retrospective, single-center study comparing short- and long-term outcomes of a Mediterranean-adapted CDED (M-CDED) with partial enteral nutrition (PEN) versus standard EEN in children with mild-to-moderate CD. Clinical remission was assessed after 8 and 16 weeks, while long-term outcomes were assessed after 1 and 2 years. Results: Data collected from thirty-two patients were analyzed (EEN, 14; M-CDED, 18). Clinical remission rates were comparable after 8 weeks (92.8% EEN vs. 94.4% M-CDED) and 16 weeks (100% in both groups). However, at 12 and 24 months, M-CDED was associated with significantly higher rates of clinical and biochemical remission and a markedly lower need for biologic drugs (12-month biologic initiation: 50% EEN vs. 11.1% M-CDED; p = 0.01). Adherence to M-CDED was excellent throughout follow-up. Conclusions: M-CDED with PEN appears to be as effective as EEN for remission induction, with improved long-term disease control and reduced therapeutic escalation. These findings support the feasibility of M-CDED as a sustainable option for long-term management of pediatric CD. Prospective studies are needed to confirm these results. Full article
(This article belongs to the Special Issue Nutritional Monitoring and Intervention in Inflammatory Bowel Diseases)
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15 pages, 1045 KB  
Article
Optimizing Malnutrition Risk Detection in Inflammatory Bowel Disease: A Longitudinal Analysis of Serial Nutritional Screening Tools
by Agnese Favale, Valentina Orrù, Nicola Lutzu, Amalia Di Petrillo, Mauro Demurtas, Ivan Ibba, Angelo Italia, Massimo Claudio Fantini and Sara Onali
Nutrients 2026, 18(3), 383; https://doi.org/10.3390/nu18030383 - 24 Jan 2026
Cited by 1 | Viewed by 692
Abstract
Background: Malnutrition is frequently under-investigated during remission in patients with Inflammatory Bowel Disease (IBD), despite its significant impact on clinical outcomes and quality of life. This study aimed to evaluate the increase in diagnostic performance of five nutritional screening tools (NSTs) when serially [...] Read more.
Background: Malnutrition is frequently under-investigated during remission in patients with Inflammatory Bowel Disease (IBD), despite its significant impact on clinical outcomes and quality of life. This study aimed to evaluate the increase in diagnostic performance of five nutritional screening tools (NSTs) when serially administered to IBD outpatients in sustained clinical remission. Methods: In this prospective, single-center cohort study, NSTs were administered, and body composition analysis was performed in IBD patients at baseline and after six months. At both time points, the sensitivity, specificity, predictive values, and accuracy of NSTs in detecting malnutrition and persistent malnutrition per ESPEN and GLIM criteria were evaluated, comparing repeated to single-point assessments. A sensitivity analysis using low FFMI as a reference was also performed. Results: Sixty-six IBD patients (32 Crohn’s disease; 34 ulcerative colitis) were enrolled. At baseline, 25.7% and 9% of patients were malnourished according to ESPEN and GLIM criteria, respectively, with 7.5% exhibiting low FFMI. Malnutrition prevalence increased over time to 53%, 16.6%, and 16.6%, respectively. Among NSTs, MUST and SaskIBD-NR consistently exhibited the highest specificity for malnutrition detection at baseline, at 6 months, and for persistent malnutrition for ESPEN, GLIM and low FFMI. Serial (repeated) NST administration markedly improved the specificity of all tools, compared to single-point assessments. Conclusions: Serial nutritional screening with MUST or SaskIBD-NR significantly enhances the specificity of malnutrition risk detection in IBD patients in remission, supporting the incorporation of repeated nutritional assessments into clinical practice to offer a practical strategy to enhance screening effectiveness in IBD outpatient care. Full article
(This article belongs to the Special Issue Nutritional Monitoring and Intervention in Inflammatory Bowel Diseases)
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