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Special Issue "Nutrition and Supplements during Pregnancy (2nd Edition)"

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A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition in Women".

Deadline for manuscript submissions: 20 January 2024 | Viewed by 1944

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Special Issue Editor

Dr. Linglin Xie

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Guest Editor

Department of Nutrition, Texas A&M University, College Station, TX, USA
Interests: obesity; early-life nutrition; offspring obesity; maternal diet intervention; pregnancy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

During pregnancy, expectant mothers put more focus on their diet, aiming to improve their own health and promote fetus growth. However, the roles of critical nutrients in pregnancy and the available evidence on the use of supplements to reduce risks and improve maternal and fetal outcomes remain unclear. In addition, it is now well established that in utero and early life, exposure to under- or over-nutrition can disrupt normal growth and development and thus change the offspring phenotype to one that is prone to future diseases. There is an emerging need to understand how nutrition during the sensitive time periods of early developmental plasticity can impact offspring health.

Considering the success of the previous Special Issue entitled “Nutrition and Supplements during Pregnancy”, we are pleased to announce that we are launching a second Special Issue on this topic. The objective of this Special Issue titled “Nutrition and Supplements during Pregnancy (2nd Edition)” is to showcase the latest research focusing on topics among this non-comprehensive list:

Nutritional management in pregnancy including in a high-risk pregnancy;
Maternal food safety and offspring outcomes;
Safety and efficacy of supplements in pregnancy;
Maternal macro- and micronutrient intake and offspring obesity, metabolic syndrome, diabetes, etc.;
Early-life nutritioninterventions and long-term cardiometabolic outcomes;
Maternal nutrition intake, gut microflora changes, and consequences on health;

Molecular and epigenetic mechanisms underlying how maternal nutrition reprograms offspring health.

Dr. Linglin Xie
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

pregnancy
nutrition
supplement
developmental origins of health and disease (DOHaD)
perinatal metabolism and metabolomics
gut microbiota
epigenetic regulation
childhood obesity
diabetes
metabolic syndromes
food safety

Published Papers (3 papers)

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Research

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Open AccessArticle

Are Twin Pregnancies at Higher Risk for Iron and Calcium Deficiency than Singleton Pregnancies?

Anna Dera-Szymanowska

Dorota Filipowicz

Natalia Misan

Krzysztof Szymanowski

Thilo Samson Chillon

Sabrina Asaad

Qian Sun

Ewelina Szczepanek-Parulska

Lutz Schomburg

and

Marek Ruchała

Nutrients 2023, 15(18), 4047; https://doi.org/10.3390/nu15184047 - 18 Sep 2023

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Abstract

The aim of this study was to compare the iron and calcium status in singleton and twin pregnancies and to assess whether there is an increased risk for iron and calcium deficiency in twin gestation. The study included 105 singleton and 9 twin pregnancies at or above 35 weeks of gestation. Information on prenatal supplementation with iron or calcium was acquired, and adverse perinatal outcomes were recorded. Biosamples from all 114 mothers and 73 newborns (61 singleton and 12 twin newborns) were finally analyzed. Total iron and calcium concentrations in serum were measured through total reflection X-ray fluorescence analysis. The results indicated no significant differences in maternal serum iron and calcium concentrations between singleton and twin pregnancies. Similarly, iron and calcium concentrations in newborn umbilical cord serum samples were not different between singleton and twin pregnancies. The comparison of total iron and calcium between mothers and umbilical cord serum indicated significantly lower concentrations in the mothers, with the differences being not homogenous but rather pair-specific. A significant positive correlation between maternal serum and umbilical cord serum calcium concentration was noticed. Prenatal iron supplementation was associated with higher iron concentrations in both mothers and newborns, supporting the efficiency of supplementation and the quality of the study methods. Collectively, the data indicate no significant differences in serum iron and calcium concentrations with regard to singleton or twin pregnancies and the efficiency of iron supplementation during pregnancy for increasing iron status. Full article

(This article belongs to the Special Issue Nutrition and Supplements during Pregnancy (2nd Edition))

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Open AccessArticle

Association between Dietary Patterns and the Risk of Hyperemesis Gravidarum

and

Nutrients 2023, 15(15), 3300; https://doi.org/10.3390/nu15153300 - 25 Jul 2023

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Abstract

(1) Background: Although studies have suggested that dietary interventions may have potential benefits over conventional medical treatments, research on the association between dietary patterns and hyperemesis gravidarum (HG) in pregnant women is scarce. (2) Methods: To explore the relationship between dietary patterns and the risk of HG, a cross-sectional study was conducted in Xi’an, China from April 2021 to September 2022. Dietary intake was assessed by a semi-quantitative food-frequency questionnaire, and then factor analysis was used to derive dietary patterns. HG was defined as persistent and severe nausea and vomiting with weight loss ≥ 5%, pregnancy-unique quantification of emesis (PUQE) score ≥ 13, or hospitalization due to vomiting. Logistic regression models were used to estimate ORs and 95% CIs for HG according to dietary pattern scores. Stratified analyses and tests for interaction were performed by potential confounders. (3) Results: Of the 3122 pregnant women enrolled, 2515 individuals (mean age: 31.2 ± 3.4 years) were included in the final analysis. In total, 226 (8.9%) pregnant women were identified as having HG. Five dietary patterns were identified. After adjusting for covariates, the highest quartile of the “fish, shrimp and meat” and “egg, milk and water drinking” patterns was associated with a 37% and 58% lower risk of HG compared with the lowest quartile, respectively (p-trend < 0.05). Conversely, the highest quartile of the “beverage” pattern was associated with a 64% higher risk of HG compared with the lowest quartile (p-trend = 0.02). Furthermore, significant interactions were observed between the “egg, milk and water drinking” pattern and parity, employment status and nutritional supplement use (p-interaction < 0.05). (4) Conclusions: A diet rich in eggs, milk, seafood and unprocessed poultry and animal meat may be a protective factor against HG, while a diet high in beverages may be detrimental to HG. These associations may vary by parity, employment status and nutritional supplement use. Full article

(This article belongs to the Special Issue Nutrition and Supplements during Pregnancy (2nd Edition))

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Review

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Open AccessReview

Trophoblast Differentiation: Mechanisms and Implications for Pregnancy Complications

and

Nutrients 2023, 15(16), 3564; https://doi.org/10.3390/nu15163564 - 12 Aug 2023

Viewed by 696

Abstract

Placental development is a tightly controlled event, in which cell expansion from the trophectoderm occurs in a spatiotemporal manner. Proper trophoblast differentiation is crucial to the vitality of this gestational organ. Obstructions to its development can lead to pregnancy complications, such as preeclampsia, fetal growth restriction, and preterm birth, posing severe health risks to both the mother and offspring. Currently, the only known treatment strategy for these complications is delivery, making it an important area of research. The aim of this review was to summarize the known information on the development and mechanistic regulation of trophoblast differentiation and highlight the similarities in these processes between the human and mouse placenta. Additionally, the known biomarkers for each cell type were compiled to aid in the analysis of sequencing technologies. Full article

(This article belongs to the Special Issue Nutrition and Supplements during Pregnancy (2nd Edition))

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