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Nutrients
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Metabolic Diseases and Lipid Metabolism Regulators
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Metabolic Diseases and Lipid Metabolism Regulators

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (30 August 2023) | Viewed by 3706

Special Issue Editor

Dr. Zhen Chen

E-Mail Website
Guest Editor
School of Pharmacy, Jiangsu University, Zhenjiang 212013, China
Interests: functional foods; food chemistry; lipid metabolism; oxidative stress; antioxidation; lipid analysis; lipidomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I am pleased to announce the launch of the Special Issue of Nutrients entitled “Metabolic Diseases and Lipid Metabolism Regulators”. Metabolic diseases, disrupting normal metabolism, have become one of the most common public health issues worldwide and are closely related to the dysregulation of lipid metabolism. Consequently, researchers have searched for nutraceuticals that regulate lipid metabolism and their potential to prevent metabolic diseases for years. Significant progress has been made in the development of functional foods, the evaluation of nutrient bioactivity, the search for dietary sources, the elucidation of lipid regulation at the molecular level, and other related investigations. This Special Issue aims to present advanced research on newly found nutraceuticals against metabolic diseases, including liver diseases, kidney diseases, obesity, cardiovascular diseases, diabetes, and other disorders. In addition, this Special Issue will bring together the latest research on nutrient analysis, metabolomics, mechanism or pathway studies, dietary habit investigation, cohort studies, and health management with regard to lipid regulation nutrients. In this Special Issue, original research articles and reviews are welcome. We look forward to receiving your contributions.

Dr. Zhen Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic syndrome
  • hypolipidemia
  • mitochondrial function
  • non-alcoholic fatty liver disease
  • functional food
  • bioactive component in diet
  • metabolomics

Published Papers (3 papers)

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Research

13 pages, 1540 KiB  
Article
A Cross-Sectional Quantitative Metabolomics Study Evidencing the Metabolic Signature in Six Organs during a 14-Week High-Fat High-Sucrose and Standard Diet in Mice
by Eva Drevet Mulard, Sylvie Guibert, Anne Mey, Camille Lefevre, Marie-Agnès Chauvin, Claudie Pinteur, Marie-Ambre Monet, Murielle Godet, Anne-Marie Madec, Béatrice Morio, Jennifer Rieusset, Gilles J. P. Rautureau and Baptiste Panthu
Nutrients 2024, 16(6), 803; https://doi.org/10.3390/nu16060803 - 12 Mar 2024
Viewed by 794
Abstract
Obesity is a risk factor for many diseases, such as type 2 diabetes and cardiovascular diseases. In line with the need for precision medicine, the search for biomarkers reporting the progression of obesity- and diet-associated disorders is urgent. We used NMR to determine [...] Read more.
Obesity is a risk factor for many diseases, such as type 2 diabetes and cardiovascular diseases. In line with the need for precision medicine, the search for biomarkers reporting the progression of obesity- and diet-associated disorders is urgent. We used NMR to determine the metabolomics profile of key organs (lung, liver, heart, skeletal muscle, kidney, and brain) and serum from male C57Bl/6J mice (5 weeks old) fed for 6, 10, and 14 weeks on a high-fat and high-sucrose diet (HFHSD) vs. a standard diet (STD). We determined metabolite concentrations in the organs at each time point, which allowed us to discriminate age- and diet-related effects as well as the interactions between both, highlighting the need to evaluate the influence of age as a confounding factor on metabolic signatures. Notably, the analysis revealed the influence of time on metabolite concentrations in the STD condition, probably reflecting the juvenile-to-adult transition. Variations impacted the liver and lung metabolites, revealing the strong influence of the HFHS diet on normal metabolism maturation during youth. Full article
(This article belongs to the Special Issue Metabolic Diseases and Lipid Metabolism Regulators)
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11 pages, 577 KiB  
Article
Regular Practice of Physical Activity Improves Cholesterol Transfers to High-Density Lipoprotein (HDL) and Other HDL Metabolic Parameters in Older Adults
by Pedro G. S. Braga, Fatima R. Freitas, André L. L. Bachi, Gislene R. Amirato, Roberta V. Baroni, Maria Janieire N. N. Alves, Rodolfo P. Vieira, Mauro W. Vaisberg, Marlene N. Aldin, Roberto Kalil Filho, Antônio M. Figueiredo Neto, Nágila R. T. Damasceno, Thauany M. Tavoni and Raul C. Maranhão
Nutrients 2023, 15(23), 4871; https://doi.org/10.3390/nu15234871 - 22 Nov 2023
Cited by 1 | Viewed by 1115
Abstract
The effects of regular physical activity on two important anti-atherosclerosis functions of high-density lipoprotein (HDL), namely its capacity to receive both forms of cholesterol and its anti-oxidant function, were investigated in this study comparing older adults with young individuals. One-hundred and eight healthy [...] Read more.
The effects of regular physical activity on two important anti-atherosclerosis functions of high-density lipoprotein (HDL), namely its capacity to receive both forms of cholesterol and its anti-oxidant function, were investigated in this study comparing older adults with young individuals. One-hundred and eight healthy adult individuals were enrolled and separated into the following groups: active older (60–80 yrs, n = 24); inactive older (60–79 yrs, n = 21); active young (20–34 yrs, n = 39); and inactive young (20–35 yrs, n = 24). All performed cardiopulmonary tests. Blood samples were collected in order to assess the following measures: lipid profile, HDL anti-oxidant capacity, paraoxonase-1 activity, HDL subfractions, and lipid transfer to HDL. Comparing active older and active young groups with inactive older and inactive young groups, respectively, the active groups presented higher HDL-C levels (p < 0.01 for both comparisons), unesterified cholesterol transfer (p < 0.01, p < 0.05), and intermediate and larger HDL subfractions (p < 0.001, p < 0.01) than the respective inactive groups. In addition, the active young group showed higher esterified cholesterol transfer than the inactive young group (p < 0.05). As expected, the two active groups had higher VO2peak than the inactive groups; VO2peak was higher in the two younger than in the two older groups (p < 0.05). No differences in unesterified and esterified cholesterol transfers and HDL subfractions were found between active young and active older groups. HDL anti-oxidant capacity and paraoxonase-1 activity were equal in all four study groups. Our data highlight and strengthen the benefits of regular practice of physical activity on an important HDL function, the capacity of HDL to receive cholesterol, despite the age-dependent decrease in VO2peak. Full article
(This article belongs to the Special Issue Metabolic Diseases and Lipid Metabolism Regulators)
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14 pages, 3126 KiB  
Article
Palmitic Acid Modulates Microglial Cell Response to Metabolic Endotoxemia in an In Vitro Study
by Mateusz Chmielarz, Beata Sobieszczańska, Andrzej Teisseyre, Magdalena Wawrzyńska, Edyta Bożemska and Kamila Środa-Pomianek
Nutrients 2023, 15(15), 3463; https://doi.org/10.3390/nu15153463 - 5 Aug 2023
Viewed by 1274
Abstract
Metabolic endotoxemia (ME) is characterized by a 2–3-fold increase in blood endotoxin levels and low-grade systemic inflammation without apparent infection. ME is usually accompanied by metabolic syndrome, characterized by central obesity and hyperlipidemia. According to numerous studies, ME may lead to functional brain [...] Read more.
Metabolic endotoxemia (ME) is characterized by a 2–3-fold increase in blood endotoxin levels and low-grade systemic inflammation without apparent infection. ME is usually accompanied by metabolic syndrome, characterized by central obesity and hyperlipidemia. According to numerous studies, ME may lead to functional brain disorders, including cognitive decline, depression, and dementia. In the current in vitro study, we aimed to determine the direct and indirect impact of endotoxin (LPS) and palmitic acid (PA), representing saturated fatty acids, on the inflammatory and oxidative stress response in the human microglial HMC3 cells unstimulated and stimulated with IFNγ. The study’s results revealed that direct HMC3 cell exposition to endotoxin and PA increased inflammatory response measured as levels of IL-6 and MCP-1 released into the medium and PGE2 levels in cell lysates. Moreover, direct HMC3 cell treatment with PA and LPS induced oxidative stress, i.e., ROS and COX-2 production and lipid peroxidation. On the contrary, an indirect effect of LPS and PA on microglial cells, assessed as the impact of macrophage metabolites, was much lower regarding the inflammatory response, although still associated with oxidative stress. Interestingly, IFNγ had a protective effect on microglial cells, reducing the production of pro-inflammatory mediators and oxidative stress in HMC3 cells treated directly and indirectly with LPS and PA. Full article
(This article belongs to the Special Issue Metabolic Diseases and Lipid Metabolism Regulators)
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