Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.1
5.0
Journals
Nutrients
Special Issues
Nutritional Bioactive Components and Lipid Metabolic Diseases: A Comprehensive Exploration
nutrients-logo
Submit to Special Issue Submit Abstract to Special Issue Review for Nutrients Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Nutritional Bioactive Components and Lipid Metabolic Diseases: A Comprehensive Exploration

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Lipids".

Deadline for manuscript submissions: 15 August 2026 | Viewed by 7895

Special Issue Editor

Dr. Zhen Chen

E-Mail Website
Guest Editor
School of Pharmacy, Jiangsu University, Zhenjiang 212013, China
Interests: functional foods; lipid metabolism; nutritional interventions; oxidative stress; antioxidants; mitochondria function
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce the launch of the Special Issue of Nutrients titled “Nutritional Bioactive Components and Lipid Metabolic Diseases: A Comprehensive Exploration.”

Lipid metabolism plays a central role in numerous health conditions, and its dysregulation is closely linked to various metabolic diseases. In this context, nutritional bioactive components have attracted growing interest for their possible preventive and therapeutic roles. This Special Issue aims to provide a broad yet focused platform for current research exploring the interface between nutrition, bioactive components, and lipid-related metabolic disorders.

By assembling this pioneering knowledge repository, we aim to connect the dots between lipid biochemistry, metabolic disease research, clinical applications, and nutritional insights. We are particularly interested in submissions of original research articles and comprehensive reviews that explore the mechanisms from molecular, clinical, or translational perspectives. Studies elucidating the molecular pathways mediated by bioactive nutraceuticals, their contribution to disease prevention and management, and innovative therapeutics, with an eye toward nutritional interventions, are highly encouraged. We look forward to receiving your contributions.

Dr. Zhen Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutritional bioactive components
  • lipid metabolism
  • metabolic diseases
  • nutraceuticals
  • functional foods
  • dietary lipids
  • inflammation and metabolism
  • obesity-related disorders
  • non-alcoholic fatty liver disease (NAFLD)
  • bioactive compound mechanisms
  • translational nutrition research
  • prebiotics
  • novel food

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

20 pages, 2298 KB  
Article
Effect of 4-Week Consumption of “Navelina” Oranges on Serum Lipid Profile in Patients with MASLD: Evidence from a Randomized Clinical Trial
by Valentina De Nunzio, Giuliano Pinto, Davide Guido, Emanuela Aloisio Caruso, Miriam Cofano, Ilenia Saponara, Matteo Centonze, Maria Grazia Refolo and Maria Notarnicola
Nutrients 2026, 18(8), 1254; https://doi.org/10.3390/nu18081254 - 16 Apr 2026
Viewed by 1061
Abstract
Background: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) refers to fatty liver disease associated with metabolic syndrome. MASLD causes alterations in lipid metabolism, which can be regulated with a diet rich in polyphenols. The present study aims to evaluate the effects of daily consumption [...] Read more.
Background: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) refers to fatty liver disease associated with metabolic syndrome. MASLD causes alterations in lipid metabolism, which can be regulated with a diet rich in polyphenols. The present study aims to evaluate the effects of daily consumption of 400 g of “Navelina” oranges for 4 weeks on serum lipid profiles in a group of 60 patients with MASLD, to identify specific lipid species associated with improvements in hepatic steatosis. Methods: Blood samples were collected from all participants, and biochemical measurements and a serum lipidomic profile were performed. Finally, a Spearman correlation analysis was used to assess the relationships between serum lipidomic fatty acids and biochemical lipid markers. Results: In the experimental treatment arm, serum lipidomic analysis showed a slight decrease in Arachidonic acid (AA) and the Arachidonic acid/Eicosapentaenoic acid ratio (AA/EPA ratio) but no significant interaction between time and treatment was detected. In the same group, Oleic acid, MUFAs and the AA/EPA ratio were significantly and negatively correlated with HDL (r = −0.368, p = 0.046), (r = −0.384, p = 0.036), and (r = −0.522, p = 0.003), respectively. Conversely, EPA and n-3 PUFAs were positively and significantly correlated with HDL (r = 0.447, p = 0.013) and (r = 0.403, p = 0.027) respectively. Conclusions: Furthermore, this study represents one of the first clinical trials to shed a light on the potential association of “Navelina” orange polyphenols on serum fatty acid profiles in patients with MASLD, supporting studies on the nutraceutical effect of oranges on lipid metabolism. Full article
(This article belongs to the Special Issue Nutritional Bioactive Components and Lipid Metabolic Diseases: A Comprehensive Exploration)
►▼ Show Figures

Figure 1

Review

Jump to: Research

18 pages, 1640 KB  
Review
The Changes in Plasmalogens: Chemical Diversity and Nutritional Implications—A Narrative Review
by Zhen Chen, Chen Dong, Lin Chen, Meiling Song, Xinxin Zhou, Depeng Lv and Quancai Li
Nutrients 2025, 17(22), 3497; https://doi.org/10.3390/nu17223497 - 7 Nov 2025
Cited by 2 | Viewed by 3160
Abstract
Plasmalogens, as natural dietary lipids, are a unique class of glycerophospholipids with distinct structural and functional properties. They are unstable due to the vinyl ether linkage and the unsaturated fatty chains. Hence, plasmalogen changes are closely connected to their beneficial bioactivities and health-related [...] Read more.
Plasmalogens, as natural dietary lipids, are a unique class of glycerophospholipids with distinct structural and functional properties. They are unstable due to the vinyl ether linkage and the unsaturated fatty chains. Hence, plasmalogen changes are closely connected to their beneficial bioactivities and health-related applications. This narrative review focuses on their structural modifications, particularly oxidation of the vinyl-ether and sn-2 acyl chains, enzymatic degradation, and molecular remodeling. The oxidative susceptibility of plasmalogens renders them particularly vulnerable under inflammatory or oxidative stress, contributing to a measurable reduction in total plasmalogen content. Plasmalogen deficiency has been observed in various diseases and applied in clinical applications, including physiological and a variety of pathological conditions. Moreover, plasmalogens have been recognized as not only disease biomarkers but also therapeutic targets. In addition, recent findings in nutrition were discussed, aiming to find that underutilized animal byproducts and microbial lipids are promising new sources of plasmalogens. To conclude, it is crucial to establish practical dynamic monitoring systems of plasmalogens for health promotion and disease prevention interventions. Integrating biochemical pathways, clinical diagnosis, and nutritional interventions remains to be clarified. Full article
(This article belongs to the Special Issue Nutritional Bioactive Components and Lipid Metabolic Diseases: A Comprehensive Exploration)
►▼ Show Figures

Figure 1

31 pages, 2410 KB  
Review
Mentha Essential Oils: Unraveling Chemotype-Dependent Biosynthesis and Assessing Evidence for Health-Promoting Activities
by Yifan Yu, Yalin Ma, Zhen Ouyang and Luqi Huang
Nutrients 2025, 17(20), 3258; https://doi.org/10.3390/nu17203258 - 16 Oct 2025
Cited by 4 | Viewed by 3258
Abstract
Mentha essential oils (EOs), renowned for their distinctive aromas and diverse biological activities, represent a key focus in phytochemical and pharmacological research. While numerous reviews have documented the general properties of mint EOs, a systematic and critical synthesis of recent advances linking chemotypic [...] Read more.
Mentha essential oils (EOs), renowned for their distinctive aromas and diverse biological activities, represent a key focus in phytochemical and pharmacological research. While numerous reviews have documented the general properties of mint EOs, a systematic and critical synthesis of recent advances linking chemotypic diversity to biosynthetic mechanisms and evidence-based health benefits remains lacking. This review aims to address this gap by comprehensively analyzing the structural variability of EOs across major Mentha species, elucidating the chemotype-dependent enzymatic and genetic regulation within the plastidial methylerythritol phosphate (MEP) pathway, and evaluating preclinical and clinical evidence supporting their health-promoting activities, including antimicrobial, antioxidant, anti-inflammatory, digestive, respiratory, cognitive-enhancing, and anticancer effects. By integrating findings from cutting-edge transcriptomic and genomic studies, we highlight how genetic variations and epigenetic factors influence monoterpene biosynthesis and ultimately shape bioactivity profiles. Furthermore, we critically assess challenges related to EO standardization, bioavailability, and clinical translation, and propose interdisciplinary strategies, such as metabolic engineering, nano-delivery systems, and structured clinical trial designs to overcome these barriers. This review not only consolidates the current understanding of Mentha Eos, but also provides a forward-looking perspective on their potential applications in functional foods, pharmaceuticals, and personalized health products. Full article
(This article belongs to the Special Issue Nutritional Bioactive Components and Lipid Metabolic Diseases: A Comprehensive Exploration)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop