Nutritional Genomics

Dear Colleagues,

After the sequencing of the human genome and that of model organisms, nutritional genomics is becoming an essential part of modern nutrition science. Nutritional genomics applies non-hypothesis-driven, high-throughput methodologies and systems biology approaches to study the relationship between the genome, nutrition, and health. It seeks to define biomarkers, biological targets and the mechanisms of action of dietary factors, both in health and disease states, particularly diet-related complex diseases such as obesity. Its scope is extending as this young science develops, from single dietary chemicals/foods to complete diets; from a focus on genetic traits, to the consideration of additional individual’s traits affecting responses to diet, such as epigenetics and microbiota profiles; from a focus on protein coding genes, to the consideration of non-coding RNAs as well, in view of their role in the control of metabolism and evidence for their dietary regulation. Besides classical nutriomics (e.g. genomics, transcriptomics, proteomics, metabolomics), the influence of nutrition and dietary factors on transcription factor occupancy and chromatin structure can now be studied at a genome-wide level. The development of nutritional genomics is extending our understanding of biology and allowing the definition of personalized dietary recommendations for health preservation. We expect these different aspects to be covered in this special issue of Nutrients on “Nutritional genomics”.

Prof. Dr. M. Luisa Bonet
Dr. Juana Sánchez
Guest Editors

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