Physiological and Transcriptional Responses in Weaned Piglets Fed Diets with Varying Phosphorus and Calcium Levels

Gerlinger, Christian; Oster, Michael; Borgelt, Luisa; Reyer, Henry; Muráni, Eduard; Ponsuksili, Siriluck; Polley, Christian; Vollmar, Brigitte; Reichel, Martin; Wolf, Petra; Wimmers, Klaus

doi:10.3390/nu11020436

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Physiological and Transcriptional Responses in Weaned Piglets Fed Diets with Varying Phosphorus and Calcium Levels

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Leibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany

Nutrition Physiology and Animal Nutrition, University of Rostock, Justus-von-Liebig-Weg 6b, 18059 Rostock, Germany

Institute for Experimental Surgery, University Medicine Rostock, Schillingallee 69a, 18057 Rostock, Germany

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Mechanical Engineering Design/Lightweight Design, University of Rostock, Albert-Einstein-Straße 2, 18059 Rostock, Germany

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Animal Breeding and Genetics, University of Rostock, Justus-von-Liebig-Weg 7, 18059 Rostock, Germany

Author to whom correspondence should be addressed.

Nutrients 2019, 11(2), 436; https://doi.org/10.3390/nu11020436

Received: 23 January 2019 / Revised: 14 February 2019 / Accepted: 18 February 2019 / Published: 20 February 2019

(This article belongs to the Special Issue Nutritional Genomics)

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Abstract

Phosphorus (P) is an important element of various metabolic and signalling processes, including bone metabolism and immune function. To elucidate the routes of P homeostasis and utilization, a five-week feeding study was conducted with weaned piglets receiving a diet with recommended amounts of P and Ca (M), or a diet with lower (L) or higher (H) P values and a constant Ca:P ratio. Routes of P utilization were deduced via bone characteristics (MicroCT), genome-wide transcriptomic profiles of peripheral blood mononuclear cells (PBMCs), and serum mineral levels. MicroCT revealed significantly lower bone mineral density, trabecular number, and mechanical fracture load in (L). Gene expression analyses showed transcripts of 276 and 115 annotated genes with higher or lower abundance in (H) than (L) that were related to basic cellular and metabolic processes as well as response to stimuli, developmental processes and immune system processes. This study shows the many molecular routes involved in P homeostasis that should be considered to improve endogenous mechanisms of P utilization. View Full-Text

Keywords: calcium homeostasis; dietary mineral intake; immunomodulation; phosphorus homeostasis; trabecular bone

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Gerlinger, C.; Oster, M.; Borgelt, L.; Reyer, H.; Muráni, E.; Ponsuksili, S.; Polley, C.; Vollmar, B.; Reichel, M.; Wolf, P.; Wimmers, K. Physiological and Transcriptional Responses in Weaned Piglets Fed Diets with Varying Phosphorus and Calcium Levels. Nutrients 2019, 11, 436. https://doi.org/10.3390/nu11020436

AMA Style

Gerlinger C, Oster M, Borgelt L, Reyer H, Muráni E, Ponsuksili S, Polley C, Vollmar B, Reichel M, Wolf P, Wimmers K. Physiological and Transcriptional Responses in Weaned Piglets Fed Diets with Varying Phosphorus and Calcium Levels. Nutrients. 2019; 11(2):436. https://doi.org/10.3390/nu11020436

Chicago/Turabian Style

Gerlinger, Christian, Michael Oster, Luisa Borgelt, Henry Reyer, Eduard Muráni, Siriluck Ponsuksili, Christian Polley, Brigitte Vollmar, Martin Reichel, Petra Wolf, and Klaus Wimmers. 2019. "Physiological and Transcriptional Responses in Weaned Piglets Fed Diets with Varying Phosphorus and Calcium Levels" Nutrients 11, no. 2: 436. https://doi.org/10.3390/nu11020436

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Physiological and Transcriptional Responses in Weaned Piglets Fed Diets with Varying Phosphorus and Calcium Levels

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