Nutrients 2019, 11(2), 436; https://doi.org/10.3390/nu11020436
Physiological and Transcriptional Responses in Weaned Piglets Fed Diets with Varying Phosphorus and Calcium Levels
Christian Gerlinger 1,2
, Michael Oster 1, Luisa Borgelt 2, Henry Reyer 1, Eduard Muráni 1, Siriluck Ponsuksili 1, Christian Polley 3, Brigitte Vollmar 3, Martin Reichel 4, Petra Wolf 2 and Klaus Wimmers 1,5,*
, Michael Oster 1, Luisa Borgelt 2, Henry Reyer 1, Eduard Muráni 1, Siriluck Ponsuksili 1, Christian Polley 3, Brigitte Vollmar 3, Martin Reichel 4, Petra Wolf 2 and Klaus Wimmers 1,5,*
1
Leibniz Institute for Farm Animal Biology, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany
2
Nutrition Physiology and Animal Nutrition, University of Rostock, Justus-von-Liebig-Weg 6b, 18059 Rostock, Germany
3
Institute for Experimental Surgery, University Medicine Rostock, Schillingallee 69a, 18057 Rostock, Germany
4
Mechanical Engineering Design/Lightweight Design, University of Rostock, Albert-Einstein-Straße 2, 18059 Rostock, Germany
5
Animal Breeding and Genetics, University of Rostock, Justus-von-Liebig-Weg 7, 18059 Rostock, Germany
*
Author to whom correspondence should be addressed.
Received: 23 January 2019 / Revised: 14 February 2019 / Accepted: 18 February 2019 / Published: 20 February 2019
(This article belongs to the Special Issue Nutritional Genomics)
Abstract
Phosphorus (P) is an important element of various metabolic and signalling processes, including bone metabolism and immune function. To elucidate the routes of P homeostasis and utilization, a five-week feeding study was conducted with weaned piglets receiving a diet with recommended amounts of P and Ca (M), or a diet with lower (L) or higher (H) P values and a constant Ca:P ratio. Routes of P utilization were deduced via bone characteristics (MicroCT), genome-wide transcriptomic profiles of peripheral blood mononuclear cells (PBMCs), and serum mineral levels. MicroCT revealed significantly lower bone mineral density, trabecular number, and mechanical fracture load in (L). Gene expression analyses showed transcripts of 276 and 115 annotated genes with higher or lower abundance in (H) than (L) that were related to basic cellular and metabolic processes as well as response to stimuli, developmental processes and immune system processes. This study shows the many molecular routes involved in P homeostasis that should be considered to improve endogenous mechanisms of P utilization. View Full-TextKeywords:
calcium homeostasis; dietary mineral intake; immunomodulation; phosphorus homeostasis; trabecular bone
▼
Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
Share & Cite This Article
MDPI and ACS Style
Gerlinger, C.; Oster, M.; Borgelt, L.; Reyer, H.; Muráni, E.; Ponsuksili, S.; Polley, C.; Vollmar, B.; Reichel, M.; Wolf, P.; Wimmers, K. Physiological and Transcriptional Responses in Weaned Piglets Fed Diets with Varying Phosphorus and Calcium Levels. Nutrients 2019, 11, 436.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Related Articles
Article Metrics
Comments
[Return to top]
Nutrients
EISSN 2072-6643
Published by MDPI AG, Basel, Switzerland
RSS
E-Mail Table of Contents Alert