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Biomarkers of Nutrition and Health: New Tools for New Approaches

1
Laboratory of Molecular Biology, Nutrition and Biotechnology (Group of Nutrigenomics and Obesity), CIBER de Fisiopatología de la Obesidad y Nutrición (CIBERobn) and Instituto de Investigación Sanitaria Illes Balears (IdISBa), University of the Balearic Islands, ES-07122 Palma de Mallorca, Spain
2
Human and Animal Physiology, Wageningen University, PO Box 338, 6700 AH Wageningen, The Netherlands
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(5), 1092; https://doi.org/10.3390/nu11051092
Received: 4 April 2019 / Revised: 7 May 2019 / Accepted: 8 May 2019 / Published: 16 May 2019
(This article belongs to the Special Issue Nutritional Genomics)
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PDF [746 KB, uploaded 22 May 2019]
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Abstract

A main challenge in nutritional studies is the valid and reliable assessment of food intake, as well as its effects on the body. Generally, food intake measurement is based on self-reported dietary intake questionnaires, which have inherent limitations. They can be overcome by the use of biomarkers, capable of objectively assessing food consumption without the bias of self-reported dietary assessment. Another major goal is to determine the biological effects of foods and their impact on health. Systems analysis of dynamic responses may help to identify biomarkers indicative of intake and effects on the body at the same time, possibly in relation to individuals’ health/disease states. Such biomarkers could be used to quantify intake and validate intake questionnaires, analyse physiological or pathological responses to certain food components or diets, identify persons with specific dietary deficiency, provide information on inter-individual variations or help to formulate personalized dietary recommendations to achieve optimal health for particular phenotypes, currently referred as “precision nutrition.” In this regard, holistic approaches using global analysis methods (omics approaches), capable of gathering high amounts of data, appear to be very useful to identify new biomarkers and to enhance our understanding of the role of food in health and disease. View Full-Text
Keywords: food intake assessment; integrative biomarkers; omics technologies; precision nutrition food intake assessment; integrative biomarkers; omics technologies; precision nutrition
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Picó, C.; Serra, F.; Rodríguez, A.M.; Keijer, J.; Palou, A. Biomarkers of Nutrition and Health: New Tools for New Approaches. Nutrients 2019, 11, 1092.

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