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Nutrients
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Nutrition and Cognition in Health and Disease
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Nutrition and Cognition in Health and Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Lipids".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 12153

Special Issue Editors

Prof. Mara Dierssen

E-Mail Website
Guest Editor
IMIM-Hospital del Mar Medical Research Institute, E-08003 Barcelona, Spain; University Pompeu Fabra (CEXS-UPF), E-08003 Barcelona, Spain; Center for Genomic Regulation (CRG), E-08003 Barcelona, Spain; CIBER of Rare Diseases (CIBERER), E-08003 Barcelona, Spain; The Barcelona Institute of Science and Technology, E-08003 Barcelona, Spain
Interests: neurodevelopmental disorders; non-pharmacological therapy; nutraceutics; mouse models; omics
Prof. Rafael de la Torre

E-Mail Website
Guest Editor
Cardiovascular Risk and Nutrition Research Group, Hospital del Mar Medical Research Institute (IMIM), Dr. Aiguader 88, 08003 Barcelona, Spain
Interests: neurodevelopmental disorders; non-pharmacological therapy; nutraceutics; mouse models; omics

Special Issue Information

Dear Colleagues,

Increasing evidence suggests that obesity and poor diet can lead to negative cognitive implications and mood dysfunction, suggesting a strong interaction between diet and cognition. Nutrition is thus an important lifestyle factor that can modify cognitive development, functioning and age-associated cognitive impairment and dementia. Some evidence exists of an association between certain nutrients (flavonoids, vitamin D, or certain lipids) or food groups (seafood, vegetables, or fruits) and cognitive outcomes. This evidence is somehow stronger for healthy diets, such as the Mediterranean-type diet, possibly because of their cumulative beneficial effects.

This special issue will include evidence-based studies and reviews of cognitive effects of specific bioactive nutrients and nutritional and/or dietary interventions that might hold some promise for the prevention of cognitive impairment and dementia. It will also welcome studies addressing possible mechanisms of action, including but not limited to interactions of the digestive, immune, and nervous systems, diet-induced gut dysbiosis or others such as metabolic mechanisms and neuroinflammation.

Prof. Mara Dierssen

Prof. Rafael de la Torre
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Nutrition

  • Nurodevelopmental disorders

  • Cognitition
  • Mood dysfunction;
  • Dementia
  • Cognitive development
  • Bioactive nutrients
  • Vitamin D
  • Seafood
  • Phytochemicals
  • Mediterranean diet
  • Neuroinflammation

Published Papers (3 papers)

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Research

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13 pages, 507 KiB  
Article
Metabolic, Affective and Neurocognitive Characterization of Metabolic Syndrome Patients with and without Food Addiction. Implications for Weight Progression
by Lucía Camacho-Barcia, Lucero Munguía, Ignacio Lucas, Rafael de la Torre, Jordi Salas-Salvadó, Xavier Pintó, Dolores Corella, Roser Granero, Susana Jiménez-Murcia, Inmaculada González-Monje, Virginia Esteve-Luque, Aida Cuenca-Royo, Carlos Gómez-Martínez, Indira Paz-Graniel, Laura Forcano and Fernando Fernández-Aranda
Nutrients 2021, 13(8), 2779; https://doi.org/10.3390/nu13082779 - 13 Aug 2021
Cited by 5 | Viewed by 3991
Abstract
According to the food addiction (FA) model, the consumption of certain types of food could be potentially addictive and can lead to changes in intake regulation. We aimed to describe metabolic parameters, dietary characteristics, and affective and neurocognitive vulnerabilities of individuals with and [...] Read more.
According to the food addiction (FA) model, the consumption of certain types of food could be potentially addictive and can lead to changes in intake regulation. We aimed to describe metabolic parameters, dietary characteristics, and affective and neurocognitive vulnerabilities of individuals with and without FA, and to explore its influences on weight loss progression. The sample included 448 adults (55–75 years) with overweight/obesity and metabolic syndrome from the PREDIMED-Plus cognition sub-study. Cognitive and psychopathological assessments, as well as dietary, biochemical, and metabolic measurements, were assessed at baseline. Weight progression was evaluated after a 3-year follow up. The presence of FA was associated with higher depressive symptomatology, neurocognitive decline, low quality of life, high body mass index (BMI), and high waist circumference, but not with metabolic comorbidities. No differences were observed in the dietary characteristics except for the saturated and monounsaturated fatty acids consumption. After three years, the presence of FA at baseline resulted in a significantly higher weight regain. FA is associated with worse psychological and neurocognitive state and higher weight regain in adults with metabolic syndrome. This condition could be an indicator of bad prognosis in the search for a successful weight loss process. Full article
(This article belongs to the Special Issue Nutrition and Cognition in Health and Disease)
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Review

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22 pages, 1575 KiB  
Review
Catechins as a Potential Dietary Supplementation in Prevention of Comorbidities Linked with Down Syndrome
by Christophe Noll, Janany Kandiah, Gautier Moroy, Yuchen Gu, Julien Dairou and Nathalie Janel
Nutrients 2022, 14(10), 2039; https://doi.org/10.3390/nu14102039 - 12 May 2022
Cited by 5 | Viewed by 2674
Abstract
Plant-derived polyphenols flavonoids are increasingly being recognized for their medicinal potential. These bioactive compounds derived from plants are gaining more interest in ameliorating adverse health risks because of their low toxicity and few side effects. Among them, therapeutic approaches demonstrated the efficacy of [...] Read more.
Plant-derived polyphenols flavonoids are increasingly being recognized for their medicinal potential. These bioactive compounds derived from plants are gaining more interest in ameliorating adverse health risks because of their low toxicity and few side effects. Among them, therapeutic approaches demonstrated the efficacy of catechins, a major group of flavonoids, in reverting several aspects of Down syndrome, the most common genomic disorder that causes intellectual disability. Down syndrome is characterized by increased incidence of developing Alzheimer’s disease, obesity, and subsequent metabolic disorders. In this focused review, we examine the main effects of catechins on comorbidities linked with Down syndrome. We also provide evidence of catechin effects on DYRK1A, a dosage-sensitive gene encoding a protein kinase involved in brain defects and metabolic disease associated with Down syndrome. Full article
(This article belongs to the Special Issue Nutrition and Cognition in Health and Disease)
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33 pages, 8334 KiB  
Review
Therapeutic Effects of Catechins in Less Common Neurological and Neurodegenerative Disorders
by Giorgia Sebastiani, Laura Almeida-Toledano, Mariona Serra-Delgado, Elisabet Navarro-Tapia, Sebastian Sailer, Olga Valverde, Oscar Garcia-Algar and Vicente Andreu-Fernández
Nutrients 2021, 13(7), 2232; https://doi.org/10.3390/nu13072232 - 29 Jun 2021
Cited by 23 | Viewed by 4572
Abstract
In recent years, neurological and neurodegenerative disorders research has focused on altered molecular mechanisms in search of potential pharmacological targets, e.g., imbalances in mechanisms of response to oxidative stress, inflammation, apoptosis, autophagy, proliferation, differentiation, migration, and neuronal plasticity, which occur in less common [...] Read more.
In recent years, neurological and neurodegenerative disorders research has focused on altered molecular mechanisms in search of potential pharmacological targets, e.g., imbalances in mechanisms of response to oxidative stress, inflammation, apoptosis, autophagy, proliferation, differentiation, migration, and neuronal plasticity, which occur in less common neurological and neurodegenerative pathologies (Huntington disease, multiple sclerosis, fetal alcohol spectrum disorders, and Down syndrome). Here, we assess the effects of different catechins (particularly of epigalocatechin-3-gallate, EGCG) on these disorders, as well as their use in attenuating age-related cognitive decline in healthy individuals. Antioxidant and free radical scavenging properties of EGCG -due to their phenolic hydroxyl groups-, as well as its immunomodulatory, neuritogenic, and autophagic characteristics, makes this catechin a promising tool against neuroinflammation and microglia activation, common in these pathologies. Although EGCG promotes the inhibition of protein aggregation in experimental Huntington disease studies and improves the clinical severity in multiple sclerosis in animal models, its efficacy in humans remains controversial. EGCG may normalize DYRK1A (involved in neural plasticity) overproduction in Down syndrome, improving behavioral and neural phenotypes. In neurological pathologies caused by environmental agents, such as FASD, EGCG enhances antioxidant defense and regulates placental angiogenesis and neurodevelopmental processes. As demonstrated in animal models, catechins attenuate age-related cognitive decline, which results in improvements in long-term outcomes and working memory, reduction of hippocampal neuroinflammation, and enhancement of neuronal plasticity; however, further studies are needed. Catechins are valuable compounds for treating and preventing certain neurodegenerative and neurological diseases of genetic and environmental origin. However, the use of different doses of green tea extracts and EGCG makes it difficult to reach consistent conclusions for different populations. Full article
(This article belongs to the Special Issue Nutrition and Cognition in Health and Disease)
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