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Nutrients
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Nutrition and Dietary Intake in Liver-Related Diseases
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Nutrition and Dietary Intake in Liver-Related Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: closed (5 January 2025) | Viewed by 5433

Special Issue Editors

Prof. Dr. Dae Won Jun

E-Mail Website
Guest Editor
Internal Medicine, Hanyang University, Seoul 133-791, Republic of Korea
Interests: non-alcoholic fatty liver disease; sarcopenia; liver; cirrhosis; adjustment
Special Issues, Collections and Topics in MDPI journals
Dr. Jun-Hyuk Lee

E-Mail Website
Co-Guest Editor
Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Republic of Korea
Interests: clinical nutrition; fatty liver; metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nutrition exerts a profound influence on not just the etiology but also the pathogenesis of liver disease. Historically, it has been recognized that chronic illnesses can precipitate malnutrition, particularly cirrhosis. Conversely, malnutrition has been identified as a contributing factor to the progression of these hepatic conditions.

Recently, the prevalence of steatotic liver disease, commonly known as fatty liver, has risen steeply in parallel with the global surge in obesity rates. This has led to an expanded conceptualization of malnutrition to encompass over-nutrition, alongside the conventional issue of under-nutrition.

Both states of malnutrition, whether characterized by deficits or excesses in nutritional intake, exert multifaceted influences on the development and trajectory of chronic liver diseases. Our overarching goal is to provide an extensive forum for the dissemination of diverse viewpoints, empirical research findings, and international guidelines pertinent to the intricate interplay between nutrition and chronic liver diseases. This includes elucidating diagnostic and therapeutic methodologies.

We cordially invite scholarly contributions that adopt a holistic perspective, encompassing broader aspects such as overall health, physical activity, and lifestyle interventions. These contributions may offer insights into diagnostic and therapeutic modalities tailored to individuals afflicted by chronic liver diseases. Additionally, we welcome submissions that delve into optimal nutritional interventions and articles with a focal point on chronic liver disease.

Furthermore, we encourage submissions elucidating the interface between nutrition and sarcopenia, a recognized significant mediator in the realm of chronic liver diseases. Of particular interest are the latest research findings concerning the intricate interrelationships between genetic factors and nutrition, as well as innovative multi-omics-based methodologies for the diagnosis and management of nutritional status. The intricate interplay between genetic and environmental factors, in conjunction with nutritional status, occupies a pivotal role in the multifaceted pathogenesis of chronic liver diseases.

Given the intricate and multifaceted nature of the relationship between nutrition and chronic liver diseases, this dedicated Special Issue aims to provide an encompassing platform. Our objective is to elucidate the theoretical underpinnings, practical applications, and clinical relevance of weight management and nutritional strategies within the context of chronic liver diseases, thereby contributing to the advancement of scientific knowledge in this critical domain.

Prof. Dr. Dae Won Jun
Dr. Jun-Hyuk Lee
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrients
  • liver disease
  • steatotic liver disease
  • alcohol
  • fatty liver
  • over-nutrition
  • malnutrition
  • sarcopenia

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Published Papers (3 papers)

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Research

18 pages, 4142 KiB  
Article
Antarctic Krill Euphausia superba Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice
by Jun-Hui Choi, Se-Eun Park and Seung Kim
Nutrients 2024, 16(21), 3614; https://doi.org/10.3390/nu16213614 - 24 Oct 2024
Viewed by 1569
Abstract
Background: Several Previous studies indicate that consuming krill oil may aid in reducing hypercholesterolemia and improving cholesterol metabolism. Therefore, our study was designed to investigate the effectiveness of Antarctic krill oil (Euphausia superba) (ESKO) in combating obesity and lowering fat/lipid/cholesterol levels. [...] Read more.
Background: Several Previous studies indicate that consuming krill oil may aid in reducing hypercholesterolemia and improving cholesterol metabolism. Therefore, our study was designed to investigate the effectiveness of Antarctic krill oil (Euphausia superba) (ESKO) in combating obesity and lowering fat/lipid/cholesterol levels. Methods: The study aimed to investigate the molecular docking model targeting 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) using ESKO-derived eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and astaxanthin. In this study, histological alterations in the liver of the obesity model (ICR male mouse), obesity-related or antioxidant markers in both liver and serum, the molecular mechanisms in HepG2 cells and liver tissue, and HMGCR activity were analyzed. Results: Our findings revealed that a high-fat diet (HFD) significantly led to increased oxidative stress, obesity-related indicators, and cardiovascular-associated risk indices. However, ESKO effectively mitigated HFD-induced oxidative stress, fat accumulation, and the suppression of low-density lipoprotein receptor (LDLR) or activation of related molecular pathways. This was achieved through improvements in metabolic parameters, including CD36/liver X receptor α (LXRα)/sterol regulatory element-binding protein 1c (SREBP1c), proprotein convertase subtilsin/kexin type 9 (PCSK-9), and HMGCR, ultimately ameliorating HFD-induced hypercholesterolemia and obesity. Conclusions: These beneficial findings indicate that ESKO might have significant potential for preventing and treating obesity-related disorders. Full article
(This article belongs to the Special Issue Nutrition and Dietary Intake in Liver-Related Diseases)
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16 pages, 564 KiB  
Article
A Dose–Response Study on the Relationship between White Meat Intake and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Southern Italy: Results from the Nutrihep Study
by Davide Guido, Nicole Cerabino, Martina Di Chito, Rossella Donghia, Cristiana Randazzo, Caterina Bonfiglio, Gianluigi Giannelli and Giovanni De Pergola
Nutrients 2024, 16(18), 3094; https://doi.org/10.3390/nu16183094 - 13 Sep 2024
Viewed by 1201
Abstract
(1) Background: Metabolic dysfunction-associated liver disease (MASLD) is one of the most important causes of liver disease worldwide. Meat consumption is a growing trend and white meat has been shown to have beneficial effects on cardiometabolic risk factors. The aim of this study [...] Read more.
(1) Background: Metabolic dysfunction-associated liver disease (MASLD) is one of the most important causes of liver disease worldwide. Meat consumption is a growing trend and white meat has been shown to have beneficial effects on cardiometabolic risk factors. The aim of this study was to investigate the dose–response relationship between white meat intake and MASLD at survey level in a Southern Italy setting. (2) Methods: This cross-sectional study encompassed 1192 subjects (509 males, 42.7%) without missing data from the second wave of the NUTRIHEP cohort (2014–2016). Adjusted dose–response modeling was employed for statistical analysis; (3) Results: There were 587 subjects with MASLD (49.2%), i.e., 278 males (54.6%) and 309 females (45.2%). By increasing the intake, an unfavorable influence of white meat on MASLD was significantly revealed in females, whereas a protective effect of white meat was detectable in males. Male sex was shown to be involved in other associations in this study, such as influencing the preference for specific foods such as poultry and chicken skin. (4) Conclusions: Our data suggest that white meat does not have a clear-cut independent dose–response effect on MASLD, but sex may be a trigger moderator for age and BMI, with an increasing unfavorable effect of white meat in women, and a favorable effect in men. Full article
(This article belongs to the Special Issue Nutrition and Dietary Intake in Liver-Related Diseases)
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17 pages, 1558 KiB  
Article
Different Associations of Coffee Consumption with the Risk of Incident Metabolic Dysfunction-Associated Steatotic Liver Disease and Advanced Liver Fibrosis
by Jun-Hyuk Lee, JooYong Park and Sang Bong Ahn
Nutrients 2024, 16(1), 140; https://doi.org/10.3390/nu16010140 - 31 Dec 2023
Cited by 2 | Viewed by 2056
Abstract
Although coffee has a potential hepatoprotective effect, evidence of the relationship between coffee consumption and metabolic dysfunction-associated steatotic liver disease (MASLD) remains conflicting. There is limited evidence regarding the most appropriate coffee intake to prevent advanced liver fibrosis (ALF) in patients with MASLD. [...] Read more.
Although coffee has a potential hepatoprotective effect, evidence of the relationship between coffee consumption and metabolic dysfunction-associated steatotic liver disease (MASLD) remains conflicting. There is limited evidence regarding the most appropriate coffee intake to prevent advanced liver fibrosis (ALF) in patients with MASLD. We investigated the effect of coffee consumption on MASLD and ALF among 5266 participants without MASLD and 1326 with MASLD but without ALF. Participants were grouped by coffee intake: non-consumers, >0 and <1 cups/day, ≥1 and <2 cups/day, and ≥2 cups/day. Over a median follow-up of 11.6 years for MASLD and 15.7 years for ALF, coffee consumption did not significantly affect the incidence of MASLD, with 2298 new cases observed. However, a notable inverse association was found with ALF risk in patients with MASLD among those consuming coffee ≥2 cups/day (adjusted HR 0.57, 95% CI: 0.37–0.90, p = 0.014), especially among those consuming coffee ≥2 and <3 cups/day (adjusted HR 0.51, 95% CI: 0.30–0.89, p = 0.018). This suggests a potential hepatoprotective effect of coffee, especially in preventing the progression of liver fibrosis in patients with MASLD. These findings propose that coffee consumption could be a simple and effective approach to mitigate the risk of ALF in individuals with MASLD. Full article
(This article belongs to the Special Issue Nutrition and Dietary Intake in Liver-Related Diseases)
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