Special Issue "Early Nutrition and Re-programming of Health and Disease"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 31 December 2020.

Special Issue Editors

Prof. Dr. Cristina Campoy
Guest Editor
"Infant Nutrition and Metabolism Research Group" (PAI-CTS-187). EURISTIKOS Excellence Centre for Paediatric Research. Department of Paediatrics. School of Medicine. University of Granada. Spain
Interests: Early nutrition and metabolic programming; Neurodevelopment and brain structure and function; Gut microbiota and gut–brain axis; Obesity; Diabetes; Human milk and infant formulas; Metabolomics; Epigenetics
Special Issues and Collections in MDPI journals
Prof. Dr. Luis A. Moreno
Guest Editor
“Growth, Exercise, Nutrition and Development” (GENUD) Research Group, Facultad de Ciencias de la Salud, Universidad de Zaragoza, Zaragoza, Spain
Interests: pediatric nutrition; childhood obesity; body composition; nutritional status; nutritional epidemiology; lifestyle behaviors
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue of Nutrients is focused on the “Role of nutrition during early life on the re-programming of long-term health and disease”. The first 1000 days of life cover different critical periods for growth and development. During these critical days, the exposure to deficit or excess of several functional nutrients will impact the programming of organs and the development of metabolic systems. These exposures can alter the child’s health trajectory and impact the risk for impaired growth and cognition, neuropsychiatric illnesses, cardiometabolic or immune-system-associated diseases, and diminish the abilities of the offspring to contribute to society in later life. Recent human milk metabolomic, immunological, and microbiome approaches are increasing the knowledge about its composition, but also about its functional effects on the baby. Furthermore, human milk composition variability is determined by many genetic, metabolic, and environmental factors. As a gold standard, human milk is being considered the baseline for infant formula improvements; many new bioactive compounds present in human milk, such as milk fat globule membrane components, pre- and probiotics, human milk oligosaccharides, and osteopontin, are being intensively investigated to understand their role during early life. Complementary feeding also represents a window of opportunity to re-program some mis-programming consequences after several exposures during critical windows. Recent studies are leading to the establishment of growth and neurodevelopmental patterns associated to specific exposures. It is important to highlight that several pathological situations such as prematurity or low birth weight are already models of mal-programming, and need special attention regarding the development of an individualized nutrition. One of the most important challenges will be to define the best personalized nutrition for pregnant and lactating mothers, infants, and toddlers, aiming to achieve optimal growth, neurodevelopment, and brain functioning. Finally, special interest is developing regarding the gut–brain axis or the immune system development during early life in relation to the increase of allergic, inflammatory, and immune diseases all over the world. In this Special Issue, we aim to: 1) update the current knowledge and new data regarding origins of health and disease, aiming to design individual nutritional interventions; and 2) present novel approaches and data trying to optimize health trajectories and prevent non-communicable and neuropsychiatric disorders in later life and across generations.

Submissions may include original research, narrative reviews, and systematic reviews. We are interested in highlighting data from novel intervention studies that target key windows where nutrition has the greatest influence on future health (preconception, prenatal, and postnatal periods), explore how new functional components may re-program the risk of disease in specially vulnerable populations, and that update the approaches for individualized nutrition.

Prof. Cristina Campoy
Prof. Luis A. Moreno
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • early nutrition re-programming
  • human milk bioactive compounds
  • maternal and infant personalized nutrition
  • metabolomics in infant nutrition
  • infant gut microbiota
  • brain and immune system development

Published Papers (1 paper)

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Open AccessArticle
Early Nutrition eAcademy Southeast Asia e-Learning for Enhancing Knowledge on Nutrition during the First 1000 Days of Life
Nutrients 2020, 12(6), 1817; https://doi.org/10.3390/nu12061817 - 18 Jun 2020
Background: The double burden of both under- and overnutrition during the first 1000 days is highly prevalent in Southeast Asia (SEA), with major implications for lifelong health. Tackling this burden requires healthcare professionals (HCPs) to acquire evidence-based current knowledge and counselling skills. We [...] Read more.
Background: The double burden of both under- and overnutrition during the first 1000 days is highly prevalent in Southeast Asia (SEA), with major implications for lifelong health. Tackling this burden requires healthcare professionals (HCPs) to acquire evidence-based current knowledge and counselling skills. We assessed the needs of HCPs in SEA and developed a continuing medical education/professional development (CME/CPD) program using an e-learning platform to reduce existing gaps. Methods: European, Thai and Malaysian universities collaborated with SEA national nutrition associations in the Early Nutrition eAcademy Southeast Asia (ENeA SEA) project. We assessed HCPs’ needs using questionnaires and mapped CME/CPD programmes and regulations through stakeholder questionnaires. Using a co-creation approach, we established an e-learning platform. Evaluation in users was undertaken using questionnaires. Results: HCPs in SEA reported major training gaps relating to the first 1000 days of nutrition and limited impact of existing face-to-face training. Existing pre/postgraduate, residency and CME/CPD programmes did not adequately address the topic. To address these gaps, we produced a targeted e-learning platform with six modules and CME-tests. National ministries, Thai and Malaysian universities, and professional associations endorsed the training platform. To date, over 2600 HCPs have registered. Evaluation shows high acceptance and a very positive assessment. Conclusions: Dedicated e-learning can reduce major gaps in HCP training in SEA regarding nutrition during the first 1000 days of life at scale and is highly valued by both users and key stakeholders. Full article
(This article belongs to the Special Issue Early Nutrition and Re-programming of Health and Disease)
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