Next Article in Journal
Efficacy of Ingesting an Oral Rehydration Solution after Exercise on Fluid Balance and Endurance Performance
Next Article in Special Issue
Long-Chain Polyunsaturated Fatty Acids (LCPUFAs) and the Developing Immune System: A Narrative Review
Previous Article in Journal
Prototype Gluten-Free Breads from Processed Durum Wheat: Use of Monovarietal Flours and Implications for Gluten Detoxification Strategies
Previous Article in Special Issue
Bifidobacterium longum subsp. infantis CECT7210 (B. infantis IM-1®) Displays In Vitro Activity against Some Intestinal Pathogens
Open AccessArticle

The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study

1
Department of Paediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, Spain
2
EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, University of Granada, 18016 Granada, Spain
3
Instituto de Investigación Biosanitaria ibs. GRANADA, Health Sciences Technological Park, 18012 Granada, Spain
4
Mind, Brain and Behaviour Research Centre-CIMCYC, University of Granada, 18011 Granada, Spain
5
Nutrition and Biochemistry Department, Faculty of Sciences, Pontificia Universidad Javeriana, 110231 Bogotá, Colombia
6
Department of Personality, Evaluation and Psychological Treatment, School of Psychology, University of Granada, 18011 Granada, Spain
7
Ordesa Laboratories, S.L., 08820 Barcelona, Spain
8
Department of Biostatistics, School of Medicine, University of Granada, 18016 Granada, Spain
9
Spanish Network of Biomedical Research in Epidemiology and Public Health (CIBERESP), Granada’s Node, Institute of Health Carlos III, 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3825; https://doi.org/10.3390/nu12123825
Received: 29 October 2020 / Revised: 10 December 2020 / Accepted: 14 December 2020 / Published: 15 December 2020
(This article belongs to the Special Issue Early Nutrition and Re-programming of Health and Disease)
Although early life nutrition influences brain development and mental health, the long-term effects of supplemented infant formula on children´s behavior remain unclear. We analyzed the effects of a bioactive nutrients-enriched-infant formula on children’s behavior up to 2.5 years, compared to a standard infant formula or breastfeeding. Current analysis involved 70 children who were fed a standard infant formula (SF, n = 29) or a bioactive compounds enriched-infant formula (EF, n = 41), during their first 18 months of life, and 33 breastfed (BF) children (reference group) participating in the COGNIS study. Behavioral problems were evaluated using the Child Behavior Checklist at 18 months and 2.5 years. Different statistical analyses were performed using SPSS. EF children aged 2.5 years presented fewer pathological affective problems than SF children. Besides, SF children were classified more frequently as bordering on internalizing problems than BF children. Rates of externalizing problems were increased in SF infants compared to EF and BF infants. Higher maternal IQ was found to have beneficial effects on internalizing and total problem rate in their offspring at 18 months of life; finally, higher maternal educational level was related with fewer ADHD problems in children at 18 months, as well as internalizing, externalizing, total and anxiety problems in children aged 2.5 years. Our analysis suggests that enriched infant formula fed infants seem to show fewer behavioral problems up to 2.5 years compared to a standard infant formula-fed infants. In addition to type of early feeding, maternal IQ and educational level seem to play a key role on children behavioral development. View Full-Text
Keywords: infant formula; milk fat globule membrane; long-chain polyunsaturated fatty acids; bioactive compounds; children behavior; breastfeeding infant formula; milk fat globule membrane; long-chain polyunsaturated fatty acids; bioactive compounds; children behavior; breastfeeding
Show Figures

Figure 1

MDPI and ACS Style

Nieto-Ruiz, A.; Diéguez, E.; Sepúlveda-Valbuena, N.; Herrmann, F.; Cerdó, T.; López-Torrecillas, F.; De-Castellar, R.; Jiménez, J.; Pérez-García, M.; Miranda, M.T.; Catena, A.; García-Santos, J.A.; Bermúdez, M.G.; Campoy, C. The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study. Nutrients 2020, 12, 3825. https://doi.org/10.3390/nu12123825

AMA Style

Nieto-Ruiz A, Diéguez E, Sepúlveda-Valbuena N, Herrmann F, Cerdó T, López-Torrecillas F, De-Castellar R, Jiménez J, Pérez-García M, Miranda MT, Catena A, García-Santos JA, Bermúdez MG, Campoy C. The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study. Nutrients. 2020; 12(12):3825. https://doi.org/10.3390/nu12123825

Chicago/Turabian Style

Nieto-Ruiz, Ana; Diéguez, Estefanía; Sepúlveda-Valbuena, Natalia; Herrmann, Florian; Cerdó, Tomás; López-Torrecillas, Francisca; De-Castellar, Roser; Jiménez, Jesús; Pérez-García, Miguel; Miranda, María T.; Catena, Andrés; García-Santos, José A.; Bermúdez, Mercedes G.; Campoy, Cristina. 2020. "The Effects of an Infant Formula Enriched with Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids and Synbiotics on Child Behavior up to 2.5 Years Old: The COGNIS Study" Nutrients 12, no. 12: 3825. https://doi.org/10.3390/nu12123825

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop