nutrients-logo

Journal Browser

Journal Browser

Featured Papers on Dietary Lipids and Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Lipids".

Deadline for manuscript submissions: closed (20 February 2024) | Viewed by 2338

Special Issue Editors


E-Mail Website
Guest Editor
UETeM-Molecular Pathology Group, Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, IDIS-CIMUS, University of Santiago de Compostela, 15703 Santiago de Compostela, Spain
Interests: infrequent lipodystrophies; adipose tissue; laminopathies; seipinopathies; neurodegeneration; diabetes mellitus; transgenic mice; insulin resistance
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Division of Endocrinology and Nutrition, University Hospital of Santiago de Compostela, Molecular Endocrinology Group-IDIS, Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, 15706 Santiago de Compostela-A Coruña, Spain
2. CIBER Pathophysiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, 28668 Madrid, Spain
Interests: metabolic syndrome; dietetics; clinical nutrition; nutrition support; inborn error of metabolism; lipid metabolism

Special Issue Information

Dear Colleagues,

We invite you to contribute to a Special Issue of Nutrients, entitled “Featured Papers on Dietary Lipids and Human Health”.

In a balanced diet, dietary fats should be 20-35% of the total energy intake, providing lipids with structural, energetic and many other important functions, which allow humans to maintain adequate body composition and homeostasis. Cardiovascular, nervous, immunological, skin, bone and blood-clotting systems, among others, are influenced by the presence of different types of dietary lipids.

It should be noted that in addition to the amount of dietary fat, its quality is essential to maintain an adequate state of health or, on the contrary, can contribute to the development of diseases, especially chronic metabolic and cardiovascular diseases. Additionally, the interaction of dietary lipids with other nutrients, lifestyles, and genetic and epigenetic factors may be relevant to the effects on health status.

Dietary intervention along with other factors may contribute to changes in the associated risks.

This Special Issue of Nutrients welcomes the submission of manuscripts (focused on clinical or experimental studies) describing either original research or reviews of the scientific literature related to the influence of dietary lipids on health and disease.

Dr. David Araújo-Vilar
Prof. Dr. Miguel Angel Martinez Olmos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dietary lipids
  • saturated fatty acids
  • monounsaturated fatty acids
  • omega-3 polyunsaturated fatty acids
  • omega-6 polyunsaturated fatty acids
  • non-communicable chronic diseases

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

22 pages, 3915 KiB  
Article
Comparison of the Effects of Monounsaturated Fatty Acids and Polyunsaturated Fatty Acids on Liver Lipid Disorders in Obese Mice
by Wen Liu, Min Zhu, Meng Gong, Wen Zheng, Xin Zeng, Qing Zheng, Xiaoyu Li, Fudong Fu, Yingyi Chen, Jingqiu Cheng, Zhiyong Rao, Yanrong Lu and Younan Chen
Nutrients 2023, 15(14), 3200; https://doi.org/10.3390/nu15143200 - 19 Jul 2023
Cited by 5 | Viewed by 2027
Abstract
Obesity is a recognized epidemic worldwide, and the accumulation of excess free saturated fatty acids (SFAs) in cells induces cellular lipotoxic damage and increases the risk of a wide spectrum of metabolic diseases including type 2 diabetes (T2D) and nonalcoholic fatty liver disease [...] Read more.
Obesity is a recognized epidemic worldwide, and the accumulation of excess free saturated fatty acids (SFAs) in cells induces cellular lipotoxic damage and increases the risk of a wide spectrum of metabolic diseases including type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD). Monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs) have been reported to combat SFA-induced cellular damage. However, the comparative studies of the two types of unsaturated fatty acids (UFAs) are still limited. We investigated the effects of different MUFAs and PUFAs in the human hepatocyte line L-02 cells in vitro, and in high-fat-diet (HFD)-induced obese C57BL/6 mice in vivo. The results of the in vitro study showed that SFAs induced significant cellular lipotoxic damage, but the combination of MUFAs/PUFAs with SFAs significantly improved the impaired cell viability. Particularly, oleic acid (OA) was superior to eicosapentaenoic acid (EPA), Docosahexaenoic acid (DHA), and arachidonic acid (AA) in terms of its anti-apoptotic effect and inhibition of endoplasmic reticulum (ER) stress. In vivo, both olive-oil-enriched (HFD + OO) and fish-oil-enriched high-fat diets (HFD + FO) reduced hepatic steatosis and improved insulin sensitivity in obese mice. However, FO induced an abnormal increase in serum aspartate aminotransferase (AST) and an increase in the oxidative stress indicator Malondialdehyde (MDA). Liver-targeted lipidomic analysis showed that liver lipid metabolites under the two types of UFA dietary interventions differed from the HFD group, modulating the abundance of some lipid metabolites such as triglycerides (TGs) and glycerophospholipids. Furthermore, the FO diet significantly increased the abundance of the associated FA 20:5 long-chain lipid metabolites, whereas the OO diet regulated the unsaturation of all fatty acids in general and increased the abundance of FA 18:1 in the overall lipid metabolites, especially TGs, which may primarily contribute to the FO, and OO drove protection in NAFLD. Full article
(This article belongs to the Special Issue Featured Papers on Dietary Lipids and Human Health)
Show Figures

Figure 1

Back to TopTop