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Nutrients
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Dietary and Nutritional Therapies to Improve Digestive Disorders
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Dietary and Nutritional Therapies to Improve Digestive Disorders

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 25 August 2025 | Viewed by 3770

Special Issue Editors

Prof. Dr. Jorge Fonseca

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Guest Editor
1. Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, Monte de Caparica, 2829-511 Almada, Portugal
2. Artificial Feeding Team (GENE), Gastroenterology Department, Hospital Garcia de Orta, Almada, Portugal
Interests: clinical nutrition and artificial nutrition; digestive disorders; the systemic impact of digestive disorders; nutritional assessment (methods, techniques, and tools)
Special Issues, Collections and Topics in MDPI journals
Dr. Luísa Glória

E-Mail Website
Guest Editor
Gastroenterology Department, Hospital Beatriz Angelo, 2674-514 Loures, Portugal
Interests: clinical nutrition; clinical gastroenterology; digestive oncology; inflammatory bowel diseases
Dr. Maria Leonor Silva

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Guest Editor Assistant
Applied Nutrition Research Group (GENA), Nutrition Lab, Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, Monte de Caparica, 2829-511 Almada, Portugal
Interests: clinical nutrition; dietary strategies for metabolic diseases; nutrition in rheumatic disease; metabolism of plant bioactive compounds and health benefits; oxidative stress; diabetes mellitus

Special Issue Information

Dear Colleagues,

Digestive disorders generate anorexia and intake restrictions, prolonged fasting periods, malabsorption, and chronic inflammation that releases stress mediators with catabolic activity. They often lead to malnutrition with a major impact on clinical outcomes. The treatment of digestive disorders must consider the need for dietary intervention, directly targeting the pathophysiological mechanisms of the disease or preventing and treating disease-associated malnutrition. In managing digestive disorders, doctors and other health professionals must consider dietary and nutritional intervention at several levels.

Lactose intolerance or avoidance diet is used in eosinophilic esophagitis as a basic disease treatment, such as celiac disease.

It is an adjuvant that reduces symptoms and improves quality of life, as in GERD or IBS.

The prevention and treatment of disease-associated malnutrition, with an important outcome impact, is mandatory in chronic liver or pancreatic disease, IBD, or digestive cancer.

In this Special Issue, we focus on the different dietary and nutritional intervention opportunities in digestive disorders. As clinicians and researchers, you can share your expertise and studies with the readers of this Special Issue. Submissions can include original articles on intervention and epidemiological studies as well as review articles.

We are waiting for your contributions.

Prof. Dr. Jorge Fonseca
Dr. Luísa Glória
Guest Editors

Dr. Maria Leonor Silva
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • digestive diseases
  • malabsorption
  • malnutrition
  • nutritional intervention
  • diet therapy

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Published Papers (3 papers)

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Research

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11 pages, 463 KiB  
Article
Home Parenteral Support in Chronic Intestinal Failure—First Results from a Pioneer Portuguese Intestinal Failure Center
by Ivo Mendes, Francisco Vara-Luiz, Carolina Palma, Gonçalo Nunes, Maria João Lima, Cátia Oliveira, Marta Brito, Ana Paula Santos, Carla Adriana Santos and Jorge Fonseca
Nutrients 2024, 16(22), 3880; https://doi.org/10.3390/nu16223880 - 14 Nov 2024
Viewed by 1029
Abstract
Background/Objectives: Home parenteral support (HPS) is the core of chronic intestinal failure (IF) treatment. For legal reasons, HPS in Portugal lags behind other European countries, and only a few patients were taken care of at home by nurses. Now, the legislation has changed, [...] Read more.
Background/Objectives: Home parenteral support (HPS) is the core of chronic intestinal failure (IF) treatment. For legal reasons, HPS in Portugal lags behind other European countries, and only a few patients were taken care of at home by nurses. Now, the legislation has changed, allowing patient self-care. The authors report their pioneer experience as the largest Portuguese IF center, evaluating the underlying conditions leading to IF, HPS nutritional impact, HPS-related complications and survival. Methods: This is a retrospective study including IF patients who underwent HPS in a Portuguese IF center. The data included demographics, underlying conditions, IF types, HPS duration, BMI at the beginning and end of HPS/follow-up, complications, microbiological agents of infectious complications and current status (deceased or alive with/without HPS). Survival was calculated until death or September 2024. Results: A total of 23 patients (52.2% female, mean age 57.3 years), all with type III IF, were included. Short bowel syndrome (SBS) was the most common cause of IF (69.6%). Of the included patients, 78.3% received home parenteral nutrition; the others received home parenteral hydration. The mean BMI increased significantly, from 19.1 kg/m2 to 22.5 kg/m2 (p < 0.001). Two patients received Teduglutide. The most common complication was catheter-related bloodstream infection (2.5/1000 catheter days). The complications did not increase with patient self-care. At the end of follow-up, 21.7% of patients remained on HPS, 34.8% were alive without HPS, and 43.5% died. The average survival was 43.4 months. One death (4.35%) was attributable to HPS-related complications. Conclusions: The conditions underlying IF varied, with SBS being the most frequent condition. HPS improved the BMI, allowing considerable survival. Despite the complications and one attributable death, HPS was safe, even when relying on patient self-care. Full article
(This article belongs to the Special Issue Dietary and Nutritional Therapies to Improve Digestive Disorders)
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Review

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32 pages, 1583 KiB  
Review
Nutraceuticals for Gut–Brain Axis Health: A Novel Approach to Combat Malnutrition and Future Personalised Nutraceutical Interventions
by Litai Liu, Wen Qi, Na Zhang, Jinhao Zhang, Shen Liu, Huan Wang, Lianzhou Jiang and Ying Sun
Nutrients 2025, 17(9), 1551; https://doi.org/10.3390/nu17091551 (registering DOI) - 30 Apr 2025
Abstract
The gut–brain axis (GBA) is a bidirectional communication network between the gastrointestinal tract and the brain, modulated by gut microbiota and related biomarkers. Malnutrition disrupts GBA homeostasis, exacerbating GBA dysfunction through gut dysbiosis, impaired neuroactive metabolite production, and systemic inflammation. Nutraceuticals, including probiotics, [...] Read more.
The gut–brain axis (GBA) is a bidirectional communication network between the gastrointestinal tract and the brain, modulated by gut microbiota and related biomarkers. Malnutrition disrupts GBA homeostasis, exacerbating GBA dysfunction through gut dysbiosis, impaired neuroactive metabolite production, and systemic inflammation. Nutraceuticals, including probiotics, prebiotics, synbiotics, postbiotics, and paraprobiotics, offer a promising approach to improving GBA homeostasis by modulating the gut microbiota composition and related neuroactive metabolites. This review aims to elucidate the interplay between gut microbiota-derived biomarkers and GBA dysfunction in malnutrition and evaluate the potential of nutraceuticals in combating malnutrition. Furthermore, it explores the future of personalised nutraceutical interventions tailored to individual genetic and microbiome profiles, providing a targeted approach to optimise health outcomes. The integration of nutraceuticals into GBA health management could transform malnutrition treatment and improve cognitive and metabolic health. Full article
(This article belongs to the Special Issue Dietary and Nutritional Therapies to Improve Digestive Disorders)
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17 pages, 295 KiB  
Review
Adjunct Therapies to Standard Care for IBS and IBD Patients: Digestive Symptoms Improvement and Quality of Life Optimization
by Veronique Traynard
Nutrients 2024, 16(22), 3927; https://doi.org/10.3390/nu16223927 - 18 Nov 2024
Viewed by 2339
Abstract
Background: The prevalence of both inflammatory bowel diseases (IBD) and Irritable Bowel Syndrome (IBS) is increasing, with persistent digestive symptoms, an altered quality of life, and higher rates of anxiety, chronic fatigue, and sleep trouble than the general population. Methods: This scoping review [...] Read more.
Background: The prevalence of both inflammatory bowel diseases (IBD) and Irritable Bowel Syndrome (IBS) is increasing, with persistent digestive symptoms, an altered quality of life, and higher rates of anxiety, chronic fatigue, and sleep trouble than the general population. Methods: This scoping review will analyze the latest clinical practice recommendations and clinical studies on non-pharmaceutical interventions such as diet adaptations, physical activity, cognitive behavioral therapies, and medical nutrition therapies such as probiotics, soluble fibers, chitin-glucan, and micronutrients for digestive symptoms relief, quality of life improvement and nutritional deficiencies correction in IBS and IBD patients. The objective is to help healthcare practitioners and dietitians to build personalized care program for IBD and IBS patients. Results: Mediterranean diet, physical activity, cognitive behavioral therapies and medical nutrition therapies such as selected probiotics, soluble fibers, chitin glucan, peppermint oil and micronutrients are effective as adjunct therapies. Conclusions: These adjunct therapies may help to reduce persistent digestive symptoms, correct nutritional deficiencies and improve quality of life of IBS and IBD patients. Full article
(This article belongs to the Special Issue Dietary and Nutritional Therapies to Improve Digestive Disorders)
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