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Clinical Nutrition in Kidney Disease

A topical collection in Nutrients (ISSN 2072-6643). This collection belongs to the section "Clinical Nutrition".

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Editor


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Collection Editor
1. Chronic Kidney Insufficiency Research Group, Italian Society of Nephrology, Rome, Italy
2. Kidney Stones Pathologies Research Group, Italian Society of Nephrology, Rome, Italy
Interests: renal disease; dialysis; hemodialysis; chronic renal failure; renal; chronic kidney failure; clinical nephrology; kidney; randomized control trials; renal failure; prevention and diagnosis of kidney stones pathologies; renal nutrition
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Topical Collection Information

Dear Colleagues,

As we all know, standardizing the prevention and treatment of kidney diseases it is no longer sustainable. Today, the diagnosis and treatment of kidney diseases must be conducted using precision medicine that is tailored to the patient. This Topical Collection aims to encourage the presentation of works on the latest nutritional strategies for patients at all stages of chronic renal failure, while also taking physiological renal aging into account. Furthermore, diffusion must be encouraged when prescribing a personalized nutritional plan alongside incremental dialysis strategies. Finally, it is necessary to apply a precise nutritional approach for former patients with recurrent kidney stones.

This Topical Collection encourages authors to submit original research articles or reviews addressing these areas.

Dr. Piergiorgio Bolasco
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • dialysis
  • chronic renal failure
  • renal nutrition
  • nephrolithiasis

Published Papers (3 papers)

2025

Jump to: 2024

11 pages, 364 KiB  
Review
Incremental Hemodialysis: Review of Clinical Trials Focused on Patients Undergoing Once-Weekly Hemodialysis
by Piergiorgio Bolasco
Nutrients 2025, 17(4), 713; https://doi.org/10.3390/nu17040713 - 17 Feb 2025
Viewed by 759
Abstract
Background/objectives: The implementation of appropriate hemodialysis treatment in the transition from end-stage kidney disease to reduced frequency schedules represents a major challenge. The aim of our work is to report only treatment protocols that used once-weekly hemodialysis. Methods: The benefits and [...] Read more.
Background/objectives: The implementation of appropriate hemodialysis treatment in the transition from end-stage kidney disease to reduced frequency schedules represents a major challenge. The aim of our work is to report only treatment protocols that used once-weekly hemodialysis. Methods: The benefits and risks of 1WHD were explored in this systematic review. A search of MEDLINE, Scopus, and the Cochrane Central Register was conducted to identify publications relating to once-weekly hemodialysis trials performed between June 1981 and December 2024 and assess clinical impact, duration, safety, and mortality. Items, including age, causes of chronic kidney disease (CKD), creatinine levels, Blood Urea Nitrogen and GFR values, diuresis, nutritional supplementation, drop-out, survival, clinical benefit or drawbacks, and data from eventual control groups relating to higher frequency weekly HD sessions were included. Outcome at the end of a 1WHD regimen was represented by death or transition to twice/thrice-weekly HD rhythms. Results: A total of 1238 articles focused on IHD were included in the review, and 1226 trials were excluded as they referred either to twice-weekly hemodialysis (2WHD) schedules or failed to meet eligibility criteria, whilst another two were excluded based on incomplete outcome or patient recruitment issues. A total of eight articles comprising 254 patients undergoing 1WHD schedules were ultimately identified and evaluated. Only three studies focused on a comparison with a 1WHD schedule, whilst 107 referred to thrice-weekly HD (3WHD) and 15 2WHD). This choice demonstrated the possibility of slowing down the progression of CKD in the patients studied. Daily amino acid supplementation also proved to be beneficial. However, the milestone on which the 1WHD protocol is based is a low-protein diet. Conclusions: 1WHD has been shown to be safe and may result in improved clinical outcomes, particularly in appropriately selected patients. Large-scale randomized controlled trials should be carried out to confirm these potential advantages. However, the standard recruitment techniques applied tended to prevent suitably selected patients from transitioning into less frequent and potentially long-lasting 1WHD schedules. Full article
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21 pages, 1434 KiB  
Review
Chrononutrition in Chronic Kidney Disease
by Pilar C. Castro-Mata, Alfonso M. Cueto-Manzano, Barbara Vizmanos, Ailema González-Ortiz, Alejandra Betancourt-Núñez and Fabiola Martín-del-Campo
Nutrients 2025, 17(3), 389; https://doi.org/10.3390/nu17030389 - 22 Jan 2025
Viewed by 1640
Abstract
Chrononutrition, the study of the interaction between biological rhythms and nutrition, has emerged as a promising field for addressing metabolic health. However, its role in chronic kidney disease (CKD) remains underexplored. CKD patients often experience circadian disruptions due to renal, metabolic, treatment-related, and [...] Read more.
Chrononutrition, the study of the interaction between biological rhythms and nutrition, has emerged as a promising field for addressing metabolic health. However, its role in chronic kidney disease (CKD) remains underexplored. CKD patients often experience circadian disruptions due to renal, metabolic, treatment-related, and lifestyle factors, which may influence their nutritional status and clinical outcomes. Objective: to synthesize and analyze the existing evidence on chrononutrition in CKD patients, identify knowledge gaps, and propose directions for future research across different stages of CKD. Initially, this review contextualizes circadian physiology, alignment, and chronodisruption to explore such factors in CKD patients, focusing on chrononutrition variables already studied in the general population. We discuss how dietary timing and habit adjustments could influence CKD clinical outcomes, offering insights into circadian impacts on disease management. This new approach could optimize patient care, encouraging further research, particularly in the development of personalized strategies for different stages of the disease. Full article
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2024

Jump to: 2025

10 pages, 2614 KiB  
Article
Association between Dietary Acid Load and Chronic Kidney Disease in the Chinese Population: A Comprehensive Analysis of the China Health and Nutrition Survey (2009)
by Shurui Wang, Xiaohong Fan, Xixi Zheng, Peng Xia, Haiou Zou, Zhaofeng Zhang and Limeng Chen
Nutrients 2024, 16(15), 2461; https://doi.org/10.3390/nu16152461 - 29 Jul 2024
Cited by 1 | Viewed by 1841
Abstract
Background: Dietary acid load (DAL) is closely related to several chronic diseases. However, the link between DAL and chronic kidney disease (CKD) remains scarce and without data from the Chinese populations whose diet is quite different from people in Western countries. Methods: This [...] Read more.
Background: Dietary acid load (DAL) is closely related to several chronic diseases. However, the link between DAL and chronic kidney disease (CKD) remains scarce and without data from the Chinese populations whose diet is quite different from people in Western countries. Methods: This study evaluated DAL by potential renal acid load (PRAL) and net endogenous acid production (NEAP). We clarified the relationship between DAL and CKD by logistic regression analysis based on data from the China Health and Nutrition Survey (CHNS). Results: The final analysis included 7699 individuals, of whom 811 (11.44%) were CKD patients. Although there was no notable link between PRAL and CKD, higher NEAP levels were independently correlated with CKD. As NEAP values rise, so does CKD prevalence. This trend remains highly significant even after adjustments. In subgroup analyses, the relationship between NEAP and CKD was more consistent in the elderly and subjects with a waistline of less than 82 cm and those without diabetes and heart disease. RCS analysis further confirmed the clear linear relationship between the OR of CKD and NEAP score. Conclusions: This study highlighted that higher NEAP was positively correlated with the risk of CKD. Full article
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