Therapeutics for Iron-Related Disorders: Current Approaches and Nutritional Perspectives
A Special Issue of Nutrients (ISSN 2072-6643) belonging to the section "Micronutrients and Human Health".
Deadline for manuscript submissions: 30 December 2026 | Viewed by 1391
Editor
Interests: mammalian iron metabolism and related disorders; oxygen signaling; colorectal cancer; host–microbiota crosstalk; host micronutrient sensing
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Iron is essential for almost all living organisms. Dietary iron is the only source of iron for mammals, and iron levels must be tightly maintained as imbalance can lead to adverse health outcomes. In humans, iron deficiency and overload disorders are globally prevalent in distinct geographical regions. Iron deficiency is the most common nutritional disorder. About 60% of the total global burden of anemia is represented by iron deficiency anemia (IDA), mainly affecting developing nations. In contrast, iron overload disorders are genetically encoded and are more prevalent (1 in 300 to 500 individuals) in the Western population. Dysregulation of intestinal iron absorption is the hallmark of both deficiency and overload disorders. Currently, our targets for iron-related disorders revolve around the following strategies: (1) Oral or parenteral delivery of iron for anemia. (2) Restriction/removal of iron via chelation or phlebotomy for iron overload. (3) More recently, targeting the hepcidin–Fpn1 axis and hypoxia inducible factor (HIF) pathways for managing both ends of the spectrum. However, strategies for iron-related disorder management are still lacking, and newer approaches specifically targeting aspects of cellular iron flux are warranted. This Special Issue shall focus on the ongoing and upcoming nutritional approaches towards novel therapeutic management of iron-related disorders.
Dr. Nupur Das
Guest Editor
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Keywords
- intestinal iron absorption
- intestinal HIF regulation
- ferritinophagy
- nutritional aspect of iron homeostasis
- hereditary disorders of iron absorption
- gut microbiota
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