Personal Dietary and Lifestyle Interventions in MASLD: Clinical and Experimental Perspectives
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".
Deadline for manuscript submissions: 25 August 2025 | Viewed by 437
Special Issue Editor
Interests: metabolic syndrome; insulin resistance; chronic hepatitis C; liver; antioxidants; mesenchymal stem cell; inflammatory biomarkers; liver diseases; fatty liver; diabetes; hepatitis; cirrhosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), is the result of a complex interplay of genetic and environmental factors. Beyond genetics, nutrition, and physical activity are key determinants of MASLD onset and progression. The role of diet and lifestyle is crucial in both preventing and treating MASLD.
A diet rich in vegetables, fruits, whole grains, and oily fish can help in maintaining a healthy weight and reducing the risk of developing MASLD. In parallel, limiting one’s intake of saturated fats, refined carbohydrates, and added sugars is essential. Among plant-based dietary patterns, the Mediterranean diet has shown efficacy in reducing liver fat accumulation.
In treating MASLD, lifestyle interventions should focus on weight loss. A calorie-restricted diet, typically aiming for a 7-10% weight reduction, can significantly reduce liver steatosis, inflammation, and fibrosis. Beyond weight loss, promoting a higher intake of polyphenol-rich foods is recommended, as this may counteract liver damage.
Overall, a personalized nutritional approach, in conjunction with increased physical activity, forms the cornerstone of MASLD management, potentially halting or even reversing disease progression.
For this Special Issue, we will accept clinical studies reporting on the preventative and therapeutic effects of dietary patterns and specific nutrients in MASLD. Studies in experimental models of MASLD are also welcome.
Dr. Federico Salomone
Guest Editor
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Keywords
- MASLD
- lifestyle
- healthy diet
- dietary patterns
- nutrition
- physical activity
- polyphenols
- weight reduction
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